11,192 results
Search Results
2. The impact of nutrition on the lives of patients with digestive cancers: a position paper
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Vitaloni, Marianna, Caccialanza, Riccardo, Ravasco, Paula, Carrato, Alfredo, Kapala, Aleksandra, de van der Schueren, Marian, Constantinides, Dora, Backman, Eva, Chuter, David, Santangelo, Claudia, and Maravic, Zorana
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- 2022
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3. Letter to the editor regarding the paper by A. Boileve et al.: Safety of direct oral anticoagulants in patients with advanced solid tumors receiving anti‑VEGF agents: a retrospective study.
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Inouri, Tinhinane, Noel, Johanna, Blanchet, Benoît, and Thomas-Schoemann, Audrey
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Concomitant direct oral anticoagulants (DOACs) and tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor (anti-VEGF TKI) have been associated with a higher risk of bleeding. Nevertheless, concomitant administration seems frequent in clinical practice in patients with cancer-associated thrombosis and appears to be safe according to the retrospective study by Boileve A. et al. But the risk of an additional pharmacokinetic interaction between anti-VEGF TKI and DOACs must be considered, in case of P-glycoprotein (P-gp) inhibition by the TKI. We describe a case report with a major bleeding event in a renal metastatic cancer patient treated with cabozantinib and rivaroxaban. This case highlights the difficult therapeutic decision in a complex patient with cancer-associated thrombosis, who refused the anticoagulant subcutaneous route. Accumulation of bleeding risk factors (genito-urinary tumor localization) was additive to several pharmacodynamic interactions (acetylsalicylic acid, venlafaxine) and a potential pharmacokinetic interaction between cabozantinib and rivaroxaban. Indeed, cabozantinib-related P-glycoprotein inhibition could have led to a supratherapeutic level of rivaroxaban, contributing partly to the bleeding event. Before combining an anti-VEGF TKI and DOACs, a multidisciplinary pretherapeutic assessment seems crucial to evaluate the patient’s bleeding risk factors, pharmacodynamic interactions, and the risk of pharmacokinetic interactions mediated by P-gp. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Emerging challenges in the evaluation of fever in cancer patients at risk of febrile neutropenia in the era of COVID-19: a MASCC position paper
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Cooksley, Tim, Font, Carme, Scotte, Florian, Escalante, Carmen, Johnson, Leslie, Anderson, Ronald, and Rapoport, Bernardo
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- 2021
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5. Considerations for establishing and maintaining international research collaboration: the example of chemotherapy-induced peripheral neurotoxicity (CIPN)—a white paper.
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Alberti, Paola, Argyriou, Andreas A., Bruna, Jordi, Damaj, M. Imad, Faithfull, Sara, Harding, Alice, Hoke, Ahmet, Knoerl, Robert, Kolb, Noah, Li, Tiffany, Park, Susanna B., Nathan, P., Tamburin, Stefano, Thomas, Simone, and Smith, Ellen Lavoie
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Purpose: This white paper provides guidance regarding the process for establishing and maintaining international collaborations to conduct oncology/neurology-focused chemotherapy-induced peripheral neurotoxicity (CIPN) research. Methods: An international multidisciplinary group of CIPN scientists, clinicians, research administrators, and legal experts have pooled their collective knowledge regarding recommendations for establishing and maintaining international collaboration to foster advancement of CIPN science. Results: Experts provide recommendations in 10 categories: (1) preclinical and (2) clinical research collaboration; (3) collaborators and consortiums; (4) communication; (5) funding; (6) international regulatory standards; (7) staff training; (8) data management, quality control, and data sharing; (9) dissemination across disciplines and countries; and (10) additional recommendations about feasibility, policy, and mentorship. Conclusion: Recommendations to establish and maintain international CIPN research collaboration will promote the inclusion of more diverse research participants, increasing consideration of cultural and genetic factors that are essential to inform innovative precision medicine interventions and propel scientific discovery to benefit cancer survivors worldwide. Relevance to inform research policy: Our suggested guidelines for establishing and maintaining international collaborations to conduct oncology/neurology-focused chemotherapy-induced peripheral neurotoxicity (CIPN) research set forth a challenge to multinational science, clinical, and policy leaders to (1) develop simple, streamlined research designs; (2) address logistical barriers; (3) simplify and standardize regulatory requirements across countries; (4) increase funding to support international collaboration; and (5) foster faculty mentorship. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Nursing role in the assessment and care of hepatic sinusoidal obstruction syndrome patients: a consensus paper by the “Gruppo Italiano Trapianto di Midollo Osseo”
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Botti, Stefano, Agreiter, Iris, Orlando, Laura, Gargiulo, Gianpaolo, Bonifazi, Francesca, Banfi, Marina Marialuisa, Cappucciati, Lorella, Caffarri, Cristiana, De Cecco, Valentina, Deiana, Giuseppe Marco, Gavezzotti, Marta, Magarò, Antonio, Netti, Maria Giovanna, Pignatelli, Adriana Concetta, Rostagno, Elena, Samarani, Emanuela, Cardoso, Janini Silva, Soave, Sonia, Valente, Concetta Maria, Vedovetto, Alessio, Zecca, Marco, Luminari, Stefano, Merli, Francesco, and Guberti, Monica
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- 2020
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7. Electronic versus paper-pencil methods for assessing chemotherapy-induced peripheral neuropathy
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Knoerl, Robert, Gray, Evan, Stricker, Carrie, Mitchell, Sandra A., Kippe, Kelsey, Smith, Gloria, Dudley, William N., and Lavoie Smith, Ellen M.
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- 2017
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8. Guidance for establishing an integrative oncology service in the Australian healthcare setting—a discussion paper
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Grant, Suzanne J., Hunter, Jennifer, Bensoussan, Alan, and Delaney, Geoff P.
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- 2017
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9. Evaluation of quality of life using a tablet PC-based survey in cancer patients treated with radiotherapy: a multi-institutional prospective randomized crossover comparison of paper and tablet PC-based questionnaires (KROG 12–01)
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Kim, Haeyoung, Park, Hee Chul, Yoon, Sang Min, Kim, Tae Hyun, Kim, Jinsung, Kang, Min Kyu, Jung, Jinhong, Kim, Sang-Won, Yea, Ji Woon, Park, Sung Ho, and Park, Young Suk
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- 2016
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10. Can a computerized format replace a paper form in PRO and HRQL evaluation? Psychometric testing of the computer-assisted LCSS instrument (eLCSS-QL)
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Hollen, Patricia J., Gralla, Richard J., Stewart, John A., Meharchand, Jacinta M., Wierzbicki, Rafal, and Leighl, Natasha
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- 2013
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11. SINPE Position Paper on the use of home parenteral nutrition in cancer patients.
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Bozzetti, Federico, Caccialanza, Riccardo, Cotogni, Paolo, Finocchiaro, Concetta, Pironi, Loris, Santarpia, Lidia, and Zanetti, Michela
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SHORT bowel syndrome , *PARENTERAL feeding , *CANCER patients , *ENTERAL feeding , *CENTRAL line-associated bloodstream infections , *CENTRAL venous catheters - Published
- 2022
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12. Examining guidelines and new evidence in oncology nutrition: a position paper on gaps and opportunities in multimodal approaches to improve patient care.
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Prado, Carla M., Laviano, Alessandro, Gillis, Chelsia, Sung, Anthony D., Gardner, Maureen, Yalcin, Suayib, Dixon, Suzanne, Newman, Shila M., Bastasch, Michael D., Sauer, Abby C., Hegazi, Refaat, and Chasen, Martin R.
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ONCOLOGY nursing , *MEDICAL personnel , *MUSCLE mass , *NUTRITIONAL status , *NUTRITION , *PATIENT care - Abstract
Malnutrition, muscle loss, and cachexia are prevalent in cancer and remain key challenges in oncology today. These conditions are frequently underrecognized and undertreated and have devastating consequences for patients. Early nutrition screening/assessment and intervention are associated with improved patient outcomes. As a multifaceted disease, cancer requires multimodal care that integrates supportive interventions, specifically nutrition and exercise, to improve nutrient intake, muscle mass, physical functioning, quality of life, and treatment outcomes. An integrated team of healthcare providers that incorporates societies' recommendations into clinical practice can help achieve the best possible outcomes. A multidisciplinary panel of experts in oncology, nutrition, exercise, and medicine participated in a 2-day virtual roundtable in October 2020 to discuss gaps and opportunities in oncology nutrition, alone and in combination with exercise, relative to current evidence and international societies' recommendations. The panel recommended five principles to optimize clinical oncology practice: (1) position oncology nutrition at the center of multidisciplinary care; (2) partner with colleagues and administrators to integrate a nutrition care process into the multidisciplinary cancer care approach; (3) screen all patients for malnutrition risk at diagnosis and regularly throughout treatment; (4) combine exercise and nutrition interventions before (e.g., prehabilitation), during, and after treatment as oncology standard of care to optimize nutrition status and muscle mass; and (5) incorporate a patient-centered approach into multidisciplinary care. [ABSTRACT FROM AUTHOR]
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- 2022
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13. Dealing with the lack of evidence to treat depression in older patients with cancer: French Societies of Geriatric Oncology (SOFOG) and PsychoOncology (SFFPO) position paper based on a systematic review.
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Beauplet, Bérengère, Soulie, Ophélie, Niemier, Jean-Yves, Pons-Peyneau, Cécile, Belhadi, Drifa, Couffignal, Camille, and Fossey-Diaz, Virginie
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OLDER patients , *GERIATRIC oncology , *MEDICAL personnel , *CANCER patients , *MENTAL depression - Abstract
Introduction: Depression symptoms, frequently diagnosed in older patients with cancer, impacts on oncological treatment feasibility. The Francophone Society of Geriatric Oncology (SOFOG) has initiated a systematic review on depression treatment in older patients with cancer, to advocate guidelines. Data sources: Medline via PubMed, Embase, CENTRAL. Methods: We included randomized and non-randomized controlled trials, reviews and meta-analysis, retrospective and prospective cohort studies, qualitative studies, and guidelines published between January 2013 and December 2018 that involved depression with cancer in which the entire sample or a sub-group aged 65 and above. Efficacy and tolerance of depression treatment were examined, as a primary or secondary outcome, among articles published in French or English. Results: Of 3171 references, only seven studies met our eligibility criteria. This systematic review reveals a lack of evidence-based knowledge in this field, preventing from making any recommendations on drug and non-drug therapies. It has highlighted the need for multidisciplinary collaboration with the French and Francophone Society of Psycho-Oncology. Conclusion: In clinical practice, we advise health professionals to use the screening process not as a result but rather as an opportunity to engage with the patient and also to question the need for antidepressants and non-drug therapies. [ABSTRACT FROM AUTHOR]
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- 2021
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14. Guidance for establishing an integrative oncology service in the Australian healthcare setting-a discussion paper.
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Grant, Suzanne J., Hunter, Jennifer, Bensoussan, Alan, and Delaney, Geoff P.
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ONCOLOGY , *MEDICAL care , *TRADITIONAL medicine , *ALTERNATIVE medicine , *CANCER patient care - Abstract
There is an obvious mismatch between the high reported rates of use of traditional and complementary medicines (T&CM) by Australian cancer patients and cancer survivors and the low numbers of Australian cancer services integrating T&CM. An estimated 65% of Australian cancer patients use at least one form of T&CM. Over half use T&CM in conjunction with conventional cancer therapy. Yet, less than 20% of Australian hospital cancer care facilities provide access to T&CM. This compares to around 70% of UK cancer care facilities offering at least one T&CM therapy. Barriers to developing integrative oncology services include determining an appropriate service model and revenue structure; concerns with ethical and legal issues such as regulations and credentialing; and inadequate high-quality scientific evidence demonstrating safety and effectiveness, including concerns about the possibility of adversely affecting chemotherapy or radiotherapy treatment. This paper aims to provide general guidance and practical strategies for those seeking to develop integrative oncology services in Australian cancer care facilities. [ABSTRACT FROM AUTHOR]
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- 2018
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15. The preventive care of medication-related osteonecrosis of the jaw (MRONJ): a position paper by Italian experts for dental hygienists.
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Mauceri, Rodolfo, Coniglio, Rita, Abbinante, Antonia, Carcieri, Paola, Tomassi, Domenico, Panzarella, Vera, Di Fede, Olga, Bertoldo, Francesco, Fusco, Vittorio, Bedogni, Alberto, and Campisi, Giuseppina
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PREVENTIVE health services ,HYGIENISTS ,MAXILLOFACIAL surgery ,MEDICAL care ,MEDICAL personnel - Abstract
Purpose: The prevention and early diagnosis of medication-related osteonecrosis of the jaw (MRONJ) is fundamental to reducing the incidence and progression of MRONJ. Many in the field believe that dental hygienists should play an integral role in primary and secondary MRONJ prevention. However, to date, very few publications in the literature have proposed standardised MRONJ protocols, which are dedicated to dental hygienists. The aim of this study was to provide guidance to the health care providers managing MRONJ.Methods: The expert opinion in this study was developed by dental hygienists from the main Italian technical-scientific associations (Italian Dental Hygienists Association, AIDI and National Union of Dental Hygienists, UNID) and authors of the latest Italian recommendations regarding MRONJ from the field of dentistry and maxillofacial surgery.Results: The oral care protocol outlined in this position paper is focused on the role of dental hygienist in patients at risk or affected by MRONJ, and it regards 3 main issues: primary prevention, secondary prevention and supporting the treatment of MRONJ. Each issue contains easy-to-apply indications and procedures, as described by the authors, regarding the role of the dental hygienist.Conclusion: Referring to the main issues under consideration (primary prevention, secondary prevention and the treatment of MRONJ), a clinical examination of periodontal tissue is critical in preventing MRONJ. It is the opinion of the authors of this study that the application of a periodontal screening score is fundamental in defining personalised strategies for patients at risk of MRONJ. By means of these basic procedures, a protocol for assisting the health care provider and the presentation of a practical approach for patients at risk or affected by MRONJ are described in this study. [ABSTRACT FROM AUTHOR]- Published
- 2022
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16. Basic oral care for hematology-oncology patients and hematopoietic stem cell transplantation recipients: a position paper from the joint task force of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) and the European Society for Blood and Marrow Transplantation (EBMT)
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Elad, Sharon, Raber-Durlacher, Judith, Brennan, Michael, Saunders, Deborah, Mank, Arno, Zadik, Yehuda, Quinn, Barry, Epstein, Joel, Blijlevens, Nicole, Waltimo, Tuomas, Passweg, Jakob, Correa, M., Dahllöf, Göran, Garming-Legert, Karin, Logan, Richard, Potting, Carin, Shapira, Michael, Soga, Yoshihiko, Stringer, Jacqui, and Stokman, Monique
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ORAL hygiene , *HEMATOPOIETIC stem cell transplantation , *HEMATOLOGY , *ONCOLOGY , *CANCER chemotherapy ,MORTALITY risk factors - Abstract
Purpose: Hematology-oncology patients undergoing chemotherapy and hematopoietic stem cell transplantation (HSCT) recipients are at risk for oral complications which may cause significant morbidity and a potential risk of mortality. This emphasizes the importance of basic oral care prior to, during and following chemotherapy/HSCT. While scientific evidence is available to support some of the clinical practices used to manage the oral complications, expert opinion is needed to shape the current optimal protocols. Methods: This position paper was developed by members of the Oral Care Study Group, Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) and the European Society for Blood and Marrow Transplantation (EBMT) in attempt to provide guidance to the health care providers managing these patient populations. Results: The protocol on basic oral care outlined in this position paper is presented based on the following principles: prevention of infections, pain control, maintaining oral function, the interplay with managing oral complications of cancer treatment and improving quality of life. Conclusion: Using these fundamental elements, we developed a protocol to assist the health care provider and present a practical approach for basic oral care. Research is warranted to provide robust scientific evidence and to enhance this clinical protocol. [ABSTRACT FROM AUTHOR]
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- 2015
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17. Evaluation of electronic patient–reported outcome assessment in inpatient cancer care: a feasibility study.
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Salm, Hanna, Hentschel, Leopold, Eichler, Martin, Pink, Daniel, Fuhrmann, Stephan, Kramer, Michael, Reichardt, Peter, and Schuler, Markus K.
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Purpose: Patient-reported outcome (PRO) measures are increasingly important in evaluating medical care. The increased integration of technology within the healthcare systems allows for collection of PROs electronically. The objectives of this study were to Ashley et al. J Med Internet Res (2013) implement an electronic assessment of PROs in inpatient cancer care and test its feasibility for patients and Dawson et al. BMJ (2010) determine the equivalence of the paper and electronic assessment. Methods: We analyzed two arms from a study that was originally designed to be an interventional, three-arm, and multicenter inpatient trial. A self-administered questionnaire based on validated PRO-measures was applied and completed at admission, 1 week after, and at discharge. For this analysis — focusing on feasibility of the electronic assessment — the following groups will be considered: Group A (intervention arm) received a tablet version, while group B (control arm) completed the questionnaire on paper. A feasibility questionnaire, that was adapted from Ashley et al. J Med Internet Res (2013), was administered to group A. Results: We analyzed 103 patients that were recruited in oncology wards. ePRO was feasible to most patients, with 84% preferring the electronic over paper-based assessment. The feasibility questionnaire contained questions that were answered on a scale ranging from “1” (illustrating non achievement) to “5” (illustrating achieving goal). The majority (mean 4.24, SD.99) reported no difficulties handling the electronic tool and found it relatively easy finding time for filling out the questionnaire (mean 4.15, SD 1.05). There were no significant differences between the paper and the electronic assessment regarding the PROs. Conclusion: Results indicate that electronic PRO assessment in inpatient cancer care is feasible. [ABSTRACT FROM AUTHOR]
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- 2023
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18. Nurse-led support impact via a mobile app for breast cancer patients after surgery: a quasi-experimental study (step 2)
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Aydin, Aydanur and Gürsoy, Ayla
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- 2024
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19. Shedding light on the management of acute radiation dermatitis: insight from the MASCC Oncodermatology study group.
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Bonomo, Pierluigi and Wolf, Julie Ryan
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This paper highlights a collection of eleven recently published manuscripts on the prevention and management of acute radiation dermatitis. These meta-analyses provide additional evidence for the updated clinical practice guidelines by the Multinational Association of Supportive Care in Cancer (MASCC) Oncodermatology study group for prevention and management of acute radiation dermatitis. The collection of papers elucidate the currently available evidence on acute radiation dermatitis, highlighting consolidated knowledge, effective treatments, and proposed areas for future clinical trials. Overall, a total of 51 randomized controlled trials were retrieved and included for quantitative analysis of an initial systematic review of literature from 1946 to January 2023. Discussion of the clinical impact of various therapeutic interventions include: antiperspirant and deodorant use, barrier films and dressings, natural and miscellaneous agents, photobiomodulation therapy, topical corticosteroids, topical non-steroidal agents, skin hygiene and washing, as well as StrataXRT and Mepitel film in breast cancer patients. The comprehensive nature of the meta-analyses and their related findings may help reduce the discrepancies in in treatment of acute radiation dermatitis and facilitate consistency of therapeutic interventions employed in clinical practice worldwide. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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20. Necessity and influencing factors for integrating oral health in cancer care for older people: a narrative review.
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Anand, Shalya, Visser, Anita, Epstein, Joel B., and Jalovcic, Djenana
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Purpose: The number of older people with poor oral health diagnosed with cancer is increasing rapidly. However, integration of oral health in cancer care for older people to prevent or minimize oral health complications of cancer treatments is uncommon, except in head and neck oncology. The aim of this review is to describe the need, role of, and factors influencing the integration of oral health(care) into the treatment of older people with cancer. Methods: MEDLINE, CINAHL, PubMed, Scopus, and Web of Science databases were searched for papers published in the last 10 years that focus on oral health in older people diagnosed with cancer, the impact of oral health on cancer therapy, and integrated oral health in cancer treatment. Results: From 523 related papers, 68 publications were included and summarized as follows: (1) oral complications associated with cancer therapies, (2) the need for oral healthcare in older people with cancer, (3) the role of integration of oral health in cancer care, and (4) influencing factors such as ageism, interprofessional education and collaborations, oral healthcare workforce, oral health literacy, and financial considerations. Conclusion: Integration of oral healthcare is highly recommended for the overall well-being of older people with cancer to prevent, minimize, and manage complications in cancer treatment. However, oral healthcare has not been integrated in cancer care yet, except for head and neck cancers. This review identified a notable gap in the literature, highlighting the need for research on integration of oral healthcare in geriatric oncology. [ABSTRACT FROM AUTHOR]
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- 2024
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21. Adventure therapy for child, adolescent, and young adult cancer patients: a systematic review.
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Chan, Ying Tung, Lau, Hoi Yee, Chan, Wai Yan, Cheung, Chi Wo, Lui, Winnie, Chane-Thu, Yuk Sze Jacqueline, Dai, Wen Lam, To, Ka Ching, and Cheng, Hui Lin
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ADVENTURE therapy ,CANCER patients ,YOUNG adults ,TEENAGERS ,PSYCHOLOGICAL distress - Abstract
Purpose: This systematic review aimed to examine the evidence on adventure therapy (AT) intervention for child, adolescent, and young adult (AYA) cancer patients in order to inform the design of future research and clinical practice. Methods: This review included studies that tested the AT intervention among child and AYA cancer patients. Nine electronic databases (CINAHL, Cochrane Central Register of Controlled Trials, EMBase, Medline via EbscoHost, OpenGrey, PsycInfo, Web of Science, Scopus, and PubMed) were searched for English-language published studies using a quasi-experimental design, one-group pre-test–post-test experimental study design, or randomized controlled trial (RCT) from 1981 to May 2020. The methodological quality of the included studies was evaluated using JBI Critical Appraisal Checklists for RCTs and for Quasi-Experimental Studies by two researchers independently. A narrative synthesis of intervention characteristics and related health-related outcomes was performed. Results: Eight papers from seven studies were included in the review, namely four RCTs, two quasi-experimental study papers, and two one-group pre-test–post-test experimental study papers. Studies varied in the components and duration of AT. Medium to high methodological quality of included studies was noted in all study designs. Results showed the positive effects of AT on the physical activity, fatigue, psychological distress, and quality of life of child and AYA cancer patients. Conclusion: AT is a promising intervention that may improve a number of health-related outcomes in child and AYA cancer patients. Evidence-based AT interventions should be developed and incorporated as part of supportive care for the target population. [ABSTRACT FROM AUTHOR]
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- 2021
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22. The Lausanne Hospitality Model: a model integrating hospitality into supportive care.
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Lê Van, Kim, Arditi, Chantal, Terrier, Lohyd, Ninane, Françoise, Savoie, Annie, Rochat, Sylvie, Peytremann-Bridevaux, Isabelle, Eicher, Manuela, and Schaad, Béatrice
- Abstract
Purpose : Cancer care is undergoing a conceptual shift with the introduction of the principles of patient-centered care to support patients’ individual needs. These needs include those related to hospitality during cancer treatments. This paper aims to provide an extension of the supportive care framework by bringing in the hospitality approach inspired by the hotel industry. Method: The “Lausanne Hospitality Model,” integrating hospitality into supportive care, was developed through an iterative process, combining expertise in supportive care and health services research, communication, and the hotel industry. Results: This conceptual paper integrates hospitality and service sciences into the supportive care framework. The “Lausanne Hospitality Model” offers new insights into the notions of cancer journey, patient experience, services, and practices that may be involved when facilitating hospitality. While most concepts used in the model are based on prior research, they have not been combined previously. The model highlights the place of hospitality in the patient’s experience within cancer services and, by extension, its role in professional practice. Conclusion: Practices involved in the delivery of cancer care need to reinforce the importance attributed to hospitality services, as they impact patients’ experiences. By integrating the hospitality perspective into healthcare delivery and supportive care, this paper addresses previously theoretically overlooked aspects that impact patients’ experiences during cancer care. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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23. Photobiomodulation therapy for the prevention of acute radiation dermatitis: a systematic review and meta-analysis.
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Gobbo, Margherita, Rico, Victoria, Marta, Gustavo Nader, Caini, Saverio, Ryan Wolf, Julie, van den Hurk, Corina, Beveridge, Mara, Lam, Henry, Bonomo, Pierluigi, Chow, Edward, and Behroozian, Tara
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Purpose: Approximately 95% of patients undergoing radiotherapy (RT) experience radiation dermatitis (RD). Evidence has suggested that photobiomodulation therapy (PBMT) can stimulate skin renewal and minimize RD. The aim of the present paper was to investigate the efficacy of PBMT in RD prevention through a comprehensive literature review. Methods: A literature search of Ovid MEDLINE, Embase, and Cochrane databases was conducted from 1980 to March 2021 to identify RCT on the use of PBMT for RD prevention. Forest plots were developed using RevMan software to quantitatively compare data between studies. Results: Five papers were identified: four in breast and one in head and neck cancer patients. Patients receiving PBMT experienced less severe RD than the control groups after 40 Gray (Gy) of RT (grade 3 toxicity: Odds Ratio (OR): 0.57, 95% CI 0.14–2.22, p = 0.42) and at the end of RT (grade 0 + 1 vs. 2 + 3 toxicity: OR: 0.28, 95% CI 0.15–0.53, p < 0.0001). RT interruptions due to RD severity were more frequent in the control group (OR: 0.81, 95% CI 0.10–6.58, p = 0.85). Conclusion: Preventive PBMT may be protective against the development of severe grades of RD and reduce the frequency of RT interruptions. Larger sample sizes and other cancer sites at-risk of RD should be evaluated in future studies to confirm the true efficacy of PBMT, also in preventing the onset of RD and to finalize a standardized protocol to optimize the technique. At present, starting PBMT when RT starts is recommendable, as well as performing 2 to 3 laser sessions weekly. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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24. Supporting colorectal cancer survivors using eHealth: a systematic review and framework suggestion.
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Ayyoubzadeh, Seyed Mohammad, R. Niakan Kalhori, Sharareh, Shirkhoda, Mohammad, Mohammadzadeh, Niloofar, and Esmaeili, Marzieh
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CANCER survivors ,COLORECTAL cancer ,META-analysis ,PHYSICAL activity ,ELECTRONIC information resource searching ,ONLINE information services ,MEDICAL information storage & retrieval systems ,SYSTEMATIC reviews ,HEALTH status indicators ,QUALITY of life ,MEDLINE ,PALLIATIVE treatment ,TELEMEDICINE - Abstract
Purpose: eHealth could potentially support colorectal cancer survivors; however, little is known regarding the overall recent eHealth systems for colorectal cancer survivors. The present study was conducted to address which types of eHealth supports have been provided to colorectal cancer survivors in the past two decades.Methods: An electronic search was conducted in four databases including Scopus, PubMed, Embase, and Web of Science. The search query was based on two concepts: the first concept represented colorectal cancer and the second one comprised of information technology tools. The search was limited to 20 years (from 19 January 1999 to 19 January 2019). Obtained results were tabulated and represented as a framework.Results: Fifteen papers were included in this systematic review. Information including intervention type, eHealth tools, main features of the system, and outcomes were extracted from selected papers. Obtained results were characterized using a four-layer framework. This framework included layers of hardware, software, service (educating the patient, medication intake, physical activity, health status monitoring, hospital visit reminder, and discussion group), and outcome. Outcome layer was composed of the following domains: quality of life, psychological and cognitive, physical activity, physical functioning, symptoms, engagement, and the outcome of the process and IT tools.Conclusion: eHealth could provide useful services for supporting colorectal cancer survivors. Represented framework might be used for a better understanding of current technology and services provided to support these survivors. Also, this framework may be used as a basis for designing eHealth applications for colorectal cancer survivors after further validations. [ABSTRACT FROM AUTHOR]- Published
- 2020
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25. Advances in the treatment of malignant ascites in China.
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Zhang, Junzi, Qi, Zhaoxue, Ou, Wenjie, Mi, Xuguang, Fang, Yanqiu, Zhang, Wenqi, Yang, Zhen, Zhou, Ying, Lin, Xiuying, Hou, Junjie, and Yuan, Zhixin
- Abstract
Purpose: Malignant ascites (MA) often occurs in recurrent abdominal malignant tumors, and the large amount of ascites associated with cancerous peritonitis not only leads to severe abdominal distension and breathing difficulties, but also reduces the patient’s quality of life and ability to resist diseases, which usually makes it difficult to carry out anti-cancer treatment. The exploration of MA treatment methods is also a key link in MA treatment. This article is going to review the treatment of MA, to provide details for further research on the treatment of MA, and to provide some guidance for the clinical treatment of MA. Method: This review analyzes various expert papers and summarizes them to obtain the paper. Result: There are various treatment methods for MA, including systemic therapy and local therapy. Among them, systemic therapy includes diuretic therapy, chemotherapy, immunotherapy, targeted therapy, anti angiogenic therapy, CAR-T, and vaccine. Local therapy includes puncture surgery, peritoneal vein shunt surgery, acellular ascites infusion therapy, radioactive nuclide intraperitoneal injection therapy, tunnel catheter, and intraperitoneal hyperthermia chemotherapy. And traditional Chinese medicine treatment has also played a role in enhancing efficacy and reducing toxicity to a certain extent. Conclusion: Although there has been significant progress in the treatment of MA, it is still one of the clinical difficulties. Exploring the combination or method of drugs with the best therapeutic effect and the least adverse reactions to control MA is still an urgent problem to be solved. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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26. eHealth interventions to support colorectal cancer patients’ self-management after discharge from surgery—an integrative literature review.
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Husebø, Anne Lunde Marie, Søreide, Jon Arne, Kørner, Hartwig, Storm, Marianne, Wathne, Hege Bjøkne, Richardson, Alison, Morken, Ingvild Margreta, Urstad, Kristin Hjorthaug, Nordfonn, Oda Karin, and Karlsen, Bjørg
- Abstract
Introduction: Colorectal cancer (CRC) creates elevated self-management demands and unmet support needs post-discharge. Follow-up care through eHealth post-primary surgery may be an effective means of supporting patients’ needs. This integrative review describes the evidence regarding eHealth interventions post-hospital discharge focusing on delivery mode, user-interface and content, patient intervention adherence, impact on patient-reported outcomes and experiences of eHealth. Methods: A university librarian performed literature searches in 2021 using four databases. After screening 1149 records, the authors read 30 full-text papers and included and extracted data from 26 papers. Two authors analysed the extracted data using the ‘framework synthesis approach’. Results: The 26 papers were published between 2012 and 2022. The eHealth interventions were mainly delivered by telephone with the assistance of healthcare professionals, combined with text messages or video conferencing. The user interfaces included websites, applications and physical activity (PA) trackers. The interventions comprised the monitoring of symptoms or health behaviours, patient information, education and counselling. Evidence showed a better psychological state and improved PA. Patients reported high satisfaction with eHealth. However, patient adherence was inadequately reported. Conclusions: eHealth interventions may positively impact CRC patients’ anxiety and PA regardless of the user interface. Patients prefer technology combined with a human element. [ABSTRACT FROM AUTHOR]
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- 2024
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27. Utility of the Patient-Reported Outcomes Measurement Information System (PROMIS) to measure primary health outcomes in cancer patients: a systematic review.
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Tran, Thi Xuan Mai, Park, Jungeun, Lee, Joonki, Jung, Yuh-Seog, Chang, Yoonjung, and Cho, Hyunsoon
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HEALTH outcome assessment ,PATIENT reported outcome measures ,INFORMATION storage & retrieval systems ,CANCER patients ,MEDICAL personnel - Abstract
Objective: To systematically review the literature on how the Patient-Reported Outcomes Measurement Information System (PROMIS) measure system is used to assess patient-reported outcomes (PROs) in cancer patients. Methods: We conducted a systematic review following the PRISMA guidelines. Articles were identified through searches of PubMed, EMBASE, and additional manual review of the publications listed on the PROMIS website. We included studies measuring outcomes, including physical function, fatigue, pain, anxiety, and depression in cancer patients. Eligible articles included interventional and observational studies published in English between 2009 and 2019. Results: A total of 1789 records were identified and screened by three reviewers, 118 articles were reviewed in full text, and 42 articles met the inclusion criteria. The majority of studies used the PROMIS measure system to prospectively assess longitudinal changes in PROs; the number of measurements ranges from 2 to 4 with the time points of follow-up set at 3, 6, and 12 months after the baseline assessment. Depression and fatigue were the most frequently measured outcomes. Fixed-length short forms with four items were the most common measure types. A transition toward utilizing a web- or smartphone-based electronic tool was observed to limit the burden of the conventional paper-based survey to collect and store PROs. Conclusion: The PROMIS measure system is increasingly popular to measure PROs in cancer patients with acceptance of its various short forms and electronic-based systems to administer data electronically. Findings from this review highlight various aspects of PROMIS and may help health professionals in their choice of PRO tools for optimizing care and support for cancer patients. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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28. Pain characteristics in medication-related osteonecrosis of the jaws.
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Haviv, Yaron, Geller, Zehava, Mazor, Sigal, Sharav, Yair, Keshet, Naama, and Zadik, Yehuda
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PAIN management ,OSTEONECROSIS ,ORAL surgeons ,JAWS ,PAIN ,DIPHOSPHONATES ,RETROSPECTIVE studies - Abstract
Purpose: To characterise pain from medication-related osteonecrosis of the jaws (MRONJ) and the effects of antimicrobial treatment on it.Methods: Data from files of patients diagnosed with MRONJ according to the position paper of the American Association of Oral and Maxillofacial Surgeons (2014) and Multinational Association of Supportive Care in Cancer and American Society of Clinical Oncology (2019) were collected retrospectively, including gender, age, primary disease, bone-modifying agents (BMAs)/anti-angiogenics, administration route, involved jaw, location, and exposure size. The patients were treated according to the abovementioned position papers' recommendations, i.e. all patients who suffered from pain were staged as 2 or 3 and treated with systemic amoxicillin, or doxycycline or clindamycin in case of sensitivity, and local antiseptic and hygiene instructions.Results: Data from 77 MRONJ patients (aged 65.09 ± 11.9 years old) were analysed. Most (90.1%) received bisphosphonates for cancer (79%) and osteoporosis (17%). A total of 67.5% experienced pain; 36.5% had moderate-to-severe pain. Female gender was significantly associated with the presence of pain (p = 0.002). Osteonecrosis lesions after dento-alveolar surgery had a higher risk of pain development than spontaneous lesions (p = 0.045). Medical and oncologic background, type of pharmacotherapy, lesion size, and location were not associated with pain levels. Worse initial pain was significantly associated with better relief following MRONJ treatment (p = 0.045). Meaningful pain reduction (≥ 50%) was significantly correlated with initial pain severity (p = 0.0128, OR = 4.75).Conclusions: Pain from infection and inflammation often accompanies MRONJ. The presence of pain is correlated with longer BMAs pre-therapy and if surgery preceded the MRONJ. Persistency of the mild pain together with a resistance to common antimicrobial treatment, although not complete, is a feature that MRONJ pain shares with neuropathic-"like" pain, and requires further study and consideration during treatment. [ABSTRACT FROM AUTHOR]- Published
- 2021
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29. Collection of electronic patient-reported symptoms in patients with advanced cancer using Epic MyChart surveys.
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Zylla, Dylan M., Gilmore, Grace E., Steele, Grant L., Eklund, Justin P., Wood, Christina M., Stover, Angela M., and Shapiro, Alice C.
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ONCOLOGY nursing ,PATIENT satisfaction ,ELECTRONIC health records ,CANCER patients ,NURSING standards ,TELEPHONE calls ,TUMOR diagnosis ,PILOT projects ,FERRANS & Powers Quality of Life Index ,CLINICS ,QUALITY of life ,RESEARCH funding ,TUMORS ,PALLIATIVE treatment - Abstract
Background: Use of electronic patient-reported outcomes (ePROs) in routine cancer care can help identify troublesome symptoms and facilitate discussions between patients and clinicians and has been shown to improve patient satisfaction, quality of life, and survival.Methods: Eighty patients with stage IV non-hematologic malignancies on chemotherapy participated. Patient-Reported Symptom Monitoring (PRSM) surveys were sent every 14 days via the Epic MyChart system over a 12-week period. Surveys were offered via phone or paper if patients failed to complete the automated MyChart survey by day 16. Severe symptoms or concerning symptom trends were automatically highlighted in reports for clinic staff. Patients reporting severe symptoms were routed to oncology nursing triage for standard symptom care management.Results: Two hundred seventy-one surveys were sent during the 12-week study period. One hundred eighty-three surveys (66%) were completed, with 68% completed electronically via MyChart, 25% by paper, and 7% by phone call from a research coordinator. At least one severe symptom was reported on 36% of all surveys. However, most severe symptoms did not result in urgent triage follow-up because they were already being addressed and/or patients felt they were manageable. Patients and clinicians generally said the ePRO was efficient and helpful for addressing distressing symptoms and would use it in routine oncology care.Conclusion: ePROs can be integrated into the electronic health record using the Epic MyChart system. Patients and clinicians gave positive feedback on the system. Monitoring symptoms in real time may soon become part of standard oncology practice and requires seamless methods for collection. [ABSTRACT FROM AUTHOR]- Published
- 2020
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30. Systematic review of oral cryotherapy for the management of oral mucositis in cancer patients and clinical practice guidelines.
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Correa, M Elvira P, Cheng, Karis Kin Fong, Chiang, Karen, Kandwal, Abhishek, Loprinzi, Charles L, Mori, Takehiko, Potting, Carin, Rouleau, Tanya, Toro, Juan J, Ranna, Vinisha, Vaddi, Anusha, Peterson, Douglas E, Bossi, Paolo, Lalla, Rajesh V, and Elad, Sharon
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MUCOSITIS ,META-analysis ,COLD therapy ,ORAL cancer ,HEMATOPOIETIC stem cells ,STEM cell transplantation ,STOMATITIS treatment ,THERAPEUTIC use of antineoplastic agents ,STOMATITIS ,SYSTEMATIC reviews ,ANTINEOPLASTIC agents ,TUMORS ,ONCOLOGY - Abstract
Purpose: To update the 2013 Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) clinical practice guidelines on oral cryotherapy for the management of oral mucositis (OM) caused by cancer therapies.Methods: A systematic review was conducted by the Mucositis Study Group of MASCC/ISOO. The evidence for each intervention for specific cancer treatment modalities was assigned a level of evidence (LoE). The findings were added to the database used to develop the 2013 MASCC/ISOO clinical practice guidelines. Based on the LoE, the guidelines were set as: recommendation, suggestion, or no guideline possible.Results: A total of 114 papers were identified: 44 from PubMed and 70 from Web of Science. After abstract triage and merging with the 2013 database, 36 papers were reviewed. The LoE for prevention of OM with oral cryotherapy in patients undergoing autologous hematopoietic stem cell transplant using high-dose melphalan conditioning protocols was upgraded, and the guideline changed to recommendation. Additionally, the recommendation for prevention of OM with oral cryotherapy in patients receiving bolus 5-fluorouracil for the treatment of solid tumors was confirmed. No guidelines were possible for other clinical settings.Conclusions: The evidence supports recommendations for the use of oral cryotherapy for the prevention of OM for either (i) patients undergoing autologous hematopoietic stem cell transplant with high-dose melphalan conditioning protocols or (ii) patients receiving bolus 5-fluorouracil chemotherapy. [ABSTRACT FROM AUTHOR]- Published
- 2020
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31. Systematic review of growth factors and cytokines for the management of oral mucositis in cancer patients and clinical practice guidelines.
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Logan, Richard M., Al-Azri, Abdul Rahman, Bossi, Paolo, Stringer, Andrea M., Joy, Jamie K., Soga, Yoshihiko, Ranna, Vinisha, Vaddi, Anusha, Raber-Durlacher, Judith E., Lalla, Rajesh V., Cheng, Karis Kin Fong, Elad, Sharon, and Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO)
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GROWTH factors ,MUCOSITIS ,HEMATOPOIETIC stem cell transplantation ,META-analysis ,ORAL cancer ,STEM cell transplantation ,THERAPEUTIC use of cytokines ,THERAPEUTIC use of antineoplastic agents ,GRANULOCYTE-macrophage colony-stimulating factor ,STOMATITIS ,SYSTEMATIC reviews ,ANTINEOPLASTIC agents ,MEDICAL protocols ,TUMORS ,RECOMBINANT proteins - Abstract
Purpose: To update the clinical practice guidelines for the use of growth factors and cytokines for the prevention and/or treatment of oral mucositis (OM).Methods: A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO). The body of evidence for each intervention, in each cancer treatment setting, was assigned an evidence level. The findings were added to the database used to develop the 2014 MASCC/ISOO clinical practice guidelines. Based on the evidence level, the following guidelines were determined: recommendation, suggestion, and no guideline possible.Results: A total of 15 new papers were identified within the scope of this section and were merged with 51 papers that were reviewed in the previous guidelines update. Of these, 14, 5, 13, 2, and 1 were randomized controlled trials about KGF-1, G-CSF, GM-CSF, EGF, and erythropoietin, respectively. For the remaining agents there were no new RCTs. The previous recommendation for intravenous KGF-1 in patients undergoing autologous hematopoietic stem cell transplantation (HSCT) conditioned with high-dose chemotherapy and TBI-based regimens is confirmed. The previous suggestion against the use of topical GM-CSF for the prevention of OM in the setting of high-dose chemotherapy followed by autologous or allogeneic stem cell transplantation remains unchanged.Conclusions: Of the growth factors and cytokines studied for the management of OM, the evidence supports a recommendation in favor of KGF-1 and a suggestion against GM-CSF in certain clinical settings. [ABSTRACT FROM AUTHOR]- Published
- 2020
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32. Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patients and clinical practice guidelines.
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Saunders, Deborah P., Rouleau, Tanya, Cheng, Karis, Yarom, Noam, Kandwal, Abhishek, Joy, Jamie, Bektas Kayhan, Kivanc, van de Wetering, Marianne, Brito-Dellan, Norman, Kataoka, Tomoko, Chiang, Karen, Ranna, Vinisha, Vaddi, Anusha, Epstein, Joel, Lalla, Rajesh V., Bossi, Paolo, Elad, Sharon, and Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO)
- Subjects
MUCOSITIS ,META-analysis ,ORAL cancer ,CANCER pain ,CANCER patients ,ANALGESICS ,THERAPEUTIC use of antineoplastic agents ,HEAD tumors ,STOMATITIS ,ANESTHETICS ,SYSTEMATIC reviews ,ANTI-infective agents ,ANTINEOPLASTIC agents ,MEDICAL protocols ,NECK tumors - Abstract
Purpose: To update the clinical practice guidelines for the use of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the prevention and/or treatment of oral mucositis (OM).Methods: A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO). The body of evidence for each intervention, in each cancer treatment setting, was assigned an evidence level. The findings were added to the database used to develop the 2014 MASCC/ISOO clinical practice guidelines. Based on the evidence level, the following guidelines were determined: Recommendation, Suggestion, and No Guideline Possible.Results: A total of 9 new papers were identified within the scope of this section, adding to the 62 papers reviewed in this section previously. A new Suggestion was made for topical 0.2% morphine for the treatment of OM-associated pain in head and neck (H&N) cancer patients treated with RT-CT (modification of previous guideline). A previous Recommendation against the use of sucralfate-combined systemic and topical formulation in the prevention of OM in solid cancer treatment with CT was changed from Recommendation Against to No Guideline Possible. Suggestion for doxepin and fentanyl for the treatment of mucositis-associated pain in H&N cancer patients was changed to No Guideline Possible.Conclusions: Of the agents studied for the management of OM in this paper, the evidence supports a Suggestion in favor of topical morphine 0.2% in H&N cancer patients treated with RT-CT for the treatment of OM-associated pain. [ABSTRACT FROM AUTHOR]- Published
- 2020
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33. Electronic processing of papers.
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Julia Heidelmann and Hans-Jörg Senn
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- 2004
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34. Sepsis surveillance in patients with head-and-neck cancer undergoing chemo-radiation
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Babu, Ajay, Noel Alexander F, Hadrian, Muzumder, Sandeep, Srikantia, Nirmala, and Udayashankar, Avinash H.
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- 2024
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35. Bridging the gap — Establishing a dental-oncology service in a cancer centre
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Byrne, Harriet, Curtin, Claire, Weadick, Catherine S., Riordáin, Rícheal Ní, and O’Reilly, Seamus
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- 2024
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36. Pilot trial testing the effects of exercise on chemotherapy-induced peripheral neurotoxicity (CIPN) and the interoceptive brain system
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Kleckner, Ian R., Manuweera, Thushini, Lin, Po-Ju, Chung, Kaitlin H., Kleckner, Amber S., Gewandter, Jennifer S., Culakova, Eva, Tivarus, Madalina E., Dunne, Richard F., Loh, Kah Poh, Mohile, Nimish A., Kesler, Shelli R., and Mustian, Karen M.
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- 2024
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37. Trajectory patterns and factors associated with acceptance of disability in young and middle-aged breast cancer patients: a longitudinal study
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Sun, Shihao, Zhu, Mengyao, He, Haiyan, Chen, Lili, Luo, Chunhong, Zhang, Yiheng, Zhang, Ni, Zhang, Baoyi, and Zhang, Meifen
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- 2024
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38. Therapeutic potential of twenty-first century music for cancer survivorship: from music and conceptual metaphor perspectives to a synergetic effect approach.
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Nwankwo, James Chike and Nagornaya, Alexandra
- Abstract
This paper examines the therapeutic potential of twenty-first century music as a means of supplementary therapeutic care for cancer survivorship. It presents a study of songs by Rihanna, Beyoncé, Adele, Coldplay, and Imagine Dragons, which combines the analysis of relevant music features and conceptual metaphors in the lyrics to examine the effect of the songs on the audience. The main aim of this study was to highlight the emotional and cognitive impact of these songs on listeners and identify their potential role in improving the psychological condition of patients with cancer who are downtrodden or reeling from the pain of surgery, chemotherapy, and side effects of treatment. This article adopts the conceptual metaphorical framework proposed by Lakoff and Johnson (1980) and the metaphor identification procedure (MIP) (Pragglejazz group, 2007) to examine the targeted use of metaphors features in the lyrics of the selected songs. The findings show that although there is a therapeutic potential associated with the songs analyzed, there are also potential risks for patients with cancer. “”. [ABSTRACT FROM AUTHOR]
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- 2024
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39. A web-based knowledge database to provide evidence-based information to cancer patients: Utilization within the PIKKO study.
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Schneider, Nico, Altmann, Uwe, Brandt, Florian, Hübner, Jutta, Strauss, Bernhard, and Keinki, Christian
- Abstract
Purpose: Cancer is associated with an urgent need for understandable and reliable information, which is often not satisfied by information available online. Therefore, as part of the PIKKO project, a web-based knowledge database (WDB) was introduced to provide cancer patients with quality-assured, evidence-based information. This paper aims to provide insights into the usage (Who? How? What?) and the effects regarding health literacy of the WDB. Methods: A patient survey and automatically generated logfile data were evaluated. Two user groups, patients and patient navigators (PNs), were compared. Results: The 13 PNs were responsible for 1/3 of all accesses over the entire duration of the project. The 413 patients used WDB twice on average and spent an average of 12 min per session online (PNs: 9 min per session, more frequently). The top 3 topics of interest were ‘therapy’, ‘nutrition’ and ‘carcinogenesis’ for the patients, and ‘therapy’, ‘naturopathy’ and ‘legal regulations/support’ for the PNs. Of the patients surveyed, 69% said that WDB was helpful in making informed decisions, 76% found the information they wanted and 90% thought WDB was an appropriate way to provide information. Conclusion: Our WDB provided important information about cancer and its treatment on a digital way both, to patients and PNs. In routine cancer care, the WDB can improve health literacy and informed decision-making. Trial registration: This study was retrospectively registered in the German Clinical Trial Register under DRKS00016703 (21 Feb 2019, retrospectively registered). [ABSTRACT FROM AUTHOR]
- Published
- 2024
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40. Comparing the risk of severe oral mucositis associated with methotrexate as graft-versus host-disease prophylaxis to other immunosuppressive prophylactic agents in hematopoietic cell transplantation: a systematic review and meta-analysis.
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Al-Jamaei, Aisha A. H., Epstein, Joel B., de Visscher, Jan G. A. M., Spielberger, Ricardo T., Nakamura, Ryotaro, and Raber-Durlacher, Judith E.
- Abstract
Purpose: This study examines the risk of severe oral mucositis (SOM) in graft-versus-host disease prophylaxis (GVHD) compared to other agents in hematopoietic cell transplantation patients. Methods: A comprehensive search of four databases, including PubMed, Embassy, Web of Science, and Scopus, was conducted to identify studies reporting frequency and severity of oral mucositis in association with GVHD prophylactic regimens. RevMan 5.4 was used to perform the meta-analysis. Risk of bias assessment was carried out using the Rob-2 tool for randomized clinical trials (RCTs) and ROBINS-I tool for observational studies. Results: Twenty-five papers, including 11 RCTs and 14 observational studies, met the inclusion criteria. The pooled results from eight RCTs showed a higher risk of SOM in patients receiving MTX or MTX-inclusive GVHD prophylaxis versus non-MTX alternatives (RR = 1.50, 95% CI [1.20, 1.87], I2 = 36%, P = 0.0003). Mycophenolate mofetil (MMF) and post-transplant cyclophosphamide (Pt-Cy) consistently showed lower risk of mucositis than MTX. Folinic acid (FA) rescue and mini-dosing of MTX were associated with reduced oral mucositis severity. Conclusion: Patients receiving MTX have a higher SOM risk compared to other approaches to prevent GVHD, which should be considered in patient care. When appropriate, MMF, FA, and a mini-dose of MTX may be an alternative that is associated with less SOM. This work also underlines the scarcity of RCTs on MTX interventions to provide the best evidence-based recommendations. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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41. Preliminary effects of a yoga intervention for lung cancer dyads: benefits for care partners.
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Leng, Qian L., Lyons, Karen S., Winters-Stone, Kerri M., Medysky, Mary E., Dieckmann, Nathan F., Denfeld, Quin E., and Sullivan, Donald R.
- Abstract
Purpose: Lung cancer is a disease with high mortality and morbidity, impacting both the patient and their closest contact, referred to in this paper as their care partner. There is limited evidence on how to support mental health and quality of life (QOL) for patient-care partner dyads during cancer treatment. This pilot study examines yoga as an intervention to improve well-being for the dyad. Methods: A single-group, 12-week pilot trial of yoga for patients and their care partners recruited from two hospitals during cancer treatment (N = 23 patient-partner dyads or 46 individuals). Most care partners were spouses (70%), with the remainder being adult children (22%), a sibling (4%), or a friend (4%). Descriptive statistics, Cohen’s d effect sizes, and paired t-tests for validated psychosocial measures were calculated at baseline and 12 weeks. Results: Sixty-five percent of dyads (N = 13) completed the study, with withdrawals mostly due to disease progression. Among care partners, there was a decrease in depression symptomology on the PHQ-8 (p = 0.015, Cohen’s d = 0.96) and improvement in QOL on the Caregiver QOL-Cancer scale (p = 0.001, Cohen’s d = 0.61). Fifty percent of dyads experienced concordant improvement in depressive symptoms and 77% in QOL. Conclusion: Patient-partner yoga is a promising intervention for improving mental health and QOL for patient-partner dyads among lung cancer survivors. This study demonstrates yoga to be acceptable, feasible, and with high concordance within patient-partner dyads for improvements in QOL. Yoga shows promise for patients and care partners to alleviate the negative psychosocial impacts of lung cancer, though more research is needed to confirm effects. Trial registration: ClinicalTrials.gov, NCT03649737, 12/9/2020. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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42. Health-related quality of life in rural cancer survivors compared with their urban counterparts: a systematic review.
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Latham, S., Leach, M. J., White, V. M., Webber, K., Jefford, M., Lisy, K., Davis, N., Millar, J. L., Evans, S., Emery, J. D., IJzerman, M., and Ristevski, E.
- Abstract
Purpose: We conducted a systematic review to describe health-related quality of life (HRQOL) in rural cancer survivors (RCS), and compare HRQOL between RCS and urban cancer survivors (UCS). Method: We searched Medline, Embase, CINAHL Plus, and PsycINFO for studies with HRQOL in adult cancer survivors living in rural, regional, remote, and urban areas, who had completed definitive primary cancer treatment, without evidence of residual disease. Where available, we used normative and clinically important values to ascribe meaning to HRQOL data. Findings: Fifteen studies (16 papers) were included. Most were from the US (n = 8) and reported on breast cancer survivors (n = 9). Six HRQOL instruments, collecting data across 16 domains, were used. Three instruments were specific to the survivorship phase. Normative and clinical data were available for 12 studies. Compared with normative populations, RCS had clinically worse physical HRQOL (6/12 studies), better social/family (5/7), and functional (3/6) HRQOL, and there were no differences in emotional or/mental HRQOL (9/12). In six studies with rural–urban comparator groups and normative and clinically important data, RCS and UCS had clinically worse physical (3/6 and 2/6, respectively) and better social/family (3/4 and 2/4 studies, respectively) HRQOL than normative populations. Functional HRQOL was better in RCS (2/4 studies) than UCS and normative populations. In 3/6 studies, there were no clinical differences in emotional or/mental HRQOL between RCS, UCS, and normative populations. Conclusion: Overall, HRQOL is not clearly better or worse in RCS than UCS. Future research should include different tumor types, rural residents, and survivorship-specific HRQOL instruments. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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43. Methodology for the MASCC/ISOO Mucositis Clinical Practice Guidelines Update.
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Bowen, J., Elad, S., Hutchins, R., and Lalla, R.
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CANCER treatment complications ,GUIDELINES ,PHYSICIAN practice patterns ,ORAL diseases ,ONCOLOGY ,PREVENTION ,THERAPEUTICS - Abstract
Members of the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) recently completed the process of updating the MASCC/ISOO Clinical Practice Guidelines for the prevention and treatment of mucositis. These guidelines, originally published in 2004, and last updated in 2007, provide clinicians with objective, evidence-based recommendations for the management of mucositis secondary to cancer therapy. This brief paper describes the methodology used to conduct the most recent systematic review in 2011, and develop new guidelines, providing the basis for the update. The overriding aims of the process were to assess evidence of effectiveness of interventions for the prevention and treatment of mucositis and to produce clinical practice guidelines for the management of mucositis using best available evidence. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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44. The effect of hematopoietic stem cell transplantation on patient-reported subjective oral dryness: a systematic review focusing on prevalence, severity and distress.
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Bulthuis, Marjolein S., van Gennip, Lucky L. A., Bronkhorst, Ewald M., Blijlevens, Nicole M. A., Huysmans, Marie-Charlotte D. N. J. M., van Leeuwen, Stephanie J. M., and Thomas, Renske Z.
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HEMATOPOIETIC stem cell transplantation - Abstract
Objective: The aim of the present systematic review is to assess the prevalence and severity of and distress caused by xerostomia over time in adult hematopoietic stem cell transplantation (HSCT) recipients. Methods: PubMed, Embase, and the Cochrane Library were searched for papers published between January 2000 and May 2022. Clinical studies were included if patient-reported subjective oral dryness was reported in adult autologous or allogeneic HSCT recipients. Risk of bias was assessed according to a quality grading strategy published by the oral care study group of the MASCC/ISOO, resulting in a score between 0 (highest risk of bias) and 10 (lowest risk of bias). Separate analysis focused on autologous HSCT recipients, allogeneic HSCT recipients receiving a myeloablative conditioning (MAC), and those receiving a reduced intensity conditioning (RIC). Results: Searches yielded 1792 unique records; 22 studies met the inclusion criteria. The quality scores ranged between 1 and 7, with a median score of 4. The prevalence, severity, and distress of xerostomia increased shortly after HSCT. Severity of xerostomia in allogeneic MAC recipients was higher compared to allogeneic RIC recipients 2–5 months post-HSCT (mean difference: 18 points on 0–100 scale, 95% CI: 9–27); after 1–2 years, there was no significant difference anymore. Conclusion: The prevalence of xerostomia in HSCT recipients is high in comparison to the general population. The severity of complaints is raised during the first year post-HSCT. The intensity of the conditioning plays a key role in the short-term development of xerostomia, while factors affecting the recovery in the long term remain largely unknown. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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45. A burden shared: the financial, psychological, and health-related consequences borne by family members and caregivers of people with cancer in India.
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Ranganathan, Sruthi, Tomar, Vivek, Chino, Fumiko, Jain, Bhav, Patel, Tej A., Dee, Edward Christopher, and Mathew, Aju
- Abstract
In India, approximately 1.4 million new cases of cancer are recorded annually, with 26.7 million people living with cancer in 2021. Providing care for family members with cancer impacts caregivers’ health and financial resources. Effects on caregivers’ health and financial resources, understood as family and caregiver “financial toxicity” of cancer, are important to explore in the Indian context, where family members often serve as caregivers, in light of cultural attitudes towards family. This is reinforced by other structural issues such as grave disparities in socioeconomic status, barriers in access to care, and limited access to supportive care services for many patients. Effects on family caregivers’ financial resources are particularly prevalent in India given the increased dependency on out-of-pocket financing for healthcare, disparate access to insurance coverage, and limitations in public expenditure on healthcare. In this paper, we explore family and caregiver financial toxicity of cancer in the Indian context, highlighting the multiple psychosocial aspects through which these factors may play out. We suggest steps forward, including future directions in (1) health services research, (2) community-level interventions, and (3) policy changes. We underscore that multidisciplinary and multi-sectoral efforts are needed to study and address family and caregiver financial toxicity in India. [ABSTRACT FROM AUTHOR]
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- 2023
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46. Cost-utility analysis of a supervised exercise intervention for women with early-stage endometrial cancer.
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Wang, Yufan, McCarthy, Alexandra L, and Tuffaha, Haitham
- Abstract
Purpose: Cardiovascular disease (CVD) is the leading cause of death after treatment for endometrial cancer (EC). There is clinical evidence that exercise significantly reduces the risks of CVD and cancer recurrence in this population; however, it is unclear whether there is value for money in integrating exercise into cancer recovery care for women treated for EC. This paper assesses the long-term cost-effectiveness of a 12-week supervised exercise intervention, as compared with standard care, for women diagnosed with early-stage EC. Method: A cost-utility analysis was conducted from the Australian health system perspective for a time horizon of 5 years. A Markov cohort model was designed with six mutually exclusive health states: (i) no CVD, (ii) post-stroke, (iii) post-coronary heart disease (CHD), (iv) post-heart failure, (v) post-cancer recurrence, and (vi) death. The model was populated using the best available evidence. Costs and quality-adjusted life years (QALYs) were discounted at 5% annual rate. Uncertainty in the results was explored using one-way and probabilistic sensitivity analyses (PSA). Result: The incremental cost of supervised exercise versus standard care was AUD $358, and the incremental QALY was 0.0789, resulting in an incremental cost-effectiveness ratio (ICER) of AUD $5184 per QALY gained. The likelihood that the supervised exercise intervention was cost-effective at a willingness-to-pay threshold of AUD $50,000 per QALY was 99.5%. Conclusion: This is the first economic evaluation of exercise after treatment for EC. The results suggest that exercise is cost-effective for Australian EC survivors. Given the compelling evidence, efforts could now focus on the implementation of exercise as part of cancer recovery care in Australia. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
47. Commentary: Quality nutrition care is integral to the Oncology Care Model.
- Author
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Arensberg, Mary Beth, Besecker, Beth, Weldishofer, Laura, and Drawert, Susan
- Subjects
CANCER treatment ,DIET therapy ,MEDICARE ,NUTRITION ,ONCOLOGY nursing ,FINANCIAL accountability ,FINANCIAL performance - Abstract
The Oncology Care Model (OCM) is a US Centers for Medicare & Medicaid Services (CMS) specialty model implemented in 2016, to provide higher quality, more highly coordinated oncology care at the same or lower costs. Under the OCM, oncology clinics enter into payment arrangements that include financial and performance accountability for patients receiving chemotherapy treatment. In addition, OCM clinics commit to providing enhanced services to Medicare beneficiaries, including care coordination, navigation, and following national treatment guidelines. Nutrition is a component of best-practice cancer care, yet it may not be addressed by OCM providers even though up to 80% of patients with cancer develop malnutrition and poor nutrition has a profound impact on cancer treatment and survivorship. Only about half of US ambulatory oncology settings screen for malnutrition, registered dietitian nutritionists (RDNs) are not routinely employed by oncology clinics, and the medical nutrition therapy they provide is often not reimbursed. Thus, adequate nutrition care in US oncology clinics remains a gap area. Some oncology clinics are addressing this gap through implementation of nutrition-focused quality improvement programs (QIPs) but many are not. What is needed is a change of perspective. This paper outlines how and why quality nutrition care is integral to the OCM and can benefit patient health and provider outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
48. Oral white lesion in patients post-hematopoietic stem cell transplantation: a case series demonstrating the diagnostic dilemma.
- Author
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Pukhalskaya, Tatsiana, Smoller, Bruce R, Becker, Michael, Maly, Alexander, Zadik, Yehuda, and Elad, Sharon
- Subjects
STEM cell transplantation ,GRAFT versus host disease ,DIAGNOSIS - Abstract
The current National Institutes of Health (NIH) consensus paper excluded "white hyperkeratotic plaque" from the diagnostic criteria for oral chronic graft-versus-host disease (cGVHD) in order to ensure malignant transformation is not overlooked. Therefore, an isolated oral white plaque is recommended to be subjected to biopsy and pathologic examination. The cases described in this paper shed a new light on the clinical approach to oral white plaque post-hematopoietic stem cell transplantation. The objectives of this article are to demonstrate that a white plaque does not contradict a diagnosis of oral cGVHD, and to highlight the clinical considerations for taking a biopsy. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
49. Development of an integrated model of care for allogeneic stem cell transplantation facilitated by eHealth—the SMILe study.
- Author
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Leppla, Lynn, Schmid, Anja, Valenta, Sabine, Mielke, Juliane, Beckmann, Sonja, Ribaut, Janette, Teynor, Alexandra, Dobbels, Fabienne, Duerinckx, Nathalie, Zeiser, Robert, Engelhardt, Monika, Gerull, Sabine, De Geest, Sabina, the SMILe study team, Bolliger, Dora, Chalandon, Yves, De DGeest, Sabina, Degen, Sabine, Fürmann, Margerita, and Grossmann, Florian
- Subjects
STEM cell transplantation ,INTEGRATIVE medicine ,AGILE software development ,SCIENTIFIC computing ,CHRONIC care model ,MEDICAL software ,INFECTION - Abstract
Purpose: Allogeneic stem cell transplantation would benefit from re-engineering care towards an integrated eHealth-facilitated care model. With this paper we aim to: (1) describe the development of an integrated care model (ICM) in allogeneic SteM-cell-transplantatIon faciLitated by eHealth (SMILe) by combining implementation, behavioral, and computer science methods (e.g., contextual analysis, Behavior Change Wheel, and user-centered design combined with agile software development); and (2) describe that model's characteristics and its application in clinical practice. Methods: The SMILe intervention's development consisted of four steps, with implementation science methods informing each: (1) planning its set-up within a theoretical foundation; (2) using behavioral science methods to develop the content; (3) choosing and developing its delivery method (human/technology) using behavioral and computer science methods; and (4) describing its characteristics and application in clinical practice. Results: The SMILe intervention is embedded within the eHealth enhanced Chronic Care Model, entailing four self-management intervention modules, targeting monitoring and follow-up of important medical and symptom-related parameters, infection prevention, medication adherence, and physical activity. Interventions are delivered partly face-to-face by a care coordinator embedded within the transplant team, and partly via the SMILeApp that connects patients to the transplant team, who can monitor and rapidly respond to any relevant changes within 1 year post-transplant. Conclusion: This paper provides stepwise guidance on how implementation, behavioral, and computer science methods can be used to develop interventions aiming to improve care for stem cell transplant patients in real-world clinical settings. This new care model is currently being tested in a hybrid I effectiveness-implementation trial. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
50. Lessons learned about virtual cancer care and distress screening in the time of COVID-19.
- Author
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Bultz, Barry D. and Watson, Linda
- Subjects
PSYCHOLOGICAL distress ,COVID-19 ,CANCER treatment ,COVID-19 pandemic ,CONTINUUM of care ,CANCER patient care ,MEDICAL screening - Abstract
Purpose: Cancer-related biopsychosocial distress is highly prevalent across the cancer care continuum. The implementation of screening patients for biopsychosocial distress has become a standard of practice in cancer care. With the presence of COVID-19, clinical care has shifted from in-person care to virtual care in many instances. One of the realities of COVID-19 is the significant decrease in screening patients for biopsychosocial symptom burden. Methods: Given that screening for distress has become an accreditation standard in many cancer programs, in the province of Alberta, Canada, all patients are screened for distress with every visit to the cancer centre. Given the presence of COVID-19, much of cancer care has shifted to being delivered virtually (through mediums such as Zoom). In this paper, we present pre- and post-COVID data on the frequency of distress screening and its impact on patient care. Results: A review of pre- and post-COVID-19 screening for distress questionnaires revealed that patients who received virtual care were less satisfied in the areas of emotional support and received less resources and referrals to supportive care. Conclusion: The rapid integration of virtual care without the inclusion of a standardized distress screening tool was akin to a natural experiment, as two groups (virtual and in-person clinic patients) received different levels of care and interventions. Without the inclusion of distress screening, the clinical conversation around symptoms is less likely to occur and results in fewer referrals to best practices in supportive care services. Lessons learned about virtual cancer care without distress screening in the time of COVID-19 demonstrates significantly fewer patients being screened for distress and subsequently has resulted in less supportive care referrals. Going forward, we must find ways to ensure that virtual cancer care continues to support distress screening and best patient-centric care. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
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