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Your search keyword '"Li, Linxin"' showing total 23 results
Start Over Author "Li, Linxin" Journal stroke (ovid)
23 results on '"Li, Linxin"'

1. C-Reactive Protein, Interleukin-6, and Vascular Recurrence After Stroke: An Individual Participant Data Meta-Analysis

Author

McCabe, John J., Walsh, Cathal, Gorey, Sarah, Harris, Katie, Hervella, Pablo, Iglesias-Rey, Ramon, Jern, Christina, Li, Linxin, Miyamoto, Nobukazu, Montaner, Joan, Pedersen, Annie, Purroy, Francisco, Rothwell, Peter M., Sudlow, Catherine, Ueno, Yuji, Vicente-Pascual, Mikel, Whiteley, William, Woodward, Mark, and Kelly, Peter J.

Published
2023
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2. Cardiovascular Events After Intracerebral Hemorrhage

Author

Li, Linxin and Murthy, Santosh B.

Abstract

Cardiovascular events after primary intracerebral hemorrhage (ICH) have emerged as a leading cause of poor functional outcomes and mortality during the long-term recovery after an ICH. These events encompass arterial ischemic events such as ischemic stroke and myocardial infarction, arterial hemorrhagic events that include recurrent ICH, and venous thrombotic events such as venous thromboembolism. The purpose of this review is to summarize the cardiovascular complications after ICH, epidemiology and associated risk factors, and their impact on ICH outcomes. Additionally, we will highlight possible pathophysiological mechanisms to explain the short- and long-term increased risks of ischemic and hemorrhagic events after ICH. Finally, we will highlight potential secondary stroke and venous thrombotic prevention strategies often not considered after ICH, balanced against the risk of ICH recurrence.

Published
2022
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9. Interleukin-6, C-Reactive Protein, and Recurrence After Stroke: A Time-Course Analysis of Individual-Participant Data

Author

McCabe, John J., Walsh, Cathal, Gorey, Sarah, Arnold, Markus, DeMarchis, Gian Marco, Harris, Katie, Hervella, Pablo, Iglesias-Rey, Ramon, Jern, Christina, Katan, Mira, Li, Linxin, Miyamoto, Nobukazu, Montaner, Joan, Purroy, Francisco, Rothwell, Peter M., Stanne, Tara M., Sudlow, Catherine, Ueno, Yuji, Vicente-Pascual, Mikel, Whiteley, William, Woodward, Mark, and Kelly, Peter J.

Published
2024
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17. Long-Term Risk of Stroke After Transient Global Amnesia in Two Prospective Cohorts

Author

Romoli, Michele, Tuna, Maria Assuncao, McGurgan, Iain, Li, Linxin, Giannandrea, David, Eusebi, Paolo, Tordo Caprioli, Federica, Lotti, Antonio, Salvadori, Nicola, Sarchielli, Paola, Gili, Alessio, Mosconi, Maria Giulia, Pellizzaro Venti, Michele, Stracci, Fabrizio, Ricci, Stefano, Paciaroni, Maurizio, Parnetti, Lucilla, Calabresi, Paolo, and Rothwell, Peter Malcolm

Abstract

Supplemental Digital Content is available in the text.

Published
2019
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19. Pathogenic Ischemic Stroke Phenotypes in the NINDS-Stroke Genetics Network

Author

Ay, Hakan, Arsava, Ethem Murat, Andsberg, Gunnar, Benner, Thomas, Brown, Robert D., Chapman, Sherita N., Cole, John W., Delavaran, Hossein, Dichgans, Martin, Engström, Gunnar, Giralt-Steinhauer, Eva, Grewal, Raji P., Gwinn, Katrina, Jern, Christina, Jimenez-Conde, Jordi, Jood, Katarina, Katsnelson, Michael, Kissela, Brett, Kittner, Steven J., Kleindorfer, Dawn O., Labovitz, Daniel L., Lanfranconi, Silvia, Lee, Jin-Moo, Lehm, Manuel, Lemmens, Robin, Levi, Chris, Li, Linxin, Lindgren, Arne, Markus, Hugh S., McArdle, Patrick F., Melander, Olle, Norrving, Bo, Peddareddygari, Leema Reddy, Pedersén, Annie, Pera, Joanna, Rannikmäe, Kristiina, Rexrode, Kathryn M., Rhodes, David, Rich, Stephen S., Roquer, Jaume, Rosand, Jonathan, Rothwell, Peter M., Rundek, Tatjana, Sacco, Ralph L., Schmidt, Reinhold, Schürks, Markus, Seiler, Stephan, Sharma, Pankaj, Slowik, Agnieszka, Sudlow, Cathie, Thijs, Vincent, Woodfield, Rebecca, Worrall, Bradford B., and Meschia, James F.

Abstract

NINDS (National Institute of Neurological Disorders and Stroke)-SiGN (Stroke Genetics Network) is an international consortium of ischemic stroke studies that aims to generate high-quality phenotype data to identify the genetic basis of pathogenic stroke subtypes. This analysis characterizes the etiopathogenetic basis of ischemic stroke and reliability of stroke classification in the consortium.

Published
2014
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20. Validation of the Montreal Cognitive Assessment Versus Mini-Mental State Examination Against Hypertension and Hypertensive Arteriopathy After Transient Ischemic Attack or Minor Stroke

Author

Webb, Alastair J.S., Pendlebury, Sarah T., Li, Linxin, Simoni, Michela, Lovett, Nicola, Mehta, Ziyah, and Rothwell, Peter M.

Abstract

Lack of reduced cognitive impairment with blood pressure (BP) lowering in trials may reflect use of the Mini-Mental State Examination (MMSE), which is insensitive to mild cognitive impairment after cerebrovascular events compared with the Montreal Cognitive Assessment. We determined relationships between impairment on MMSE versus Montreal Cognitive Assessment (MoCA) with the major physiological determinant of vascular cognitive impairment: hypertension and hypertensive arteriopathy.

Published
2014
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21. Population-Based Case–Control Study of White Matter Changes on Brain Imaging in Transient Ischemic Attack and Ischemic Stroke

Author

Li, Linxin, Simoni, Michela, Küker, Wilhelm, Schulz, Ursula G., Christie, Sharon, Wilcock, Gordon K., and Rothwell, Peter M.

Abstract

White matter changes (WMC) are a common finding on brain imaging and are associated with an increased risk of ischemic stroke. They are most frequent in small vessel stroke; however, in the absence of comparisons with normal controls, it is uncertain whether WMC are also more frequent than expected in other stroke subtypes. Therefore, we compared WMC in pathogenic subtypes of ischemic stroke versus controls in a population-based study.

Published
2013
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22. Stroke Genetics Network (SiGN) Study

Author

Meschia, James F., Arnett, Donna K., Ay, Hakan, Brown, Robert D., Benavente, Oscar R., Cole, John W., Bakker, Paul I.W. de, Dichgans, Martin, Doheny, Kimberly F., Fornage, Myriam, Grewal, Raji P., Gwinn, Katrina, Jern, Christina, Conde, Jordi Jimenez, Johnson, Julie A., Jood, Katarina, Laurie, Cathy C., Lee, Jin-Moo, Lindgren, Arne, Markus, Hugh S., McArdle, Patrick F., McClure, Leslie A., Mitchell, Braxton D., Schmidt, Reinhold, Rexrode, Kathryn M., Rich, Stephen S., Rosand, Jonathan, Rothwell, Peter M., Rundek, Tatjana, Sacco, Ralph L., Sharma, Pankaj, Shuldiner, Alan R., Slowik, Agnieszka, Wassertheil-Smoller, Sylvia, Sudlow, Cathie, Thijs, Vincent N.S., Woo, Daniel, Worrall, Bradford B., Wu, Ona, Kittner, Steven J., Anderson, Christopher D., Andren, Kerstin, Andsberg, Gunnar, Arsava, Ethem, Barrett, Kevin M., Benner, Thomas, Bentley, Paul, Bevan, Steven, Biffi, Alessandro, Brenner, David, Chapman, Sherita, Cheng, Yu-Ching, Delavaran, Hossein, Deline, Christopher, Dziedzic, Tomasz, Gamble, Dale, Giralt, Eva, Grazer, Anja, Gschwendtner, Andreas, Hegge, Caityln, Heitsch, Laura, Helenius, Johanna, Holmegaard, Lukas, Huq, Mohammed, Irie, Robert E., Jackson, Rebecca, Katschnig, Petra, Katsnelson, Michael, Khoury, Naim, Kilinc, Selma, Kumar, Gyanendra, Labovitz, Daniel, Lanfranconi, Silvia, Langefeld, Carl D., Lemmens, Robin, Li, Linxin, Malik, Shaneela, Melander, Olle, Nordstrom, Sara, Norrving, Bo, Ois, Angel, Ossi, Raid, Peddareddygari, Leema Reddy, Pedersén, Annie, Pera, Joanna, Pucek, Mateusz, Rannikmae, Kristiina, Redfors, Petra, Rhodes, J. David, Ribasés, Marta, Saraf, Neha, Schuerks, Markus, Seiler, Stephan, Sheikh, Huma, Southerland, Andrew M, Sparks, Mary J., Stoegerer, Eva, Sunyer, Jordi, Temple, Ella, Valenti, Raffaella, Weir, David, Weissman, Darren, Woodfield, Rebecca, and Yiin, Gabriel S.C

Abstract

Meta-analyses of extant genome-wide data illustrate the need to focus on subtypes of ischemic stroke for gene discovery. The National Institute of Neurological Disorders and Stroke SiGN (Stroke Genetics Network) contributes substantially to meta-analyses that focus on specific subtypes of stroke.

Published
2013
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23. Abstract WMP103: Associations Between Multimorbidity At Stroke/transient Ischaemic Attack Onset With All-cause Mortality Are Not Explained By Blood Biomarkers: A Population-based Study

Author

Downer, Matthew B, Li, Linxin, Burgess, Annette I, duerden, julia M, and Rothwell, Peter

Abstract

Introduction:Multimorbidity is highly prevalent in patients with transient ischaemic attack (TIA) or stroke, and is associated with increased short- and long-term mortality thereafter. Underlying mechanisms behind this relationship are unclear, and it is unknown whether increased inflammatory or prothrombotic factors might explain increased mortality.Methods:Using the population-based Oxford Vascular Study (OXVASC), we used a panel of 16 blood biomarkers relating to inflammation (IL-6, CRP, NGAL, sTNF-R1), thrombosis/atherogenesis (TM, fibrinogen, vWF, P-Selectin, PZ, D-Dimer, Anti-PC, ADAMTS-13), and cardiac or neuronal cell damage (NT-proBNP, hFABP, NSE, BDNF). Samples were obtained at stroke/TIA onset, and patients were followed up to 10 years. Biomarker levels were log-transformed to facilitate analysis. Multimorbidity immediately prior to TIA/stroke onset was assessed using the Charlson Comorbidity Index (CCI). Partial correlations (age-adjusted) were obtained between CCI and log-biomarker levels. Crude and adjusted hazard ratios (HRs) for all-cause mortality were obtained using Cox models, censoring at 2, 5, and 10 years.Results:1297 participants (median age 75.2, interquartile range: 65.3 - 83.2) were recruited from 2002-2012. 596 patients (46.0%) had no CCI comorbidity, 266 (20.5%) had 1, and 435 (33.5%) had 2 or more. After adjustment for age, CCI was correlated with IL-6, NGAL, sTNF-R1, TM, fibrinogen, vWF, D-Dimer, NT-proBNP, and hFABP (all p<0.05). CCI was associated with all-cause death at 10 years follow up (HR 1.51, 95%CI 1.38 - 1.64). This association remained significant after adjustment for age, sex, and stroke severity (HR 1.37, 95%CI 1.26 - 1.49) and after further adjustment for inflammatory markers (HR 1.43, 95%CI 1.26 - 1.62), thrombotic/antiatherogenic markers (HR 1.37, 95%CI 1.20 - 1.56), or markers of cardiac or neuronal cell damage (HR 1.33, 95%CI 1.21 - 1.47). Censoring at 2 or 5 years follow-up provided similar estimates.Conclusion:Multimorbidity was predictive of all-cause mortality after TIA/stroke, but the association was not explained by our panel of biomarkers. Further work is needed to explain the excess risk of mortality associated with multimorbidity in stroke/TIA patients.

Published
2022
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