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Start Over Author "Laan, Sander W van der" Journal stroke (ovid)
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1. Deficiency of the Stroke Relevant HDAC9Gene Attenuates Atherosclerosis in Accord With Allele-Specific Effects at 7p21.1

Author

Azghandi, Sepiede, Prell, Caroline, Laan, Sander W. van der, Schneider, Manuela, Malik, Rainer, Berer, Kerstin, Gerdes, Norbert, Pasterkamp, Gerard, Weber, Christian, Haffner, Christof, and Dichgans, Martin

Abstract

Recent genome-wide association studies identified the histone deacetylase 9 (HDAC9) gene region as a major risk locus for large-vessel stroke and coronary artery disease. However, the mechanisms linking variants at this locus to vascular risk are poorly understood. In this study, we investigated the candidacy and directionality of HDAC9 in atherosclerosis and analyzed associations between risk alleles at 7p21.1 and plaque characteristics.

Published
2015
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