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1. Impact of COVID-19 Infection on the Outcome of Patients With Ischemic Stroke

Author

Martí-Fàbregas, Joan, Guisado-Alonso, Daniel, Delgado-Mederos, Raquel, Martínez-Domeño, Alejandro, Prats-Sánchez, Luis, Guasch-Jiménez, Marina, Cardona, Pere, Núñez-Guillén, Ana, Requena, Manuel, Rubiera, Marta, Olivé, Marta, Bustamante, Alejandro, Gomis, Meritxell, Amaro, Sergio, Llull, Laura, Ustrell, Xavier, Castilho de Oliveira, Gislaine, Seró, Laia, Gomez-Choco, Manuel, Mena, Luis, Serena, Joaquín, Bashir Viturro, Saima, Purroy, Francisco, Vicente, Mikel, Rodríguez-Campello, Ana, Ois, Angel, Catena, Esther, Carmen Garcia-Carreira, Maria, Barrachina, Oriol, Palomeras, Ernest, Krupinski, Jerzky, Almeria, Marta, Zaragoza, Josep, Esteve, Patricia, Cocho, Dolores, Moreira, Antia, van Eendenburg, Cecile, Emilio Codas, Javier, Pérez de la Ossa, Natalia, Salvat, Mercè, and Camps-Renom, Pol

Published
2021
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2. Abstract TMP70: Relevance Of Persistent Perfusion Deficits On Clinical Outcome After Sucessful Endovascular Treatment

Author

Valls, Adrian, primary, Puig, Josep, additional, Palomar, Alicia, additional, Laredo, Carlos, additional, Werner, Mariano, additional, Remollo Friedemann, Sebastià, additional, Dorado, Laura, additional, Serena, Joaquin, additional, Munuera, Josep, additional, Perez de la Ossa, Natalia, additional, Gomis, Meritxell, additional, Bustamante, Alejandro, additional, Carbonell, Jaime, additional, Larrañaga, Clara, additional, Castaño, Carlos, additional, Muñoz, Lucía, additional, Palomeras, Ernest, additional, Domenech, Sira, additional, Terceño, Mikel, additional, Davalos, Antoni, additional, Millan, Monica, additional, and Hernandez-Perez, Maria, additional

Published
2023
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3. Abstract WP99: Impact Of Venous Delay Evaluated Before And After Mechanical Thrombectomy On Stroke Outcome

Author

Zangana, Lara, primary, Valls, Adrian, additional, Munuera, Josep, additional, Werner, Mariano, additional, Remollo, Sebastiàn, additional, Dorado, Laura, additional, Serena, Joaquin, additional, Puig, Josep, additional, Perez de la Ossa, Natalia, additional, Gomis, Meritxell, additional, Bustamante, Alejandro, additional, Pina, Belen F., additional, Castaño, Carlos, additional, Muñoz, Lucia, additional, Palomeras, Ernest, additional, Massuet, Anna, additional, Terceño, Mikel, additional, Davalos, Antonio, additional, Millan, Monica, additional, and Hernandez-Perez, Maria, additional

Published
2023
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4. Abstract WP4: Intravenous Thrombolysis And Outcomes In Patients With Large-vessel Stroke Directly Admitted Or Transferred To A Thrombectomy-capable Center

Author

Garcia-Tornel Garcia-Camba, Alvaro, primary, Lozano, Prudencio, additional, Requena, Manuel, additional, Rodriguez-Luna, David, additional, Rodriguez-Villatoro, Noelia, additional, Rubiera, Marta, additional, Muchada, Marian, additional, Olive-Gadea, Marta, additional, Rizzo, Federica, additional, boned, sandra, additional, Ribo, Marc, additional, Molina, Carlos A, additional, Pagola, Jorge, additional, Juega, Jesús, additional, Dorado, Laura, additional, Jimenez-Fabrega, Xavier, additional, Cardona, Pedro, additional, Urra, Xabier, additional, Purroy, Francisco, additional, Terceño, Mikel, additional, Flores, Alan F, additional, Chamorro, Angel, additional, Silva, Yolanda, additional, Ustrell, Xavier, additional, Zaragoza, Jose, additional, Roquer, Jaime, additional, Krupinski, Jerzy, additional, Cocho, Dolores, additional, Palomeras, Ernest, additional, Gomez-Choco, Manuel J, additional, Canovas, David, additional, Martí-Fàbregas, Joan, additional, Mas, Natalia, additional, Fagundez, Olga, additional, Abilleira, Sonia, additional, and Perez de la Ossa, Natalia, additional

Published
2023
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5. Early and Delayed Infarct Growth in Patients Undergoing Mechanical Thrombectomy: A Prospective, Serial MRI Study

Author

Hernández-Pérez, María, primary, Werner, Mariano, additional, Remollo, Sebastián, additional, Martín, Carlota, additional, Cortés, Jordi, additional, Valls, Adrian, additional, Ramos, Anna, additional, Dorado, Laura, additional, Serena, Joaquin, additional, Munuera, Josep, additional, Puig, Josep, additional, Pérez de la Ossa, Natalia, additional, Gomis, Meritxell, additional, Carbonell, Jaime, additional, Castaño, Carlos, additional, Muñoz-Narbona, Lucia, additional, Palomeras, Ernest, additional, Domenech, Sira, additional, Massuet, Anna, additional, Terceño, Mikel, additional, Davalos, Antoni, additional, and Millán, Monica, additional

Published
2023
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6. GRECOS Project (Genotyping Recurrence Risk of Stroke): The Use of Genetics to Predict the Vascular Recurrence After Stroke

Author

Fernández-Cadenas, Israel, Mendióroz, Maite, Giralt, Dolors, Nafria, Cristina, Garcia, Elena, Carrera, Caty, Gallego-Fabrega, Cristina, Domingues-Montanari, Sophie, Delgado, Pilar, Ribó, Marc, Castellanos, Mar, Martínez, Sergi, Freijo, Marimar, Jiménez-Conde, Jordi, Rubiera, Marta, Alvarez-Sabín, José, Molina, Carlos A., Font, Maria Angels, Grau Olivares, Marta, Palomeras, Ernest, Perez de la Ossa, Natalia, Martinez-Zabaleta, Maite, Masjuan, Jaime, Moniche, Francisco, Canovas, David, Piñana, Carlos, Purroy, Francisco, Cocho, Dolores, Navas, Inma, Tejero, Carlos, Aymerich, Nuria, Cullell, Natalia, Muiño, Elena, Serena, Joaquín, Rubio, Francisco, Davalos, Antoni, Roquer, Jaume, Arenillas, Juan Francisco, Martí-Fábregas, Joan, Keene, Keith, Chen, Wei-Min, Worrall, Bradford, Sale, Michele, Arboix, Adrià, Krupinski, Jerzy, and Montaner, Joan

Published
2017
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7. Reasons for Not Performing Mechanical Thrombectomy: A Population-Based Study of Stroke Codes

Author

Guisado-Alonso, Daniel, primary, Martínez-Domeño, Alejandro, additional, Prats-Sánchez, Luis, additional, Delgado-Mederos, Raquel, additional, Camps-Renom, Pol, additional, Abilleira, Sònia, additional, de la Ossa, Natalia Pérez, additional, Ramos-Pachón, Anna, additional, Cardona, Pere, additional, Rodríguez-Campello, Ana, additional, Molina, Carlos A., additional, Rudilosso, Salvatore, additional, Martí-Fàbregas, Joan, additional, Marín, Rebeca, additional, Purroy, Francisco, additional, Serena, Joaquín, additional, Canovas, David, additional, Gómez- Choco, Manuel, additional, Ustrell, Xavier, additional, Zaragoza, Josep, additional, Krupinski, Jerzy, additional, Mas Sala, Natalia, additional, Palomeras, Ernest, additional, Cocho, Dolors, additional, Maria Aragonés, Josep, additional, López, Núria, additional, Sanjurjo, Eduard, additional, Carrión Duch, Dolors, additional, López, Mercè, additional, Almendros Rivas, M.Cruz, additional, Monedero Boado, Jordi, additional, Catena, Esther, additional, Rybyeba, Maria, additional, and Diaz, Gloria, additional

Published
2021
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8. Outcomes of a Contemporary Cohort of 536 Consecutive Patients With Acute Ischemic Stroke Treated With Endovascular Therapy

Author

Abilleira, Sònia, Cardona, Pere, Ribó, Marc, Millán, Mònica, Obach, Víctor, Roquer, Jaume, Cánovas, David, Martí-Fàbregas, Joan, Rubio, Francisco, Álvarez-Sabín, José, Dávalos, Antoni, Chamorro, Ángel, de Miquel, Maria Angeles, Tomasello, Alejandro, Castaño, Carlos, Macho, Juan M., Ribera, Aida, Gallofré, Miquel, Sanahuja, Jordi, Purroy, Francisco, Serena, Joaquín, Castellanos, Mar, Silva, Yolanda, van Eendenburg, Cecile, Pellisé, Anna, Ustrell, Xavier, Marés, Rafael, Baiges, Juanjo, Garcés, Moisés, Saura, Júlia, Soler Insa, Josep Maria, Aragonés, Josep Maria, Otermín, Pilar, Cocho, Dolores, Palomeras, Ernest, Pérez de la Ossa, Natalia, Gomis, Meritxell, López-Cancio, Elena, Dorado, Laura, Aleu, Aitzíber, García-Bermejo, Pablo, Rubiera, Marta, Santamarina, Esteban, Pagola, Jorge, Molina, Carlos, Coscojuela, Pilar, Quesada, Helena, Cano, Lluis, Aja, Lucia, Mora, Paloma, Cervera, Álvaro, Amaro, Sergio, Urra, Xabier, Blasco-Andaluz, Jordi, San Roman, Luis, Delgado-Mederos, Raquel, Dinia, Lavinia, Carrera-Giraldo, David, Rodríguez-Campello, Ana, Ois, Ángel, Cuadrado-Godia, Elisa, Vivas, Elio, del Carmen Garcia, Maria, Estela, Jordi, Perendreu, Joan, Krupinski, Jerzy, Huertas-Folch, Sonia, Nicolás-Herrerias, M. Carme, Gómez-Choco, Manuel, García, Sonia, and Martínez, Raul

Published
2014
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9. Abstract 18: The Role of Vascular Imaging at Primary Stroke Centers in the Drip and Ship Paradigm

Author

Flores, Alan, primary, Seró, Laia, additional, Ustrell, Xavier, additional, Pellisé, Anna, additional, Gomez Choco, Manuel, additional, Viñas, Jaume, additional, Palomeras, Ernest, additional, Krupinski, Jurek, additional, Más, Natalia, additional, Cocho, Dolores, additional, Purroy, Francisco, additional, Zaragoza-brunet, Jose, additional, Cardona, Pedro, additional, Serena, Joaquin, additional, Ribó, Marc, additional, Obach, Victor, additional, Rubiera, Marta, additional, and Perez de la Ossa, Natalia, additional

Published
2021
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10. GRECOS Project (Genotyping Recurrence Risk of Stroke): The Use of Genetics to Predict the Vascular Recurrence After Stroke

Author

Fernandez-Cadenas, Israel, Mendióroz, Maite, Giralt, Dolors, Nafría, Cristina, Garcia, Elena, Carrera, Caty, Gallego-Fabrega, Cristina, Domingues-Montanari, Sophie, Delgado Martínez, María Pilar, Ribo, Marc, Castellanos, Mar, Martínez, Sergi, Freijo, Mari Mar, Jiménez-Conde, Jordi, Rubiera, Marta, Alvarez Sabín, José, Molina, Carlos A., Font, Maria Angels, Grau Olivares, Marta, Palomeras, Ernest, Pérez de la Ossa, Natalia, Martinez Zabaleta, Maite, Masjuan, Jaime, Moniche, Francisco, Cánovas, David, Piñana, Carlos, Purroy, Francisco, Cocho, Dolores, Navas, Inma, Tejero, Carlos, Aymerich, Nuria, Cullell, Natalia, Muiño, Elena, Serena, Joaquín, Rubio, Francisco, Dávalos, Antoni, Roquer González, Jaume, Arenillas, Juan F., Martí Fábregas, Joan, Keene, Keith, Chen, Wei-Min, Worrall, Bradford, Sale, Michele, Arboix, Adrià, Krupinski, Jerzy, Montaner, Joan, GRECOSstudy group, and Universitat Autònoma de Barcelona

Subjects
0301 basic medicine, Male, Risk, Candidate gene, recurrence, Genotype, Polymorphism, Single Nucleotide, Article, Brain Ischemia, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Polymorphism (computer science), Recurrence, Genetics, Medicine, risk factors, Humans, Genetic variability, Genotyping, Stroke, Aged, Advanced and Specialized Nursing, business.industry, Proportional hazards model, Stroke recurrence, Hazard ratio, medicine.disease, Prognosis, stroke, 030104 developmental biology, Scotland, Cardiovascular Diseases, Ischemic Attack, Transient, Spain, Cohort, North America, Female, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery
Abstract

Altres ajuts: This study was funded by Marato TV3, by the Spanish stroke research network (INVICTUS-PLUS) and by Generacion project (PI15/01978) Instituto de Salud Carlos III. Dr Fernández-Cadenas is supported by the Miguel Servet program (CP12/03298), Instituto de Salud Carlos III. Several groups participate in the International Stroke Genetics Consortium and the Spanish Stroke Genetics Consortium. The Hospital del Mar is supported by Spain's Ministry of Health (III FEDER, RD12/0042/0020). Study recruitment and collection of data sets for the VISP trial were supported by a grant (R01 NS34447; PI James Toole) from the National Institute of Neurological Disorders and Stroke (NINDS). Genome-wide association studies genotyping (U01 HG004438l; PI David Valle), funded by the National Human Genome Research Institute and the Genomics and Randomized Trials (GARNET) Network (U01HG00516-03; co-PI Michèle M. Sale and Bradford B. Worrall), and genetic data cleaning was provided by the GARNET Coordinating Center (U01HG005157; PI Bruce S. Weir) Background and Purpose-Vascular recurrence occurs in 11% of patients during the first year after ischemic stroke (IS) or transient ischemic attack (TIA). Clinical scores do not predict the whole vascular recurrence risk, therefore we aimed to find genetic variants associated with recurrence that might improve the clinical predictive mode is in IS. Methods-We analyzed 256 polymorphisms from 115 candidate genes in three patient cohorts comprising 4,482 IS or TIA patients. The discovery cohort was prospectively recruited and included 1,494 patients, 6.2% of them developed a new IS during the first year of follow-up. Replication analysis was performed in 2,988 patients using SNPlex or HumanOmni1-Quad technology. We generated a predictive model using Cox regression (GRECOS score), and generated risk groups using a classification tree method. Results-The analyses revealed that rs1800801 in the MGP gene (HR: 1.33, p= 9×10−03), a gene related to artery calcification, was associated with new IS during the first year of follow-up. This polymorphism was replicated in a Spanish cohort (n=1.305), however it was not significantly associated in a North American cohort (n=1.683). The GRECOS score predicted new IS (p=3.2×10−09) and could classify patients, from low risk of stroke recurrence (1.9%) to high risk (12.6%). Moreover, the addition of genetic risk factors to the GRECOS score improves the prediction compared to previous SPI-II score (p=0.03). Conclusions-The use of genetics could be useful to estimate vascular recurrence risk after IS. Genetic variability in the MGP gene was associated with vascular recurrence in the Spanish population.

Published
2016

11. Abstract 153: Prior Statin Therapy is Not Associated With Cerebral Bleeding-prone Angiopathies in Patients With Ischemic Stroke Who Start Long-term Oral Anticoagulation

Author

Martí-Fàbregas, Joan, primary, Prats-Sánchez, Luis, additional, Camps-Renom, Pol, additional, Marín, Rebeca, additional, Delgado-Mederos, Raquel, additional, Martínez-Domeño, Alejandro, additional, Medrano, Santiago, additional, Merino, Elisa, additional, González de Echavarri, José María, additional, Rodriguez-Campello, Ana, additional, Cocho, Dolores, additional, Casado-Naranjo, Ignacio, additional, Fuentes, Blanca, additional, Gómez-Choco, Manuel, additional, Freijo, Mari Mar, additional, De Felipe, Alicia, additional, Canovas, David, additional, Bravo, Yolanda, additional, Lara, Lidia, additional, Calleja, Ana, additional, Sanahuja, Jordi, additional, Llull, Laura, additional, Hernández, María, additional, Zandio, Beatriz, additional, Lago, Aida, additional, Zedde, Marialuisa, additional, Boix, Amelia, additional, Reverté, Silvia, additional, De Arce-Bordas, Ana María, additional, and Palomeras, Ernest, additional

Published
2017
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12. Abstract WP251: Telestroke 2.0 in Catalonia: More Patients Treated and Secondary Transfers Reduced

Author

Gomis, Meritxell, primary, López-Cancio, Elena, additional, Perez de la Ossa, Natalia, additional, Cardona, Pere, additional, Ribó, Marc, additional, Serena, Joaquin, additional, Purroy, Francisco, additional, Garcés, Moisés, additional, López, Mercè, additional, Soteras, Iñigo, additional, Aragonés, Josep Maria, additional, Cocho, Dolores, additional, Palomeras, Ernest, additional, Villagrasa, David, additional, Puiggrós, Elsa, additional, Catena, Ester, additional, Sanjurjo, Eduard, additional, López Claverol, Núria, additional, Carrión, Dolors, additional, Abilleira, Sònia, additional, and Dávalos, Antoni, additional

Published
2017
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13. Abstract TP19: Charlson Comorbidity Index Predicts Mortality and Functional Outcome in Acute Ischemic Stroke Patients Treated With Mechanical Thrombectomy

Author

Samaniego, Daniela, primary, Hernandez-Perez, Maria, additional, Planas, Anna, additional, Martin, Lorena, additional, Dorado, Laura, additional, Lopez-Cancio, Elena, additional, Gomis, Meritxell, additional, Perez de la Ossa, Natalia, additional, Palomeras, Ernest, additional, Castaño, Carlos, additional, and Davalos, Antoni, additional

Published
2016
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14. Determinants and Trends of the Use of Intravenous Thrombolysis for Minor Stroke: A Population-Based Study, 2016 to 2020.

Author

Font MÀ, García-Sánchez SM, Mengual JJ, Mena L, Avellaneda C, Serena J, Valls-Carbó A, Chamorro Á, Ustrell X, Molina C, Cardona P, Guasch-Jiménez M, Purroy F, Rodríguez-Campello A, Palomeras E, Cocho D, Krupinski J, Cánovas D, García-Alhama J, Zaragoza J, Puiggròs E, Matos N, Aragonès JM, Costa X, Sanjurjo E, Pedroza C, Monedero J, Almendros MC, Rybyeva M, Carrión D, Díaz G, Barceló M, Jiménez-Fàbrega X, Salvat-Plana M, Elosúa R, Pérez de la Ossa N, and Gómez-Choco M

Subjects
Female, Humans, Prospective Studies, Treatment Outcome, Thrombolytic Therapy, Thrombectomy, Fibrinolytic Agents therapeutic use, Brain Ischemia therapy, Stroke drug therapy, Stroke epidemiology, Stroke complications, Ischemic Stroke
Abstract

Background: We analyzed the main factors associated with intravenous thrombolysis (IVT) in patients with minor ischemic stroke., Methods: Data were obtained from a prospective, government-mandated, population-based registry of stroke code patients in Catalonia (6 Comprehensive Stroke Centers, 8 Primary Stroke Centers, and 14 TeleStroke Centers). We selected patients diagnosed with ischemic stroke and National Institutes of Health Stroke Scale (NIHSS) ≤5 at hospital admission from January 2016 to December 2020. We excluded patients with a baseline modified Rankin Scale score of ≥3, absolute contraindication for IVT, unknown stroke onset, or admitted to hospital beyond 4.5 after stroke onset. The main outcome was treatment with IVT. We performed univariable and binary logistic regression analyses to identify the most important factors associated with IVT., Results: We included 2975 code strokes; 1433 (48.2%) received IVT of which 30 (2.1%) had a symptomatic hemorrhagic transformation. Patients treated with IVT as compared to patients who did not receive IVT were more frequently women, had higher NIHSS, arrived earlier to hospital, were admitted to a Comprehensive Stroke Centers, and had large vessel occlusion. After binary logistic regression, NIHSS score 4 to 5 (odds ratio, 40.62 [95% CI, 31.73-57.22]; P <0.001) and large vessel occlusion (odds ratio, 16.39 [95% CI, 7.25-37.04]; P <0.001) were the strongest predictors of IVT. Younger age, female sex, baseline modified Rankin Scale score of 0, earlier arrival to hospital (<120 minutes after stroke onset), and the type of stroke center were also independently associated with IVT. The weight of large vessel occlusion on IVT was higher in patients with lower NIHSS., Conclusions: Minor stroke female patients, with higher NIHSS, arriving earlier to the hospital, presenting with large vessel occlusion and admitted to a Comprehensive Stroke Centers were more likely to receive intravenous thrombolysis.

Published
2022
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