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126 results on '"Brown, Robert A."'

4. Results of the ICTuS 2 Trial (Intravascular Cooling in the Treatment of Stroke 2)

Author

Lyden, Patrick, Hemmen, Thomas, Grotta, James, Rapp, Karen, Ernstrom, Karin, Rzesiewicz, Teresa, Parker, Stephanie, Concha, Mauricio, Hussain, Syed, Agarwal, Sachin, Meyer, Brett, Jurf, Julie, Altafullah, Irfan, Raman, Rema, Hess, Mary Jane, Mullin, Anthony, Jane Hess, Mary, Muranevici, Gabriela, Piantadosi, Bonnie, Jimenez-Maggiora, Gustavo, So, Jia-Shing, Jain, Sonia, Diringer, Michael, Derdeyn, Colin, Stern, Barney, Hamilton, Scott, Dietrich, Dalton, Becker, Kyra, Yenari, Midori, Dirnagl, Ulrich, Wijman, Christine, Chamorro, Ángel, Janis, Scott, Moy, Claudia, Lin, Felice, Song, Shlee, Schlick, Konrad, Khanolkar, Pooja, Edwards, Nancy J, Roldan, Ana, Wilson, Jeanette, Little, Amy, Lewis, Pam, Neil, William, Bruce, Nhu, Guzik, Amy, Sohdi, Ajeet, Herial, Nabeel, Ovbiagele, Bruce, Meyer, Dawn, Modir, Royya, Chavez, Ronelyn, Velazquez, Angela, Mayer, Stephan, Claassen, Jan, Falo, Cristina, Tafreshi, Gilda, Kelly, Nancy, Shell, Erin, Dugan, Guy, Kim, Elizabeth, Tanner, Amy, Michel, Patrik, Eskandari, Ashraf, Oddo, Mauro, Suys, Tamarah, Remillard, Suzette, Cordier, Maria, Brown, Robert, Jasak, Sara, McCullough, Louise, Brautigam, Robert, Alexandrov, Andrei, Sisson, April, Albright, Karen, Broessner, Gregor, Schmutzhard, Erich, Escioglou, Elissanet, Jones, William, Poisson, Sharon, Simpson, Jennifer, Shah, Qaisar, Jonczak, Karin, Bussinger, Patricia, Lewandowski, Christopher, Berry, Shannen, Lundell, AnneMarie, Miller, Joseph B, Cruz-Flores, Salvador, Holzer, Eve, Torretta, Susan, Brown, David, Heim, Laura, and Smith, Carlos

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Stroke, Clinical Trials and Supportive Activities, Lung, Brain Disorders, Clinical Research, Neurosciences, Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Hypothermia, Induced, Male, Middle Aged, Outcome Assessment, Health Care, Single-Blind Method, hypothermia, intention to treat analysis, ischemic stroke, neuroprotection, pneumonia, stroke, therapeutics, Collaborators, Cardiorespiratory Medicine and Haematology, Neurology & Neurosurgery, Clinical sciences, Allied health and rehabilitation science
Abstract

Background and purposeTherapeutic hypothermia is a potent neuroprotectant approved for cerebral protection after neonatal hypoxia-ischemia and cardiac arrest. Therapeutic hypothermia for acute ischemic stroke is safe and feasible in pilot trials. We designed a study protocol to provide safer, faster therapeutic hypothermia in stroke patients.MethodsSafety procedures and 4°C saline infusions for faster cooling were added to the ICTuS trial (Intravascular Cooling in the Treatment of Stroke) protocol. A femoral venous intravascular cooling catheter after intravenous recombinant tissue-type plasminogen activator in eligible patients provided 24 hours cooling followed by a 12-hour rewarm. Serial safety assessments and imaging were performed. The primary end point was 3-month modified Rankin score 0,1.ResultsOf the intended 1600 subjects, 120 were enrolled before the study was stopped. Randomly, 63 were to receive hypothermia plus antishivering treatment and 57 normothermia. Compared with previous studies, cooling rates were improved with a cold saline bolus, without fluid overload. The intention-to-treat primary outcome of 90-day modified Rankin Score 0,1 occurred in 33% hypothermia and 38% normothermia subjects, odds ratio (95% confidence interval) of 0.81 (0.36-1.85). Serious adverse events occurred equally. Mortality was 15.9% hypothermia and 8.8% normothermia subjects, odds ratio (95% confidence interval) of 1.95 (0.56-7.79). Pneumonia occurred in 19% hypothermia versus 10.5% in normothermia subjects, odds ratio (95% confidence interval) of 1.99 (0.63-6.98).ConclusionsIntravascular therapeutic hypothermia was confirmed to be safe and feasible in recombinant tissue-type plasminogen activator-treated acute ischemic stroke patients. Protocol changes designed to reduce pneumonia risk appeared to fail, although the sample is small.Clinical trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01123161.

Published
2016

5. Cerebrovascular Complications Associated With Iatrogenic Fungal Meningitis Following Surgical Procedures in Mexico

Author

Becerril-Gaitan, Andrea, primary, Bindal, Shivani, additional, Parker, Samantha L., additional, Mullarkey, Matthew P., additional, Zeineddine, Hussein A., additional, Chen, Justine M., additional, Choi, Huimahn A., additional, Chen, Peng R., additional, Blackburn, Spiros, additional, Day, Arthur, additional, Torres, Luis F., additional, Brown, Robert J., additional, Bowry, Ritvij, additional, and Chen, Ching-Jen, additional

Published
2023
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6. Genome-Wide Association Study of Intracranial Aneurysm Identifies a New Association on Chromosome 7

Author

Foroud, Tatiana, Lai, Dongbing, Koller, Daniel, Van't Hof, Femke, Kurki, Mitja I, Anderson, Craig S, Brown, Robert D, Connolly, Edward Sander, Eriksson, Johan G, Flaherty, Matthew, Fornage, Myriam, von Und Zu Fraunberg, Mikael, Gaál, Emília I, Laakso, Aki, Hernesniemi, Juha, Huston, John, Jääskeläinen, Juha E, Kiemeney, Lambertus A, Kivisaari, Riku, Kleindorfer, Dawn, Ko, Nerissa, Lehto, Hanna, Mackey, Jason, Meissner, Irene, Moomaw, Charles J, Mosley, Thomas H, Moskala, Marek, Niemelä, Mika, Palotie, Aarno, Pera, Joanna, Rinkel, Gabriel, Ripke, Stephan, Rouleau, Guy, Ruigrok, Ynte, Sauerbeck, Laura, Słowik, Agnieszka, Vermeulen, Sita H, Woo, Daniel, Worrall, Bradford B, and Broderick, Joseph

Subjects
Neurosciences, Human Genome, Stroke, Genetics, Brain Disorders, Biotechnology, Aetiology, 2.1 Biological and endogenous factors, Adult, Aged, Chromosomes, Human, Pair 7, Cohort Studies, Female, Genome-Wide Association Study, Humans, Intracranial Aneurysm, Male, Middle Aged, Polymorphism, Single Nucleotide, Whites, chromosomes, human, pair 7, genome-wide association study, intracranial aneurysm, Familial Intracranial Aneurysm Study Investigators, White People, chromosomes, human, pair 7, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurology & Neurosurgery
Abstract

Background and purposeCommon variants have been identified using genome-wide association studies which contribute to intracranial aneurysms (IA) susceptibility. However, it is clear that the variants identified to date do not account for the estimated genetic contribution to disease risk.MethodsInitial analysis was performed in a discovery sample of 2617 IA cases and 2548 controls of white ancestry. Novel chromosomal regions meeting genome-wide significance were further tested for association in 2 independent replication samples: Dutch (717 cases; 3004 controls) and Finnish (799 cases; 2317 controls). A meta-analysis was performed to combine the results from the 3 studies for key chromosomal regions of interest.ResultsGenome-wide evidence of association was detected in the discovery sample on chromosome 9 (CDKN2BAS; rs10733376: P

Published
2014

7. Genome-Wide Association Study of Intracranial Aneurysms Confirms Role of Anril and SOX17 in Disease Risk

Author

Foroud, Tatiana, Koller, Daniel L, Lai, Dongbing, Sauerbeck, Laura, Anderson, Craig, Ko, Nerissa, Deka, Ranjan, Mosley, Thomas H, Fornage, Myriam, Woo, Daniel, Moomaw, Charles J, Hornung, Richard, Huston, John, Meissner, Irene, BaileyWilson, Joan E, Langefeld, Carl, Rouleau, Guy, Connolly, E Sander, Worrall, Bradford B, Kleindorfer, Dawn, Flaherty, Matthew L, Martini, Sharyl, Mackey, Jason, La Rosa, Felipe De Los Rios, Brown, Robert D, and Broderick, Joseph P

Subjects
Prevention, Human Genome, Clinical Research, Brain Disorders, Genetics, 2.1 Biological and endogenous factors, Aetiology, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Intracranial Aneurysm, Polymorphism, Single Nucleotide, RNA, Long Noncoding, Risk Factors, SOXF Transcription Factors, Smoking, genome-wide association study, intracranial aneurysm, FIA Study Investigators, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurosciences, Neurology & Neurosurgery
Abstract

BackgroundGenomewide association studies have identified novel genetic factors that contribute to intracranial aneurysm (IA) susceptibility. We sought to confirm previously reported loci, to identify novel risk factors, and to evaluate the contribution of these factors to familial and sporadic IA.MethodWe utilized 2 complementary samples, one recruited on the basis of a dense family history of IA (discovery sample 1: 388 IA cases and 397 controls) and the other without regard to family history (discovery sample 2: 1095 IA cases and 1286 controls). Imputation was used to generate a common set of single nucleotide polymorphisms (SNP) across samples, and a logistic regression model was used to test for association in each sample. Results from each sample were then combined in a metaanalysis.ResultsThere was only modest overlap in the association results obtained in the 2 samples. In neither sample did results reach genomewide significance. However, the metaanalysis yielded genomewide significance for SNP on chromosome 9p (CDKN2BAS; rs6475606; P=3.6×10(-8)) and provided further evidence to support the previously reported association of IA with SNP in SOX17 on chromosome 8q (rs1072737; P=8.7×10(-5)). Analyses suggest that the effect of smoking acts multiplicatively with the SNP genotype, and smoking has a greater effect on risk than SNP genotype.ConclusionsIn addition to replicating several previously reported loci, we provide further evidence that the association on chromosome 9p is attributable to variants in CDKN2BAS (also known as ANRIL, an antisense noncoding RNA).

Published
2012

13. Guidelines for the Management of Patients With Unruptured Intracranial Aneurysms: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association

Author

Thompson, B. Gregory, Brown, Robert D., Jr, Amin-Hanjani, Sepideh, Broderick, Joseph P., Cockroft, Kevin M., Connolly, E. Sander, Jr, Duckwiler, Gary R., Harris, Catherine C., Howard, Virginia J., Johnston, S. Claiborne (Clay), Meyers, Philip M., Molyneux, Andrew, Ogilvy, Christopher S., Ringer, Andrew J., and Torner, James

Published
2015
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15. Pathogenic Ischemic Stroke Phenotypes in the NINDS-Stroke Genetics Network

Author

Ay, Hakan, Arsava, Ethem Murat, Andsberg, Gunnar, Benner, Thomas, Brown, Robert D., Jr, Chapman, Sherita N., Cole, John W., Delavaran, Hossein, Dichgans, Martin, Engström, Gunnar, Giralt-Steinhauer, Eva, Grewal, Raji P., Gwinn, Katrina, Jern, Christina, Jimenez-Conde, Jordi, Jood, Katarina, Katsnelson, Michael, Kissela, Brett, Kittner, Steven J., Kleindorfer, Dawn O., Labovitz, Daniel L., Lanfranconi, Silvia, Lee, Jin-Moo, Lehm, Manuel, Lemmens, Robin, Levi, Chris, Li, Linxin, Lindgren, Arne, Markus, Hugh S., McArdle, Patrick F., Melander, Olle, Norrving, Bo, Peddareddygari, Leema Reddy, Pedersén, Annie, Pera, Joanna, Rannikmäe, Kristiina, Rexrode, Kathryn M., Rhodes, David, Rich, Stephen S., Roquer, Jaume, Rosand, Jonathan, Rothwell, Peter M., Rundek, Tatjana, Sacco, Ralph L., Schmidt, Reinhold, Schürks, Markus, Seiler, Stephan, Sharma, Pankaj, Slowik, Agnieszka, Sudlow, Cathie, Thijs, Vincent, Woodfield, Rebecca, Worrall, Bradford B., and Meschia, James F.

Published
2014
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17. Multidisciplinary Consensus on Assessment of Unruptured Intracranial Aneurysms: Proposal of an International Research Group

Author

Etminan, Nima, Beseoglu, Kerim, Barrow, Daniel L., Bederson, Joshua, Brown, Robert D., Jr, Connolly, E. Sander, Jr, Derdeyn, Colin P., Hänggi, Daniel, Hasan, David, Juvela, Seppo, Kasuya, Hidetoshi, Kirkpatrick, Peter J., Knuckey, Neville, Koivisto, Timo, Lanzino, Giuseppe, Lawton, Michael T., LeRoux, Peter, McDougall, Cameron G., Mee, Edward, Mocco, J, Molyneux, Andrew, Morgan, Michael K., Mori, Kentaro, Morita, Akio, Murayama, Yuichi, Nagahiro, Shinji, Pasqualin, Alberto, Raabe, Andreas, Raymond, Jean, Rinkel, Gabriel J.E., Rüfenacht, Daniel, Seifert, Volker, Spears, Julian, Steiger, Hans-Jakob, Steinmetz, Helmuth, Torner, James C., Vajkoczy, Peter, Wanke, Isabel, Wong, George K.C., Wong, John H., and Macdonald, R. Loch

Published
2014
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18. Abstract P564: Hypertriglyceridemia as a Treatment Target in Asymptomatic Carotid Stenosis

Author

Chaturvedi, Seemant, primary, Turan, Tanya N, additional, Voeks, Jenifer H, additional, Goldstein, Jeffrey, additional, Teal, Philip A, additional, Chimowitz, Marc I, additional, Barrett, Kevin M, additional, Demaerschalk, Bart M, additional, Howard, Virginia J, additional, Lazar, Ronald M, additional, Moy, Claudia S, additional, Moore, Wesley S, additional, Roubin, Gary S, additional, Brown, Robert D, additional, Meschia, James F, additional, Lal, Brajesh, additional, Howard, George, additional, and Brott, Thomas, additional

Published
2021
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19. Stroke Genetics Network (SiGN) Study: Design and Rationale for a Genome-Wide Association Study of Ischemic Stroke Subtypes

Author

Meschia, James F., Arnett, Donna K., Ay, Hakan, Brown, Robert D., Jr, Benavente, Oscar R., Cole, John W., de Bakker, Paul I.W., Dichgans, Martin, Doheny, Kimberly F., Fornage, Myriam, Grewal, Raji P., Gwinn, Katrina, Jern, Christina, Conde, Jordi Jimenez, Johnson, Julie A., Jood, Katarina, Laurie, Cathy C., Lee, Jin-Moo, Lindgren, Arne, Markus, Hugh S., McArdle, Patrick F., McClure, Leslie A., Mitchell, Braxton D., Schmidt, Reinhold, Rexrode, Kathryn M., Rich, Stephen S., Rosand, Jonathan, Rothwell, Peter M., Rundek, Tatjana, Sacco, Ralph L., Sharma, Pankaj, Shuldiner, Alan R., Slowik, Agnieszka, Wassertheil-Smoller, Sylvia, Sudlow, Cathie, Thijs, Vincent N.S., Woo, Daniel, Worrall, Bradford B., Wu, Ona, Kittner, Steven J., Anderson, Christopher D., Andren, Kerstin, Andsberg, Gunnar, Arsava, Ethem, Barrett, Kevin M., Benner, Thomas, Bentley, Paul, Bevan, Steven, Biffi, Alessandro, Brenner, David, Chapman, Sherita, Cheng, Yu-Ching, Delavaran, Hossein, Deline, Christopher, Dziedzic, Tomasz, Gamble, Dale, Giralt, Eva, Grazer, Anja, Gschwendtner, Andreas, Hegge, Caityln, Heitsch, Laura, Helenius, Johanna, Holmegaard, Lukas, Huq, Mohammed, Irie, Robert E., Jackson, Rebecca, Katschnig, Petra, Katsnelson, Michael, Khoury, Naim, Kilinc, Selma, Kumar, Gyanendra, Labovitz, Daniel, Lanfranconi, Silvia, Langefeld, Carl D., Lemmens, Robin, Li, Linxin, Malik, Shaneela, Melander, Olle, Nordstrom, Sara, Norrving, Bo, Ois, Angel, Ossi, Raid, Peddareddygari, Leema Reddy, Pedersén, Annie, Pera, Joanna, Pucek, Mateusz, Rannikmae, Kristiina, Redfors, Petra, Rhodes, J. David, Ribasés, Marta, Saraf, Neha, Schuerks, Markus, Seiler, Stephan, Sheikh, Huma, Southerland, Andrew M, Sparks, Mary J., Stoegerer, Eva, Sunyer, Jordi, Temple, Ella, Valenti, Raffaella, Weir, David, Weissman, Darren, Woodfield, Rebecca, and Yiin, Gabriel S.C

Published
2013
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22. Familial Intracranial Aneurysms: Is Anatomic Vulnerability Heritable?

Author

Mackey, Jason, Brown, Robert D., Jr, Moomaw, Charles J., Hornung, Richard, Sauerbeck, Laura, Woo, Daniel, Foroud, Tatiana, Gandhi, Dheeraj, Kleindorfer, Dawn, Flaherty, Matthew L., Meissner, Irene, Anderson, Craig, Rouleau, Guy, Connolly, E. Sander, Deka, Ranjan, Koller, Daniel L., Abruzzo, Todd, Huston, John, III, and Broderick, Joseph P.

Published
2013
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23. Are Myocardial Infarction–Associated Single-Nucleotide Polymorphisms Associated With Ischemic Stroke?

Author

Cheng, Yu-Ching, Anderson, Christopher D., Bione, Silvia, Keene, Keith, Maguire, Jane M., Nalls, Michael, Rasheed, Asif, Zeginigg, Marion, Attia, John, Baker, Ross, Barlera, Simona, Biffi, Alessandro, Bookman, Ebony, Brott, Thomas G., Brown, Robert D., Jr, Chen, Fang, Chen, Wei-Min, Ciusani, Emilio, Cole, John W., Cortellini, Lynelle, Danesh, John, Doheny, Kimberly, Ferrucci, Luigi, Grazia Franzosi, Maria, Frossard, Philippe, Furie, Karen L., Golledge, Jonathan, Hankey, Graeme J., Hernandez, Dena, Holliday, Elizabeth G., Hsu, Fang-Chi, Jannes, Jim, Kamal, Ayeesha, Khan, Muhammad Saleem, Kittner, Steven J., Koblar, Simon A., Lewis, Martin, Lincz, Lisa, Lisa, Antonella, Matarin, Mar, Moscato, Pablo, Mychaleckyj, Josyf C., Parati, Eugenio A., Parolo, Silvia, Pugh, Elizabeth, Rost, Natalia S., Schallert, Michael, Schmidt, Helena, Scott, Rodney J., Sturm, Jonathan W., Yadav, Sunaina, Zaidi, Moazzam, Boncoraglio, Giorgio B., Levi, Christopher Royce, Meschia, James F., Rosand, Jonathan, Sale, Michele, Saleheen, Danish, Schmidt, Reinhold, Sharma, Pankaj, Worrall, Bradford, and Mitchell, Braxton D.

Published
2012
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29. Abstract TP131: Carotid Stenosis and Polyvascular Disease

Author

Chaturvedi, Seemant, primary, Meschia, James F, additional, Lal, Brajesh K, additional, Howard, George, additional, Roubin, Gary S, additional, Turan, Tanya N, additional, Teal, Philip, additional, Brown, Robert D, additional, Barrett, Kevin M, additional, Chimowitz, Marc I, additional, Demaerschalk, Bart M, additional, Howard, Virginia J, additional, Huston, John, additional, Lazar, Ronald M, additional, Moore, Wesley S, additional, Moy, Claudia S, additional, Voeks, Jenifer H, additional, and Brott, Thomas G, additional

Published
2020
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30. Abstract TP123: Baseline Differences in Risk Factor Control Between CREST-2 and SAMMPRIS

Author

Turan, Tanya N, primary, Voeks, Jenifer H, additional, Barrett, Kevin M, additional, Brown, Robert D, additional, Chaturvedi, Seemant, additional, Chimowitz, Marc, additional, Demaerschalk, Bart, additional, Emmady, Prabhu, additional, Howard, George, additional, Howard, Virginia J, additional, Huston, John, additional, Jones, Michael, additional, Lal, Brajesh K, additional, Lazar, Ronald M, additional, Moore, Wesley, additional, Moy, Claudia S, additional, Roldan, Ana M, additional, Roubin, Gary S, additional, Sangha, Navdeep, additional, Brott, Thomas G, additional, and Meschia, James F, additional

Published
2020
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31. The Relationship Between Smoking and Replicated Sequence Variants on Chromosomes 8 and 9 With Familial Intracranial Aneurysm

Author

Deka, Ranjan, Koller, Daniel L., Lai, Dongbing, Indugula, Subba Rao, Sun, Guangyun, Woo, Daniel, Sauerbeck, Laura, Moomaw, Charles J., Hornung, Richard, Connolly, E. Sander, Anderson, Craig, Rouleau, Guy, Meissner, Irene, Bailey-Wilson, Joan E., Huston, John, III, Brown, Robert D., Kleindorfer, Dawn O., Flaherty, Matthew L., Langefeld, Carl D., Foroud, Tatiana, and Broderick, Joseph P.

Published
2010
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32. Candidate Gene Polymorphisms for Ischemic Stroke

Author

Matarin, Mar, Brown, W Mark, Dena, Hernandez, Britton, Angela, De Vrieze, Fabienne Wavrant, Brott, Thomas G., Brown, Robert D., Jr, Worrall, Bradford B., Case, L Douglas, Chanock, Stephen J., Metter, E Jeffrey, Ferrucci, Luigi, Gamble, Dale, Hardy, John A., Rich, Stephen S., Singleton, Andrew, and Meschia, James F.

Published
2009
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45. Abstract 104: Topographic White Matter Hyperintensity Patterns Associated With Alzheimer Pathologies

Author

Graff-Radford, Jonathan, primary, de Arenaza-Urquijo, Eider, additional, Schwarz, Christopher, additional, Brown, Robert D, additional, Ward, Chadwick P, additional, Mielke, Michelle M, additional, Przybelski, Scott, additional, Rabinstein, Alejandro A, additional, Lenick, Timothy G, additional, Gunter, Jeffrey L, additional, Petersen, Ronald C, additional, Kantarci, Kejal, additional, Knopman, David S, additional, Lowe, Val, additional, Jack, Clifford, additional, and Vemuri, Prashanthi, additional

Published
2019
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46. Abstract TP527: Baseline Physical Activity Profiles in CREST-2 Trial Participants

Author

Chaturvedi, Seemant, primary, Turan, Tanya, additional, Gordon, Neil F, additional, Voeks, Jenifer H, additional, Chimowitz, Marc I, additional, Howard, Virginia J, additional, Howard, George, additional, Barrett, Kevin M, additional, Brown, Robert D, additional, Lazar, Ronald, additional, Moore, Wesley S, additional, Moy, Claudia S, additional, Roubin, Gary S, additional, Demaerschalk, Bart M, additional, Foster, Malcolm, additional, Wechsler, Lawrence, additional, Lal, Brajesh K, additional, Meschia, James F, additional, and Brott, Thomas G, additional

Published
2019
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47. Abstract WP451: Frequency and Characteristics of Intracerebral Hemorrhage in a Population-based Study

Author

Arnold Fiebelkorn, Catherine, primary, Aakre, Jeremiah, additional, Rabinstein, Alejandro, additional, Flemming, Kelly, additional, Brown, Robert D., additional, Mielke, Michelle, additional, Knopman, David, additional, Petersen, Ronald, additional, Vemuri, Prashanthi, additional, Jack, Clifford, additional, Lower, Val, additional, Kantarci, Kejal, additional, and Graff-Radford, Jonathan, additional

Published
2019
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