1. [Biochemical and ultrastructural changes in the periodontium during the chronic administration of pro-oxidant xenobiotics].
- Author
-
Bobyrev VN, Kovalev EV, Rozkolupa NV, Eremina NF, and Voskresenskiĭ ON
- Subjects
- Animals, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Chloroquine administration & dosage, Chloroquine pharmacology, Free Radicals metabolism, Lipid Peroxidation drug effects, Male, Microscopy, Electron, Periodontium metabolism, Periodontium ultrastructure, Phenytoin pharmacology, Rats, Rats, Wistar, Time Factors, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Chloroquine analogs & derivatives, Periodontium drug effects, Phenytoin administration & dosage
- Abstract
Effects of chronic administration of xenobiotics pro-oxidants on the state of periodontal tissues, level of free-radical oxidation of lipids, and antioxidant provision were studied. Diphenin and delagil were found to promote biochemical and morphological changes similar to the manifestations observed in periodontitis. A conclusion is made about an important role of nonenzymatic free-radical oxidation of lipids and biopolymers in the pathogenesis of periodontitis. The principal stages of contribution of autooxidation to the parodontogenesis are presented.
- Published
- 1994