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The COVID-19 disease spreads swiftly, and nearly three months after the first positive case was confirmed in China, Coronavirus started to spread all over the United States. Some states and counties reported high number of positive cases and deaths, while some reported lower COVID-19 related cases and death. In this paper, the factors that could affect the risk of COVID-19 infection and death were analyzed in county level. An innovative method by using K-means clustering and several classification models is utilized to determine the most critical factors. Results showed that longitudinal coordinate and population density, latitudinal coordinate, percentage of non-white people, percentage of uninsured people, percent of people below poverty , percentage of Elderly people, number of ICU beds per 10,000 people, percentage of smokers were the most significant attributes., Competing Interests: Conflict of interestThe authors declare that they have no conflict of interest., (© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2021.)