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Your search keyword '"Ngampong Kongkathip"' showing total 3 results
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3 results on '"Ngampong Kongkathip"'

1. Further study on synthesis and evaluation of 3,16,20-polyoxygenated steroids of marine origin and their analogs as potent cytotoxic agents

Author

Potjamarn Bunyathaworn, Suthinee Boonananwong, Ngampong Kongkathip, and Boonsong Kongkathip

Subjects
Double bond, Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, Biochemistry, Steroid, chemistry.chemical_compound, Endocrinology, Biosynthesis, Cell Line, Tumor, medicine, Side chain, Animals, Humans, Seawater, Cytotoxicity, Nuclear Magnetic Resonance, Biomolecular, Molecular Biology, Pharmacology, chemistry.chemical_classification, Molecular Structure, Cytotoxins, Cholesterol, Organic Chemistry, Cancer, Biological activity, medicine.disease, chemistry, Steroids, Drug Screening Assays, Antitumor
Abstract

A series of new polyoxygenated steroid derivatives with various steroid skeleton moieties were synthesized. Antitumor activity of the compounds against three tumor cell lines (Breast cancer MCF7, lung cancer NCI and oral cancer KB) were evaluated. Compounds with aromatic A ring of this series exhibited the most potent cytotoxicities in all tested cells. The absence of OH at C-16 or lack of cholesterol like side chain at C-20 in the steroid skeleton apparently result in decreased cytotoxicity. The compound became inactive when the side chain contains double bond at C-24-C-25. When hydroxyl group at C-3 was protected no cytotoxicities against MCF7 and NCI and considerable low cytotoxicity against KB cell lines were observed.

Published
2010
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2. First synthesis of 3,16,20-polyoxygenated cholestanes, new cytotoxic steroids from the gorgonian Leptogorgia sarmentosa

Author

Boonsong Kongkathip, Ngampong Kongkathip, and Suthinee Boonananwong

Subjects
Lung Neoplasms, Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, Leptogorgia sarmentosa, ved/biology.organism_classification_rank.species, Drug Evaluation, Preclinical, Antineoplastic Agents, Breast Neoplasms, Adenocarcinoma, Pharmacology, Biochemistry, Steroid, Cnidaria, Inhibitory Concentration 50, chemistry.chemical_compound, Endocrinology, Cholestanes, Biosynthesis, Cell Line, Tumor, medicine, Animals, Humans, Cytotoxic T cell, Carcinoma, Small Cell, Molecular Biology, Molecular Structure, biology, Cytotoxins, ved/biology, Organic Chemistry, Cancer, Biological activity, biology.organism_classification, medicine.disease, Gorgonian, chemistry, Carcinoma, Squamous Cell, Mouth Neoplasms, Steroids
Abstract

Using tigogenin as starting material, (20 S )-20-hydroxycholestane-3,6-dione ( 1 ), (16 S , 20 S )-16,20-dihydroxycholestan-3-one ( 2 ), (20 S )-20-hydroxycholest-1-ene-3,16-dione ( 3 ) and (20 S )-20-hydroxycholest-4-ene-3,16-dione ( 4 ), natural polyoxygenated steroids from the gorgonian, Leptogorgia sarmentosa , were synthesized in four steps. Antitumor activity against three tumor cell lines (breast cancer, MCF7, lung cancer NCI and oral cancer KB) was evaluated. Two compounds ( 3 and 4 ) showed strong activity against NCI (IC 50 6.16 and 10.51 μM) and moderate activity against MCF7 and KB, the IC 50 being in the range 30.65–47.22 μM. Compound 2 showed moderate activity against NCI (IC 50 42.68 μM) but was inactive against MCF7 and KB whereas compound 1 showed no activity against all tested cells.

Published
2008
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3. Synthesis of cytotoxic novel 9,11-secosterol analogs: Structure/activity studies

Author

Suthinee Boonananwong, Boonsong Kongkathip, Anuch Hasakunpaisarn, and Ngampong Kongkathip

Subjects
Ketone, Stereochemistry, Clinical Biochemistry, Antineoplastic Agents, Biochemistry, HeLa, Inhibitory Concentration 50, Structure-Activity Relationship, Endocrinology, Cell Line, Tumor, Side chain, Structure–activity relationship, Humans, Spiro Compounds, Cytotoxicity, Furans, Molecular Biology, Pharmacology, chemistry.chemical_classification, biology, Chemistry, Organic Chemistry, Biological activity, biology.organism_classification, Sterols, Cholesterol, Cell culture, Function (biology)
Abstract

In an effort to determine the pharmaceutical utility and the structural requirements for activity against tumor cell lines, 30 novel 9,11-secosterol analogues with different side chains and degrees of oxidation at C-9 were synthesized starting from hecogenin. Evaluation of the synthesized compounds for cytotoxicity against KB, HeLa and MCF-7 cell lines revealed that some important structural features are required for activity. The presence of a cholesterol-type side chain, which appears to play a major role in determining the biological activity, the existence of a ketone functional at C-9 is also crucial for anticancer activity whereas hydroxyl/ketone function at C-22 on the side chain did not increase cytotoxicity.

Published
2010

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