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Start Over Author "Velasco, Francisco" Journal stereotactic and functional neurosurgery
22 results on '"Velasco, Francisco"'

21. Electrical Stimulation of Subiculum for the Treatment of Refractory Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis: A 2-Year Follow-Up Study.

Author

Vázquez-Barrón D, Cuéllar-Herrera M, Velasco F, and Velasco AL

Subjects
Adolescent, Adult, Animals, Female, Follow-Up Studies, Humans, Male, Prospective Studies, Rats, Sclerosis, Treatment Outcome, Young Adult, Deep Brain Stimulation methods, Drug Resistant Epilepsy diagnostic imaging, Drug Resistant Epilepsy therapy, Epilepsy, Temporal Lobe diagnostic imaging, Epilepsy, Temporal Lobe therapy, Hippocampus diagnostic imaging
Abstract

Introduction: Evidence has been provided that the subiculum may play an important role in the generation of seizures. Electrical stimulation at this target has been reported to have anticonvulsive effects in kindling and pilocarpine rat models, while in a clinical study of hippocampal deep brain stimulation (DBS), contacts closest to the subiculum were associated with a better anticonvulsive effect., Objectives: To evaluate the effect of electrical stimulation of the subiculum in patients with refractory mesial temporal lobe epilepsy (MTLE) who have hippocampal sclerosis (HS)., Methods: Six patients with refractory MTLE and HS, who had focal impaired awareness seizures (FIAS) and focal to bilateral tonic-clonic seizures (FBTCS), had DBS electrodes implanted in the subiculum. During the first month after implantation, all patients were OFF stimulation, then they all completed an open-label follow-up of 24 months ON stimulation. DBS parameters were set at 3 V, 450 µs, 130 Hz, cycling stimulation 1 min ON, 4 min OFF., Results: There was a mean reduction of 49.16% (±SD 41.65) in total seizure number (FIAS + FBTCS) and a mean reduction of 67.93% (±SD 33.33) in FBTCS at 24 months. FBTCS decreased significantly with respect to baseline, starting from month 2 ON stimulation., Conclusions: Subiculum stimulation is effective for FBTCS reduction in patients with MTLE and HS, suggesting that the subiculum mediates the generalization rather than the genesis of mesial temporal lobe seizures. Better results are observed at longer follow-up times., (© 2020 S. Karger AG, Basel.)

Published
2021
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