1. Apoptotic adipose-derived mesenchymal stem cell therapy protects against lung and kidney injury in sepsis syndrome caused by cecal ligation puncture in rats
- Author
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Kuo-Ho Yeh, Li-Teh Chang, Steve Leu, Yung-Lung Chen, Han-Tan Chai, Sarah Chua, Hong-Hwa Chen, Chic-Chao Yang, Hsueh-Wen Chang, Hon-Kan Yip, Pei-Hsun Sung, Chia-Lo Chang, and Tzu-Hsien Tsai
- Subjects
Male ,medicine.medical_specialty ,Pathology ,Cell- and Tissue-Based Therapy ,Medicine (miscellaneous) ,Apoptosis ,Blood Pressure ,Lung injury ,Kidney ,Mesenchymal Stem Cell Transplantation ,medicine.disease_cause ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,Rats, Sprague-Dawley ,Sepsis ,Leukocyte Count ,Internal medicine ,White blood cell ,medicine ,Animals ,Cecum ,Lung ,Tumor Necrosis Factor-alpha ,business.industry ,Research ,NF-kappa B ,Acute kidney injury ,Kidney metabolism ,Mesenchymal Stem Cells ,Lung Injury ,Cell Biology ,medicine.disease ,Mitochondria ,Rats ,Oxidative Stress ,medicine.anatomical_structure ,Endocrinology ,Adipose Tissue ,Intestinal Perforation ,Creatinine ,Models, Animal ,Molecular Medicine ,business ,Biomarkers ,Oxidative stress - Abstract
Introduction We tested the hypothesis that apoptotic adipose-derived mesenchymal stem cells (A-ADMSC) are superior to healthy (H)-ADMSC in attenuating cecal ligation puncture (CLP)-induced sepsis-mediated lung and kidney injuries. Methods Adult male rats divided into group 1 (sham controls), group 2 (CLP), group 3 [CLP + H-ADMSC administered at 0.5, 6, and 18 hours after CLP], and group 4 [CLP + A-ADMSC administered as in group 3] were sacrificed 72 hours after CLP with blood, lung, and kidney collected for studies. Results White blood cell (WBC) count, circulating TNF-α and creatinine levels were higher in groups 2 and 3 than in groups 1 and 4 (all P
- Published
- 2013