1. Adult myeloid leukaemia and radon exposure: a Bayesian model for a case-control study with error in covariates
- Author
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Francesco Forastiere, Simona Toti, and Annibale Biggeri
- Subjects
Adult ,Male ,Statistics and Probability ,Epidemiology ,chemistry.chemical_element ,Radon ,Bayesian inference ,Statistics ,Covariate ,Humans ,Medicine ,Bayesian hierarchical modeling ,Aged ,Aged, 80 and over ,business.industry ,Case-control study ,Bayes Theorem ,Environmental Exposure ,Middle Aged ,Missing data ,Italy ,chemistry ,Leukemia, Myeloid ,Case-Control Studies ,Female ,Myeloid leukaemia ,business ,Imputation (genetics) - Abstract
The possible association between radon exposure in dwellings and adult myeloid leukaemia had been explored in an Italian province by a case-control study. A total of 44 cases and 211 controls were selected from death certificates file. No association had been found in the original study (OR = 0.58 for > 185 vs 80 ⩽Bq/cm). Here we reanalyse the data taking into account the measurement error of radon concentration and the presence of missing data. A Bayesian hierarchical model with error in covariates is proposed which allows appropriate imputation of missing values. The general conclusion of no evidence of association with radon does not change, but a negative association is not observed anymore (OR = 0.99 for > 185 vs 80 ⩽Bq/cm). After adjusting for residential house radon and gamma radiation, and for the multilevel data structure, geological features of the soil is associated with adult myeloid leukaemia risk (OR = 2.14, 95 per cent Cr.I. 1.0–5.5). Copyright © 2005 John Wiley & Sons, Ltd.
- Published
- 2005