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2. Reversible Antibiotics Loading and pH-Responsive Release from Polymer Brushes on Contact Lens for Therapy and Prevention of Corneal Infections

Author

Wenya Jiang, Jia Qu, Shuaiyue Pang, Hao Chen, Yingying Jin, Yishun Guo, Ai-Wu Fang, Yuqin Wang, and Bailiang Wang

Subjects
chemistry.chemical_classification, Corneal Infection, genetic structures, medicine.drug_class, Antibiotics, Aminoglycoside, Polymer, eye diseases, Bioavailability, Contact lens, chemistry.chemical_compound, chemistry, In vivo, medicine, Biophysics, Phenylboronic acid
Abstract

Corneal infection is an important cause of corneal damage and vision loss. In this work, aminoglycoside antibiotics were grafted onto polymer brushes modified contact lens through dynamic chemical bonds between polyphenol hydroxyls and phenylboronic acid. Both in vitro and in vivo antibacterial tests demonstrated the great promise in prevention of bacterial keratitis which could be attributed to the enhanced the retention time and drug bioavailability.

Published
2020
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