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7. Liposomes Encapsulating Artificial Cytosol as Drug Delivery System

Author

Xunan Zhang, Yunhe Chai, Shuang Han, Hongtao Chu, Chuntao Zhu, Xiuwen Wang, Wei Zong, and Xiaotong Shao

Subjects
Sucrose, History, Polymers and Plastics, Biophysics, Biochemistry, Industrial and Manufacturing Engineering, HeLa, Rhodamine, chemistry.chemical_compound, Cytosol, Drug Delivery Systems, Humans, Business and International Management, Unilamellar Liposomes, Liposome, biology, Chemistry, Sepharose, Vesicle, Organic Chemistry, technology, industry, and agriculture, biology.organism_classification, Doxorubicin, Liposomes, Drug delivery, Agarose, Drug carrier, HeLa Cells
Abstract

The fabrication of cell model containing artificial cytosol is challenging. Herein we constructed an artificial cytosol contained cell model by electroformation method. Agarose was selected as the main component of the artificial cytosol. Sucrose was added into agarose to regulate the sol viscosity and phase transition temperature (Tm). The viscosity of the sol with the mass ratio (agarose-sucrose) 1:9 was closest to the natural cytosolic. DSPC/20 mol% Chol was used to form large unilamellar vesicle (LUV) as cell model compartment. The rhodamine release experiment confirmed that the unique release profile of agarose-sucrose@LUVs suitable as a drug carrier. Doxorubicin (DOX) is loaded in the agarosesucrose@LUVs, and their half maximum inhibition concentration on HeLa cells is 0.016 μmol L−1, which means 28.7 times increase in inhibition efficiency over free DOX.

Published
2021
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8. Synapse Differentiation-Induced Gene 1 Regulates Stress-Induced Depression through Interaction with the AMPA Receptor GluA2 Subunit of Nucleus Accumbens in Mice

Author

Yuanyuan Chen, Yuanyi Zhou, Haoluo Zhang, Xiaojie Wang, Shuang Han, Yaxing Chen, Hui Gu, Yonghai Wang, Rong Chen, Liang Wang, Jiamei Zhang, Qingfan Wei, Huaqin Zhang, Yumam He, Yinglan Zhao, Linhong Jiang, Feng Qin, Yue Zhao, Shu Li, Hongchun Li, Rui Xu, Xiaobo Cen, Xuemei Wan, Qian Bu, Min Li, Haxiaoyu Liu, Shaomin Wang, Yiming Hu, and Yanping Dai

Subjects
Synapse, Chemistry, Protein subunit, Stress induced, AMPA receptor, Nucleus accumbens, Gene, Depression (differential diagnoses), Cell biology
Published
2021
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