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144 results on '"Jie, Chen"'

10. Molecular Insights into the Impacts of Ion Electrophoresis on Stability of Methane Hydrate

Author

JIE CHEN, Zhengcai Zhang, Yongchao Hao, Daniel Porfirio Luis-Jimenez, Jiafang Xu, Nengyou Wu, Fulong Ning, Bin Fang, Jun Zhang, Jianye Sun, Xiluo Hao, Qingguo Meng, Yanlong Li, Yizhao Wan, Chanjuan Liu, and Gaowei Hu

Subjects
History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering
Published
2022

22. CD47KO/CRT Dual-Bioengineered Cell Membrane-Coated Nanovaccine Combined with Anti-PD-L1 Antibody for Boosting Tumor Immunotherapy

Author

Shengyang Liu, Jiayan Wu, Yuanji Feng, Xiaoya Guo, Tong Li, Meng Meng, Jie Chen, Daquan Chen, and Huayu Tian

Subjects
Biomaterials, History, Polymers and Plastics, Biomedical Engineering, Business and International Management, Industrial and Manufacturing Engineering, Biotechnology
Abstract

Tumor vaccines trigger tumor-specific immune responses to prevent or treat tumors by activating the hosts' immune systems, and therefore, these vaccines have potential clinical applications. However, the low immunogenicity of the tumor antigen itself and the low efficiency of the vaccine delivery system hinder the efficacy of tumor vaccines that cannot produce high-efficiency and long-lasting antitumor immune effects. Here, we constructed a nanovaccine by integrating CD47KO/CRT dual-bioengineered B16F10 cancer cell membranes and the unmethylated cytosine-phosphate-guanine (CpG) adjuvant. Hyperbranched PEI25k was used to load unmethylated cytosine-phosphate-guanine (CpG) through electrostatic adsorption to prepare PEI25k/CpG nanoparticles (PEI25k/CpG-NPs). CD47KO/CRT dual-bioengineered cells were obtained by CRISPR-Cas9 gene editing technology, followed by the cell surface translocation of calreticulin (CRT) to induce immunogenic cell death (ICD) in vitro. Finally, the extracted cell membranes were coextruded with PEI25k/CpG-NPs to construct the CD47KO/CRT dual-bioengineered cancer cell membrane-coated nanoparticles (DBE@CCNPs). DBE@CCNPs could promote endocytosis of antigens and adjuvants in murine bone marrow derived dendritic cells (BMDCs) and induce their maturation and antigen cross-presentation. To avoid immune checkpoint molecule-induced T cell dysfunction, the immune checkpoint inhibitor, the anti-PD-L1 antibody, was introduced to boost tumor immunotherapy through a combination with the DBE@CCNPs nanovaccine. This combination therapy strategy can significantly alleviate tumor growth and may open up a potential strategy for clinical tumor immunotherapy.

Published
2022

25. Improved Light and in Vitro Digestive Stability of Lutein-Loaded Nanoparticles Based on Soy Protein Hydrolysates Via Pepsin

Author

Renyi Wu, Xuejiao Qie, Zhaojun Wang, Qiuming Chen, Maomao Zeng, Jie Chen, Fang Qin, and Zhiyong He

Subjects
Health (social science), Plant Science, Health Professions (miscellaneous), Microbiology, lutein, soy protein hydrolysates, encapsulation, nanoparticles, stability, Food Science
Abstract

In order to improve the water solubility and stability of lutein, soy protein isolates (SPI) and their hydrolysates via pepsin (PSPI) and alcalase (ASPI) were used as nanocarriers for lutein to fabricate the lutein-loaded nanoparticles (LNPS) of SPI, PSPI, and ASPI. The encapsulation properties, light, and in vitro digestive stability of lutein in nanoparticles, and protein–lutein interactions were investigated. Compared with SPI-LNPS and ASPI-LNPS, PSPI-LNPS was characterized by uniform morphology (approximately 115 nm) with a lower polydispersity index (approximately 0.11) and higher lutein loading capacity (17.96 μg/mg protein). In addition, PSPI-LNPS presented the higher lutein retention rate after light exposure (85.05%) and simulated digestion (77.73%) than the unencapsulated lutein and SPI-LNPS. Fluorescence spectroscopy revealed that PSPI had stronger hydrophobic interaction with lutein than SPI, which positively correlated with their beneficial effects on the light and digestive stability of lutein. This study demonstrated that PSPI possessed significant potential for lutein delivery.

Published
2022

30. A Durable Zns Cathode for Aqueous Zn-S Batteries

Author

Dongdong Liu, Bin He, Yun Zhong, Jie Chen, Lixia Yuan, Zhen Li, and Yunhui Huang

Subjects
Renewable Energy, Sustainability and the Environment, General Materials Science, Electrical and Electronic Engineering
Published
2022

31. Solving Eigenproblem by Duality Transform

Author

Yu-Jie Chen, Yuan-Yuan Liu, Wen-Du Li, and Wu-Sheng Dai

Subjects
History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering
Published
2022

50. Magnifying Image Enhanced Endoscopy Only Model (MIEEo) Boosted the Diagnostic Efficiency of Early Cancer and Precancerous Lesions in Upper Gastrointestinal Tract：A Multicenter Randomized Controlled Trial

Author

Ai-Rui Jiang, Li-Ming Wen, Jianwei Ding, Rui-Zheng Zou, Xu-Biao Nie, Jing Chen, Wei-Sen Zhang, Liang-Ying Dan, Yu-Xia Zhu, Chun-Mei Ren, Hui Lin, Ying-Yang Wu, Lin-Lin Sheng, Ding-Rong Chen, Guo-Bin Liao, Hai-Yan Zhao, Jian-Jun Li, Ying Zuo, Jie Chen, Shuang Yu, Liang-Bi Xu, and Jianying Bai

Subjects
History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering
Published
2022

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