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1. Polyfunctional analysis of human t cell responses: importance in vaccine immunogenicity and natural infection.

Author

Makedonas, George and Betts, Michael

Subjects
*T cells, *VACCINES, *HIV infections, *VIRUSES, *CELLULAR immunity, *IMMUNOPATHOLOGY
Abstract

The article provides an analysis of human T-cell responses and its role in vaccine immunogenicity and natural infection. HIV vaccine development has been interfered by the inducement of antibodies that can neutralize the virus. Major improvements in the understanding of memory T-cell generation and differentiation has promted the design of vaccines that could induce antigen-specific cellular immunity.

Published
2006
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