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14 results on '"Takaoka, Kunio"'

2. Prognostic Factors for Reduction of Activities of Daily Living Following Osteoporotic Vertebral Fractures

Author

Matsumoto, Tomiya, primary, Hoshino, Masatoshi, additional, Tsujio, Tadao, additional, Terai, Hidetomi, additional, Namikawa, Takashi, additional, Matsumura, Akira, additional, Kato, Minori, additional, Toyoda, Hiromitsu, additional, Suzuki, Akinobu, additional, Takayama, Kazushi, additional, Takaoka, Kunio, additional, and Nakamura, Hiroaki, additional

Published
2012
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3. Characteristic Radiographic or Magnetic Resonance Images of Fresh Osteoporotic Vertebral Fractures Predicting Potential Risk for Nonunion

Author

Tsujio, Tadao, primary, Nakamura, Hiroaki, additional, Terai, Hidetomi, additional, Hoshino, Masatoshi, additional, Namikawa, Takashi, additional, Matsumura, Akira, additional, Kato, Minori, additional, Suzuki, Akinobu, additional, Takayama, Kazushi, additional, Fukushima, Wakaba, additional, Kondo, Kyoko, additional, Hirota, Yoshio, additional, and Takaoka, Kunio, additional

Published
2011
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6. Experimental Spinal Fusion With Recombinant Human Bone Morphogenetic Protein-2 Delivered by a Synthetic Polymer and β-Tricalcium Phosphate in a Rabbit Model

Author

Namikawa, Takashi, primary, Terai, Hidetomi, additional, Suzuki, Eisuke, additional, Hoshino, Masatoshi, additional, Toyoda, Hiromitsu, additional, Nakamura, Hiroaki, additional, Miyamoto, Shimpei, additional, Takahashi, Naoyuki, additional, Ninomiya, Tadashi, additional, and Takaoka, Kunio, additional

Published
2005
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14. Experimental spinal fusion with recombinant human bone morphogenetic protein-2 delivered by a synthetic polymer and beta-tricalcium phosphate in a rabbit model.

Author

Namikawa T, Terai H, Suzuki E, Hoshino M, Toyoda H, Nakamura H, Miyamoto S, Takahashi N, Ninomiya T, and Takaoka K

Subjects
Animals, Bone Morphogenetic Protein 2, Bone Morphogenetic Proteins administration & dosage, Humans, Lumbar Vertebrae diagnostic imaging, Lumbar Vertebrae drug effects, Lumbar Vertebrae surgery, Rabbits, Radiography, Recombinant Proteins administration & dosage, Transforming Growth Factor beta administration & dosage, Calcium Phosphates administration & dosage, Drug Delivery Systems methods, Models, Animal, Polymers administration & dosage, Spinal Fusion methods
Abstract

Study Design: An experimental animal study to achieve posterolateral intertransverse process spine fusion with recombinant bone morphogenetic protein in combination with a new delivery system., Objective: To evaluate the efficacy of a new synthetic biodegradable bone-inducing material containing recombinant human bone morphogenetic protein-2 (rhBMP-2) as a bone-graft substitute for posterolateral intertransverse process fusion in a rabbit model., Summary of Background Data: rhBMP-2, a powerful bone-inducing cytokine, has been used as a bone graft substitute in combination with animal-derived collagen to achieve spinal fusion in animal models. However, the minimum dose of rhBMP-2 required to obtain solid posterolateral intertransverse process fusion was high on the basis of previous reports (>100 microg in rabbit models). To improve the efficacy, performance of rhBMP-2, and the safety of the delivery system for this protein, a more sophisticated system is required., Methods: To fabricate one implant for one-side L4-L5 intertransverse process fusion, beta-tricalcium phosphate (beta-TCP) powder (300 microg), a polymer gel (PLA-DX-PEG block copolymer; 300 microg) and rhBMP-2 (7.5, 15, or 30 microg) were mixed and manually shaped to resemble a rod. Through a posterolateral approach, two implants were placed on both sides (1 per side) by surgery so as to bridge the transverse processes of adult New Zealand white rabbits (n = 27). In control animals, implants without rhBMP or autogenous cortico-cancellous bone chips from the iliaccrest were placed in a similar location. The lumbar vertebrae were recovered 6 weeks after surgery. The posterolateral fusion was examined by manual palpation, radiography, biomechanical testing, and histology., Results: Rabbits that received 15 or 30 microg of rhBMP-2 showed consistent fusion. However, solid fusion was seen in 2 of 5 rabbits with autografting and rabbits that received 7.5 microg of rhBMP-2. Fusion was not observed in the rabbits that did not receive rhBMP-2., Conclusions: Consistent spinal fusion was obtained by implanting a biodegradable bone-inducing implant composed of beta-TCP, PLA-DX-PEG, and rhBMP-2 within a period of 6 weeks. The rhBMP-2 doses required for the spinal fusion were significantly lower than those reported previously.

Published
2005
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