1. Spontaneous acute and chronic spinal cord injuries in paraplegic dogs: a comparative study of in vivo diffusion tensor imaging
- Author
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Adriano Wang-Leandro, Andrea Tipold, N Alisauskaite, Marc K Hobert, Karl Rohn, Veronika M. Stein, and Peter Dziallas
- Subjects
Male ,030218 nuclear medicine & medical imaging ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,Dogs ,Fractional anisotropy ,medicine ,Effective diffusion coefficient ,Animals ,Dog Diseases ,Prospective Studies ,Spinal cord injury ,Spinal Cord Injuries ,Paraplegia ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,General Medicine ,medicine.disease ,Spinal cord ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Diffusion Tensor Imaging ,Neurology ,Anesthesia ,Acute Disease ,Chronic Disease ,Female ,Neurology (clinical) ,medicine.symptom ,Nuclear medicine ,business ,030217 neurology & neurosurgery ,Diffusion MRI - Abstract
Prospective observational-analytical study. Description of diffusion tensor imaging (DTI) metrics obtained from the spinal cord (SC) of dogs with severe acute or chronic spontaneous, non-experimentally induced spinal cord injury (SCI) and correlation of DTI values with lesion extent of SCI measured in T2-weighted (T2W) magnetic resonance imaging sequences. Hannover, Germany. Forty-seven paraplegic dogs, 32 with acute and 15 with chronic SCI, and 6 disease controls were included. T2W and DTI sequences of the thoracolumbar spinal cord were performed. Values of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were obtained from the epicentre of the lesion and one SC segment cranially and caudally and compared between groups. Pearson’s correlation coefficient was calculated between DTI and T2W metrics. During acute SCI, FA values were increased (P=0.0065) and ADC values were decreased (P=0.0099) at epicentres compared to disease controls. FA values obtained from dogs with chronic SCI were lower (P
- Published
- 2016