1. Low cost flatbed scanner label-free biosensor
- Author
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Ugur Aygun, M. Selim Ünlü, Ayca Yalcin Ozkumur, Elif Seymour, Derin Sevenler, Oguzhan Avci, Hakan Urey, Aygün, Uğur, Ürey, Hakan, Avcı, Oğuzhan, Seymour, Elif, Sevenler, Derin D., Ünlü, M. Selim, Özkumur, Ayça Yalçın, College of Engineering, and Department of Electrical and Electronics Engineering
- Subjects
Scanner ,Computer science ,business.industry ,010401 analytical chemistry ,Nanotechnology ,Substrate (printing) ,010402 general chemistry ,01 natural sciences ,Sample (graphics) ,0104 chemical sciences ,Interferometry ,Microscopy ,Optics ,Radiology ,Protein microarray ,Optical biosensor ,Label-free ,DNA / protein microarray ,Flatbed scanner ,business ,Biosensor ,Computer hardware ,Label free biosensor - Abstract
In this paper, we demonstrate utilization of a commercial flatbed document scanner as a label-free biosensor for high-throughput imaging of DNA and protein microarrays. We implemented an interferometric sensing technique through use of a silicon/oxide layered substrate, and easy to implement hardware modifications such as re-aligning moving parts and inserting a custom made sample plate. With a cost as low as 100USD, powered by a USB cable, and scan speed of 30 seconds for a 4mm x 4 mm area with similar to 10 mu m lateral resolution, the presented system offers a super low cost, easy to use alternative to commercially available label-free systems., NA
- Published
- 2016