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Objectives: The purpose of the study was to estimate the prevalence rate of dementia (PRD) in relation to age, gender, and ApoE-genotype., Methods: The random sample consisted of 465 subjects aged 65 and more. The interview was conducted by means of the Canberra Interview for the Elderly. The genotyping of ApoE has been performed by a combination of the polymerase chain reaction and a gel electrophoresis separation., Results: The overall PRD amounted to 10.1% (95% CI 6.8-13.3%) and was higher among females (12.2%) than among males (4.9%). The gender difference was of borderline statistical significance (OR 2.17; 95% CI 0.97-4.84 adjusted for age, education level). PRD rose significantly with age. In contrast, the possession of one copy of ApoE-epsilon 4-allele was not associated with a higher risk of having dementia (OR 1.48; 95% CI 0.60-3.63 adjusted for age, gender, education level)., Conclusions: These results are consistent with the finding from other authors.

Objectives: Falls among elderly are a well-recognised public health problem. The purpose of the present study was to explore the relation between dementia, number of depressive symptoms, activities of daily living, setting, and risk of falling., Methods: Data for the analysis came from a cross-sectional study about dementia, depression, and disabilities, carried out 1995/96 in Zurich and Geneva. The random sample stratified, by age and gender consisted of 921 subjects aged 65 and more. The interview was conducted by means of the Canberra interview for the Elderly, extended by short questionnaire. The subject was classified as a faller if the subject and/or the informant had reported a fall within the last 12 months prior to the interview. Logistic-regression analysis was used to determine the independent impact of dementia, depressive symptoms, and ADL-score on risk of falling., Results: The stepwise logistic regression analysis has revealed a statistically significant association between dementia (OR 2.14, 95% CI 1.15-3.96), two resp. three depressive symptoms (OR 1.64, 95% CI 1.04-2.60) as well as four or more depressive symptoms (OR 2.64, 95% CI 1.39-5.02) and the risk of falling. There was no statistically significant relationship between studied risk factors and the risk of being one-time faller. However, we found a strong positive association between dementia (OR 3.92, 95% CI 1.75-8.79), four or more depressive symptoms (OR 3.90, 95% CI 1.55-9.83) and the risk of being recurrent faller. Moreover, residents of nursing homes (OR 8.50, 95% CI 2.18-33.22) and elderly aged 85 or more (OR 2.29, 95% CI 1.08-4.87) were under statistically significant higher risk of sustaining recurrent falls., Conclusions: The results of the present study confirm that dementia and depression substantially increase the risk of falling.

Falls are frequent among elderly people, and are a still-underestimated medical problem with respect to causes and consequences. The present epidemiological study describes the experience from a 79-bed nursing home in the city of Zürich, regarding frequency, circumstances and consequences of falls. Over half of residents of the studied nursing home fell at least once during the study period of one year, and one third even suffered 3 or more falls. Dizziness, tripping and slipping were among the reasons given for falling. However, in one third of the cases the person involved was not able to specify the cause of the fall. Every fifth fall to injury or fracture, and every tenth fall to fall-related pain. The fall-related overall morbidity therefore amounted to 35.3%.