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The prevalence of diabetes mellitus has increased over time. Medicinal plants, including Andrographis paniculata (Burm.f) Nees, are recognized for their use to manage hyperglycemia. Nowadays, plenty of papers are published about A. paniculata as an antidiabetic; however, no bibliometric study about the topic exists. This study examines the existing papers about the preclinical trial of A. paniculata as an antidiabetic agent using bibliometric analysis focusing on countries, institutions, publishers, authors, documents, and keywords. Bibliographic information of relevant research and conference articles were obtained from the Scopus database. In total, 97 articles published between 1994 and 2021 were selected, covering 376 authors and 1270 keywords. Data were analyzed bibliometrically using Vosviewer 1.6.16. A total of 97 published papers occurred from 1994 to 2021 were selected. India, Universitas Gadjah Mada (Indonesia), Journal of Ethnopharmacology, and Agung Endro Nugroho (Universitas Gadjah Mada, Indonesia) were the most productive country, institution, publisher, and author, respectively. The analysis of the most influential papers, co-citation network of the most influential papers, bibliographical coupling network based on authors, and keyword co-occurrence network and overlay demonstrated that the abundance and variety of existing papers about preclinical trials of A. paniculata as an antidiabetic were from phytochemistry, pharmacology, and drug formulation. The findings of our analysis have implications for managerial and theoretical aspects on this topic, such as encouraging research collaborations by analyzing the contributions of countries, institutions, publishers, and authors and revealing research gaps (molecular mechanisms, toxicities and side effects, drug formulations, and clinical trials) to accept a phytomedicine as a therapeutic option. [Display omitted] • The abundance of preclinical trials of Andrographis paniculata as antidiabetic. • India, Universitas Gadjah Mada (Indonesia), Journal of Ethnopharmacology, and Agung Endro Nugroho were the most productive country, institution, publisher, and authors, respectively. • Research mapping is needed to determine the expansion of the research fields. • The related fields were phytochemistry, pharmacology, and drug formulation. [ABSTRACT FROM AUTHOR]

• Indonesia has rich biodiversity and ethnic groups applying for traditional medicine as antidiabetic. • Numerous ethnopharmacological surveys were conducted on medicinal plants in Indonesia. • Ethnopharmacological studies of antidiabetic plants have prospects for further development. Indonesia is rich in biodiversity and ethnic groups, including those that use traditional medicine to treat diabetes mellitus (DM). Ethnopharmacological of antidiabetic medicinal plants is still an essential field of study to organize preclinical and clinical trials. This study presents a review of the ethnopharmacology of antidiabetic plants and their scientific information, focusing on highlighting gaps and direction for further studies. Data were obtained from online and offline sources to identify Indonesian medicinal plants used to lower blood glucose. Ethnopharmacological literature was searched from Google Scholar with keywords: ethnobotany AND medicinal plant AND diabetes AND Indonesia; an ancient book (Cabe Puyang Warisan Nenek Moyang), government reports on ethnopharmacological surveys, and BSc/MSc/PhD theses indexed and not indexed internationally. Subsequently, other sections regarding preclinical trials (in vitro and in vivo), phytochemical issues, clinical trials, and toxicological assessments were searched from Scopus with the relevant keywords. A total of 229 medicinal plant species belonging to 70 families and are used to treat DM were listed in this study. Among these plants, Asteraceae and Orthosiphon aristatus (Blume) Miq. were the most dominant plant family and species, respectively. Most of the herbal recipes were from North Sumatera (102 recipes). Leaf and boiling were the most applied plant part and mode of preparation, respectively. Furthermore, the top 10 highly cited antidiabetic medicinal plants from ethnopharmacological data were assessed in the preclinical (in vitro and in vivo), phytochemical issues, clinical trials, and toxicological tests. Pharmacological, phytochemical, clinical, and toxicological studies have been reported; meanwhile, many research opportunities can be explored, especially plants lacking scientific evidence. This study's application is expected to accelerate the drug discovery and development from natural resources to treat DM. Moreover, hopefully, medicinal plants can be one of the solutions to treat DM that is effective, safe, and sustainable. [ABSTRACT FROM AUTHOR]