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The article provides comprehensive analysis of industrial development problems in Rivne region. Territorial disparities of industrial development, as well as their causation, are revealed based on the analysis of the basic production assets. Analyzing foreign trade relations of the region, the author determined the problem of ensuring a competitive industrial production. Also the article deals with the causes and essence of a trend consisting in switching of many enterprises to the tolling scheme. Energy efficiency of industries in the region is investigated as the problem escalating due to raise of energy prices. Relevant indicators are compared with the national and European average. One of the important problems described in the article is the environmental pollution by industrial waste and the negative impacts of extractive industries on the regional natural ecosystems. Among problems described in the article the key one is the increasing pace of deterioration of the basic industrial and production funds and low innovation activity of enterprises. [ABSTRACT FROM AUTHOR]