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This paper explores the effectiveness of cross-border cooperation programmes between Spain and Portugal, focusing on their impact and outcomes in Portuguese regions. Drawing on a comprehensive analysis of the programmes, the study examines the socio-economic dynamics in border regions, including job creation, population trends, and investment patterns. The research employs a mixed-methods approach, combining qualitative and quantitative data analysis. We argue that the cross-border territorial cooperation between Spain and Portugal has played a significant role in fostering regional development and addressing common challenges. While the concerted efforts have shown positive results in terms of economic growth and employment, they have not been sufficient to reverse the regressive demographic trends. Thus, it is essential to strengthen cooperation mechanisms, invest in human capital, and foster innovation so that the two countries can work together to create sustainable and inclusive development across their shared border regions. [ABSTRACT FROM AUTHOR]