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Your search keyword '"Zink, Jeffrey I."' showing total 21 results
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21 results on '"Zink, Jeffrey I."'

1. Intracellular Delivery: Redox‐Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap‐Tops Enhances Efficacy Against Pneumonic Tularemia in Mice (Small 27/2016)

Author

Lee, Bai‐Yu, Li, Zilu, Clemens, Daniel L, Dillon, Barbara Jane, Hwang, Angela A, Zink, Jeffrey I, and Horwitz, Marcus A

Subjects
Medical Biotechnology, Biomedical and Clinical Sciences, Biodefense, Infectious Diseases, Prevention, Emerging Infectious Diseases, Vaccine Related, disulfide snap-top, francisella tularensis, intracellular delivery, mesoporous silica nanoparticle, redox potential, Nanoscience & Nanotechnology
Abstract

The drug trapping and intracellular release mechanism of redox-responsive disulfide snap-top mesoporous silica nanoparticles (MSN-SS-MXF) is depicted by J. I. Zink, M. A. Horwitz and co-workers on page 3690. Mesoporous silica nanoparticles with antibiotic (cyan) trapped within their pores by disulfide snap-tops are avidly ingested by macrophages. The intracellular redox potential reduces the disulfide (yellow) in the stalk (green/blue), releases the caps (orange) and frees drug to kill Francisella tularensis (green). Artwork by Bastian Ruehle.

Published
2016

2. pH‐Responsive Isoniazid‐Loaded Nanoparticles Markedly Improve Tuberculosis Treatment in Mice

Author

Hwang, Angela A, Lee, Bai-Yu, Clemens, Daniel L, Dillon, Barbara Jane, Zink, Jeffrey I, and Horwitz, Marcus A

Subjects
Medical Biotechnology, Biomedical and Clinical Sciences, Biodefense, Nanotechnology, Biotechnology, Emerging Infectious Diseases, Rare Diseases, Tuberculosis, Infectious Diseases, Lung, Orphan Drug, Bioengineering, 5.1 Pharmaceuticals, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, Aldehydes, Animals, CHO Cells, Cricetinae, Cricetulus, Disease Models, Animal, Female, Humans, Hydrogen-Ion Concentration, Isoniazid, Macrophages, Mice, Inbred BALB C, Microbial Viability, Mycobacterium tuberculosis, Nanoparticles, Polyethylene Glycols, Polyethyleneimine, Porosity, Prodrugs, Silicon Dioxide, Spectrophotometry, Ultraviolet, drug delivery, mesoporous silica, mesoporous silica nanoparticles, multifunctional nanoparticles, tuberculosis, Nanoscience & Nanotechnology
Abstract

Tuberculosis is a major global health problem for which improved therapeutics are needed to shorten the course of treatment and combat emergence of drug resistance. Mycobacterium tuberculosis, the etiologic agent of tuberculosis, is an intracellular pathogen of mononuclear phagocytes. As such, it is an ideal pathogen for nanotherapeutics because macrophages avidly ingest nanoparticles even without specific targeting molecules. Hence, a nanoparticle drug delivery system has the potential to target and deliver high concentrations of drug directly into M. tuberculosis-infected cells-greatly enhancing efficacy while avoiding off-target toxicities. Stimulus-responsive mesoporous silica nanoparticles of two different sizes, 100 and 50 nm, are developed as carriers for the major anti-tuberculosis drug isoniazid in a prodrug configuration. The drug is captured by the aldehyde-functionalized nanoparticle via hydrazone bond formation and coated with poly(ethylene imine)-poly(ethylene glycol) (PEI-PEG). The drug is released from the nanoparticles in response to acidic pH at levels that naturally occur within acidified endolysosomes. It is demonstrated that isoniazid-loaded PEI-PEG-coated nanoparticles are avidly ingested by M. tuberculosis-infected human macrophages and kill the intracellular bacteria in a dose-dependent manner. It is further demonstrated in a mouse model of pulmonary tuberculosis that the nanoparticles are well tolerated and much more efficacious than an equivalent amount of free drug.

Published
2015

3. Tuberculosis: pH‐Responsive Isoniazid‐Loaded Nanoparticles Markedly Improve Tuberculosis Treatment in Mice (Small 38/2015)

Author

Hwang, Angela A, Lee, Bai-Yu, Clemens, Daniel L, Dillon, Barbara Jane, Zink, Jeffrey I, and Horwitz, Marcus A

Subjects
Medical Biotechnology, Biomedical and Clinical Sciences, Orphan Drug, Biodefense, Infectious Diseases, Nanotechnology, Emerging Infectious Diseases, Tuberculosis, Bioengineering, Rare Diseases, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, Animals, Hydrogen-Ion Concentration, Isoniazid, Mice, Nanoparticles, drug delivery, mesoporous silica, mesoporous silica nanoparticles, multifunctional nanoparticles, tuberculosis, Nanoscience & Nanotechnology
Abstract

On page 5066, J. I. Zink, M. A. Horwitz, and co-workers use confocal microscopy to demonstrate the avid uptake of RITC-labeled mesoporous silica nanoparticles loaded with the anti-tuberculosis drug isoniazid (shown here in red) by human macrophages (nuclei stained blue with DAPI) infected with GFP-expressing Mycobacterium tuberculosis (shown here in green).

Published
2015

7. Two‐Photon‐Triggered Drug Delivery via Fluorescent Nanovalves

Author

Croissant, Jonas, primary, Chaix, Arnaud, additional, Mongin, Olivier, additional, Wang, Miao, additional, Clément, Sébastien, additional, Raehm, Laurence, additional, Durand, Jean‐Olivier, additional, Hugues, Vincent, additional, Blanchard‐Desce, Mireille, additional, Maynadier, Marie, additional, Gallud, Audrey, additional, Gary‐Bobo, Magali, additional, Garcia, Marcel, additional, Lu, Jie, additional, Tamanoi, Fuyuhiko, additional, Ferris, Daniel P., additional, Tarn, Derrick, additional, and Zink, Jeffrey I., additional

Published
2014
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8. Use of Coated Silver Nanoparticles to Understand the Relationship of Particle Dissolution and Bioavailability to Cell and Lung Toxicological Potential

Author

Wang, Xiang, primary, Ji, Zhaoxia, additional, Chang, Chong Hyun, additional, Zhang, Haiyuan, additional, Wang, Meiying, additional, Liao, Yu-Pei, additional, Lin, Sijie, additional, Meng, Huan, additional, Li, Ruibin, additional, Sun, Bingbing, additional, Winkle, Laura Van, additional, Pinkerton, Kent E., additional, Zink, Jeffrey I., additional, Xia, Tian, additional, and Nel, André E., additional

Published
2013
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9. Involvement of Lysosomal Exocytosis in the Excretion of Mesoporous Silica Nanoparticles and Enhancement of the Drug Delivery Effect by Exocytosis Inhibition

Author

Yanes, Rolando E., primary, Tarn, Derrick, additional, Hwang, Angela A., additional, Ferris, Daniel P., additional, Sherman, Sean P., additional, Thomas, Courtney R., additional, Lu, Jie, additional, Pyle, April D., additional, Zink, Jeffrey I., additional, and Tamanoi, Fuyuhiko, additional

Published
2012
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10. Implementation of a Multidisciplinary Approach to Solve Complex Nano EHS Problems by the UC Center for the Environmental Implications of Nanotechnology

Author

Xia, Tian, primary, Malasarn, Davin, additional, Lin, Sijie, additional, Ji, Zhaoxia, additional, Zhang, Haiyuan, additional, Miller, Robert J., additional, Keller, Arturo A., additional, Nisbet, Roger M., additional, Harthorn, Barbara H., additional, Godwin, Hilary A., additional, Lenihan, Hunter S., additional, Liu, Rong, additional, Gardea-Torresdey, Jorge, additional, Cohen, Yoram, additional, Mädler, Lutz, additional, Holden, Patricia A., additional, Zink, Jeffrey I., additional, and Nel, Andre E., additional

Published
2012
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19. Implementation of a Multidisciplinary Approach to Solve Complex Nano EHS Problems by the UC Center for the Environmental Implications of Nanotechnology.

Author

Xia, Tian, Malasarn, Davin, Lin, Sijie, Ji, Zhaoxia, Zhang, Haiyuan, Miller, Robert J., Keller, Arturo A., Nisbet, Roger M., Harthorn, Barbara H., Godwin, Hilary A., Lenihan, Hunter S., Liu, Rong, Gardea‐Torresdey, Jorge, Cohen, Yoram, Mädler, Lutz, Holden, Patricia A., Zink, Jeffrey I., and Nel, Andre E.

Published
2013
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