3 results on '"Valérie Cochen de Cock"'
Search Results
2. Sleepiness in Idiopathic REM Sleep Behavior Disorder and Parkinson Disease
- Author
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Smaranda Leu-Semenescu, Bastien Herlin, Marie Vidailhet, Dulce Neutel, Isabelle Arnulf, Valérie Cochen De Cock, and Jean-Louis Golmard
- Subjects
Male ,Gerontology ,medicine.medical_specialty ,Time Factors ,Polysomnography ,Sleepiness in Idiopathic RBD and Parkinson Disease ,REM Sleep Behavior Disorder ,Disease ,Gastroenterology ,REM sleep behavior disorder ,Arousal ,Atrophy ,Parkinsonian Disorders ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,Dementia ,Aged ,Retrospective Studies ,Parkinsonism ,Epworth Sleepiness Scale ,Parkinson Disease ,Middle Aged ,Multiple System Atrophy ,medicine.disease ,Concomitant ,Female ,Sleep Stages ,Neurology (clinical) ,Psychology ,Brain Stem ,Follow-Up Studies - Abstract
OBJECTIVE To determine whether patients with idiopathic and symptomatic RBD were sleepier than controls, and if sleepiness in idiopathic RBD predicted earlier conversion to Parkinson disease. METHODS The Epworth Sleepiness Scale (ESS) and its determinants were compared at the time of a video-polysomnography for an RBD diagnosis in patients with idiopathic RBD, in patients with Parkinson disease, and in controls. Whether sleepiness at time of RBD diagnosis predicted an earlier conversion to neurodegenerative diseases was retrospectively analyzed in the followed-up patients. RESULTS The 75 patients with idiopathic RBD were sleepier (ESS: 7.8 ± 4.6) at the time of RBD diagnosis than 74 age- and sex-matched controls (ESS: 5.0 ± 3.6, P < 0.0001). They reached the levels of 114 patients with Parkinson disease (ESS: 8.7 ± 4.8), whether they had (n = 78) or did not have (n = 36) concomitant RBD. The severity of sleepiness in idiopathic RBD correlated with younger age, but not with sleep measures. Among the 69 patients with idiopathic RBD who were followed up for a median 3 years (1-15 years), 16 (23.2%) developed parkinsonism (n = 6), dementia (n = 6), dementia plus parkinsonism (n = 2), and multiple system atrophy (n = 2). An ESS greater than 8 at time of RBD diagnosis predicted a shorter time to phenoconversion to parkinsonism and dementia, from RBD onset, and from RBD diagnosis (when adjusted for age and time between RBD onset and diagnosis). CONCLUSIONS Sleepiness is associated with idiopathic REM sleep behavior disorder and predicts more rapid conversion to parkinsonism and dementia, suggesting it is an early marker of neuronal loss in brainstem arousal systems.
- Published
- 2015
3. REM Sleep Behavior Disorder in Patients With Guadeloupean Parkinsonism, a Tauopathy
- Author
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Valérie Cochen De Cock, Jean-Claude Willer, Isabelle Arnulf, Merle Ruberg, Emmanuel Roze, Stéphane Verhaeghe, Annie Lannuzel, Marie Vidailhet, and J.P. Derenne
- Subjects
Male ,Acetogenins ,Polysomnography ,Rapid eye movement sleep ,Physiology ,REM Sleep Behavior Disorder ,Motor Activity ,REM sleep behavior disorder ,Progressive supranuclear palsy ,Diagnosis, Differential ,Disability Evaluation ,Lactones ,Sleep-Wake Transition Disorders ,Parkinsonian Disorders ,Mesencephalon ,Physiology (medical) ,medicine ,Humans ,Prospective Studies ,Guadeloupe ,Aged ,Neurologic Examination ,Sleep disorder ,medicine.diagnostic_test ,Parkinsonism ,Parkinson Disease ,Middle Aged ,medicine.disease ,Sleep in non-human animals ,eye diseases ,Dreams ,Tauopathies ,Fruit ,Dementia ,Female ,Supranuclear Palsy, Progressive ,Neurology (clinical) ,Tauopathy ,Fatty Alcohols ,Psychology ,Neuroscience - Abstract
To describe sleep characteristics and rapid eye movement (REM) sleep behavior disorder in patients with Guadeloupean atypical parkinsonism (Gd-PSP), a tauopathy resembling progressive supranuclear palsy that mainly affects the midbrain. It is possibly caused by the ingestion of sour sop (corossol), a tropical fruit containing acetogenins, which are mitochondrial poisons.Sleep interview, motor and cognitive tests, and overnight videopolysomnography.Thirty-six age-, sex-, disease-duration- and disability-matched patients with Gd-PSP (n = 9), progressive supranuclear palsy (a tauopathy, n = 9), Parkinson disease (a synucleinopathy, n = 9) and controls (n = 9).Tertiary-care academic hospital.REM sleep behavior disorder was found in 78% patients with Gd-PSP (43% of patients reported having this disorder several years before the onset of parkinsonism), 44% of patients with idiopathic Parkinson disease, 33% of patients with progressive supranuclear palsy, and no controls. The percentage of muscle activity during REM sleep was greater in patients with Gd-PSP than in controls (limb muscle activity, 8.3%+/-8.7% vs 0.1%+/- 0.2%; chin muscle activity, 24.3%+/- 23.7% vs 0.7%+/-2.0%) but similar to that of other patient groups. The latency and percentage of REM sleep were similar in patients with Gd-PSP, patients with Parkinson disease, and controls, whereas patients with progressive supranuclear palsy had delayed and shortened REM sleep.Although Gd-PSP is a tauopathy, most patients experience REM sleep behavior disorder. This suggests that the location of neuronal loss or dysfunction in the midbrain, rather than the protein comprising the histologic lesions (synuclein versus tau aggregation), is responsible for suppressing muscle atonia during REM sleep. Subjects with idiopathic REM sleep behavior disorder should avoid eating sour sop.
- Published
- 2007
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