1. T1rho MR properties of human patellar cartilage: correlation with indentation stiffness and biochemical contents
- Author
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Bae, Won C, Statum, Sheronda, Masuda, Koichi, and Chung, Christine B
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Aging ,Humans ,Cartilage ,Articular ,Patella ,Knee ,Magnetic Resonance Imaging ,Water ,Osteoarthritis ,Glycosaminoglycan ,Biomechanics ,Nuclear Medicine & Medical Imaging ,Clinical sciences - Abstract
ObjectiveCartilage degeneration involves structural, compositional, and biomechanical alterations that may be detected non-invasively using quantitative MRI. The goal of this study was to determine if topographical variation in T1rho values correlates with indentation stiffness and biochemical contents of human patellar cartilage.DesignCadaveric patellae from unilateral knees of 5 donors with moderate degeneration were imaged at 3-Telsa with spiral chopped magnetization preparation T1rho sequence. Indentation testing was performed, followed by biochemical analyses to determine water and sulfated glycosaminoglycan contents. T1rho values were compared to indentation stiffness, using semi-circular regions of interest (ROIs) of varying sizes at each indentation site. ROIs matching the resected tissues were analyzed, and univariate and multivariate regression analyses were performed to compare T1rho values to biochemical contents.ResultsGrossly, superficial degenerative change of the cartilage (i.e., roughened texture and erosion) corresponded with regions of high T1rho values. High T1rho values correlated with low indentation stiffness, and the strength of correlation varied slightly with the ROI size. Spatial variations in T1rho values correlated positively with that of the water content (R2 = 0.10, p
- Published
- 2024