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Objective To investigate the relationships between the levels of serum meteorin-like glial cell differentiation regulator (Metrnl), regulated upon activation, normal T-cell expressed and secreted (RANTES) and type 2 diabetes mellitus (T2DM) complicated with coronary heart disease (CHD) . Methods A total of 240 patients with T2DM who had coronary angiography (T2DM group) were selected and divided into the CHD group of 129 cases and non-CHD group of 111 cases according to the coronary angiography results, and another 64 healthy volunteers with physical examination were selected during the same period (control group) . The clinical data of T2DM patients were collected and serum Metrnl and RANTES levels were measured by enzyme-linked immunosorbent assay. Spearman's correlation coefficient was used to analyze the correlations between serum Metrnl and RANTES levels and Gensini score in T2DM patients, and multifactor Logistic regression was used to analyze the factors influencing T2DM complicated with CHD, and receiver operating characteristic (ROC) curves were used to analyze the predictive value of serum Metrnl and RANTES levels on T2DM complicated with CHD. Results Compared with the control group, serum Metrnl levels decreased and RANTES levels increased in the T2DM group (both P<0. 05). Serum Metrnl levels were lower and RANTES levels were higher in the CHD group than in the non-CHD group (both P<0. 05). Spearman's correlation analysis showed a negative correlation between Gensini score and serum Metrnl level and a positive correlation with RANTES level in T2DM patients (rs = -0.657, 0.683, both P<0.05) . Multi-factor Logistic regression analysis showed that increased body mass index (OR=1.145, 95% CI：1.008 to 1.300), prolonged duration of T2DM (OR=1. 120, 95% CI: 1.038 to 1. 208), elevated LDL cholesterol (OR = 1.959, 95% CI：1.009 to 3.805), elevated glycated hemoglobin A1c (OR = 1.361, 95% CI：1. 079 to 1. 718), and elevated RANTES (OR=1.329, 95% CI：1.057 to 1.671) were independent risk factors for T2DM complicated with CHD; and elevated Metrnl (OR = 0.893, 95% CI：0.867 to 0.919) was an independent protective factor (all P<0.05). ROC curve analysis showed that the area under the curve (AUC) of serum Metrnl and RANTES levels alone and in combination in predicting T2DM complicated with CHD were 0.774, 0.760, and 0.855, respectively, and the AUC of the combination of the two was greater than that of either index alone (all P<0.05). Conclusion The serum Metrnl and RANTES levels are closely related to the degree of coronary artery disease in T2DM patients, and are independent influencing factors for T2DM combined with CHD, which can be used as the predictors of T2DM patients with CHD. [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 分析智齿冠周炎患者的口腔健康相关生活质量(OHQOL)及冠周袋菌群变化.方法 选取智齿冠周炎患者144例(智齿冠周炎组),同期体检健康者144例为空白对照组.采用口腔健康影响程度量表(OHIP-14中文版)评价两组OHQOL;采集两组菌斑,涂片后进行革兰染色,正置高倍显微镜计数细菌数量及G+菌、G-菌、螺旋体所占比例.结果 智齿冠周炎组OHIP-14总分为(18.94±5.04)分,空白对照组为(10.53±7.03)分,二者比较P＜0.01.智齿冠周炎组冠周袋内G+菌所占比例低于空白对照组(P均＜0.01),G-菌、螺旋体所占比例及细菌数量均高于空白对照组(P均＜0.01).结论 智齿冠周炎患者OHQOL降低,冠周袋菌群比例失调. [ABSTRACT FROM AUTHOR]