Search

肠易激综合征（IBS）是一种常见的功能性胃肠道疾病，无器质性病变，其病理生理机制至今仍未完全清 楚。脑肠互动是中枢神经系统与胃肠道之间的双向调节机制，而脑肠互动异常可导致胃肠道感觉,运动和分泌失 常，从而引起IBS发病。脑肠互动与神经-内分泌网络密切相关。神经营养因子（NTFs）是一类由神经所支配组织和 神经胶质细胞分泌的蛋白质分子，是神经-内分泌网络中的重要组成，主要包括神经生长因子（NGF）,脑源性神经营 养因子（BDNF）,神经营养因子 3（NT-3）和神经营养因子 4（NT-4）。其中，NGF,BDNF 与 IBS的发生关系密切，二者 均可通过与相应的特异性受体结合介导脑肠互动异常，从外周介导内脏超敏,参与中枢神经对疼痛增敏以及对精神 心理调节等方面参与 IBS的病理生理过程，两者作用机制有相似之处，但其介导途径又有所不同；而 NT-3,NT-4与 IBS的关系目前研究较少，二者作为有可能参与 IBS发病的 NTFs，其作用途径,作用靶点及作用机制有待于进一步 深入研究。 [ABSTRACT FROM AUTHOR]

目的探讨25G玻璃体切割联合白内障超声乳化手术治疗白内障伴有浅前房患者的疗效。方法选取行白内障手术的伴有浅前房的白内障患者86例100眼,随机分为联合手术组42例50眼、超声乳化组44例50眼。联合手术组行25G玻璃体切割联合白内障超声乳化手术;超声乳化组单纯行白内障超声乳化手术,不进行玻璃体切割。术后随访3个月,比较术前及术后l d、l周及3个月时的最佳矫正视力、眼压,中央角膜厚度;比较术前及术后3个月前房深度及角膜内皮细胞丢失率、术中及术后并发症。结果术后1 d及1周时,联合手术组最佳矫正视力均优于超声乳化组,中央角膜厚度变化小于超声乳化组(P<均0.05)。术后3个月时,联合手术组前房深度大于超声乳化组(P<0.05),角膜内皮细胞丢失率低于超声乳化组(P<0.05)。两组术后均未出现严重并发症。结论 25G玻璃体切割联合白内障超声乳化手术治疗伴有浅前房的白内障患者效果较好,可加深前房,降低超声乳化手术难度。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)