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目的 探讨 Wilson 病 (WD) 患者震颤变异中情绪效应的影响因素。方法 选取以震颤为主的 WD 患者 35例 (WD 组) 及同期健康对照者 28 例 (健康组), 采用视频诱发情绪方式诱发积极、中性和消极情绪, 姿态传感器测 量 WD 患者在不同情绪下的震颤参数, 脑电图仪记录 WD 组和健康组在不同情绪时的频谱功率, 自我评估模型 (SAM) 评估诱发相应情绪的效价和唤醒度评分。以中性状态为参照, 分析 WD 患者在积极和消极状态下震颤参数 变异程度与情绪效价和唤醒度的相关性, 比较不同情绪时 WD 组和健康组脑电图仪在β频段各导联功率值对情绪 效价和唤醒度的影响, 16 个耳极导联的脑电信号分别为 Fp1-A1、Fp2-A2、F7-A1、F8-A2、F3-A1、F4-A2、C3-A1、C4-A2、T3-A1、T4-A2、T5-A1、T6-A2、P3-A1、P4-A2、O1-A1、O2-A2, 1 为左侧, 2 为右侧。比较不同情绪时 WD 组各病 变脑区对震颤参数的影响。结果 消极情绪时, 震颤参数 F-acc 和 F-gyr 大于积极和中性情绪 (P均<0. 05); 震颤参 数 RMS-acc 和 RMS-gyr 在三种情绪时差异均无统计学意义 (P均>0. 05)。积极情绪时, WD 组效价得分高于健康组 (P<0. 05), 唤醒度得分差异无统计学意义 (P>0. 05); 消极情绪时, WD 组效价得分低于健康组 (P<0. 05), 唤醒度得 分大于健康组 (P<0. 05); 中性情绪时, WD 组与健康组效价及唤醒度得分差异均无统计学意义 (P均>0. 05)。消极 情绪时, 震颤参数 F-acc 和 F-gyr 的变异程度与效价呈负相关, 与唤醒度呈正相关 (P均<0. 05)。WD 组中 T5 是积极 情绪效价和唤醒度的影响因素 (P<0. 05); F8 是消极情绪效价和唤醒度的影响因素 (P均<0. 05)。健康组中T3 是积 极情绪效价的影响因素 (P<0. 05), T5 是积极情绪唤醒度的影响因素 (P<0. 05); T6 是消极情绪效价的影响因素 (P< 0. 05)。积极情绪时, 壳核是 F-acc、RMS-acc、RMS-gyr 的影响因素 (P均<0. 05); 中性情绪时, 壳核是 F-acc、RMS-acc、 RMS-gyr 的影响因素 (P均<0. 05); 消极情绪时, 壳核是 F-acc、RMS-acc、RMS-gyr 的影响因素 (P均<0. 05)。结论 消 极情绪导致以震颤为主要运动障碍表现的 WD 患者震颤程度增大, 右侧前额叶及壳核损伤是消极情绪影响震颤变 异的因素。 [ABSTRACT FROM AUTHOR]

SIRT家族(SIRT1-7)是-组烟酰胺腺嘌呤二核苷酸(NAD+ )依赖性的组蛋白去乙酰酶, 可通过不同的途径 及机制参与炎症、代谢、氧化应激及细胞凋亡等许多生物过程, 被认为是心血管疾病的潜在治疗靶点. 铁死亡是近 年来发现的一种新的细胞死亡类型, 其与多种心血管疾病的病理生理过程密切相关. SIRT家族可以通过影响氧化 还原平衡、铁代谢及脂质代谢等途径参与铁死亡的发生, 同时在铁死亡介导的心肌损伤、心力衰竭、心房颤动、动脉 粥样硬化等心血管疾病的发生发展过程中发挥重要作用. 深入研究SIRT家族在铁死亡介导心血管疾病中的作用 机制, 可为心血管疾病靶向药物的研发提供新的思路. [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 探讨血压变异性（BPV) 参数及简易糖尿病肾病风险评分在 2型糖尿病肾病早期筛查中的应用价 值。方法 选取516例2型糖尿病患者，于入组第2天采用ABPM6100型动态血压仪监测24 h血压，测量白昼, 夜间 及24 h的平均血压及血压标准差，计算24 h收缩压变异系数（24 h SBPCV), 24 h舒张压变异系数（24 h DBPCV), 白 昼收缩压变异系数（dSBPCV), 白昼舒张压变异系数（dDBPCV), 夜间收缩压变异系数（nSBPCV), 夜间舒张压变异系 数（nDBPCV). 入组当日使用简易糖尿病肾病风险评分筛查表对患者发生DN的风险进行评分。随访6个月，每月 检测 1次尿白蛋白/肌酐比值（UACR) 及预估肾小球滤过率（eGFR), 判断是否发生 DN。比较合并 DN与未合并 DN 患者的BPV和简易糖尿病肾病风险评分，采用多因素Logistic逐步回归分析血压变异性参数及简易糖尿病肾病风险 评分与 DN 发生的关系，绘制受试者工作特征（ROC) 曲线，计算曲线下面积（AUC), 对比不同指标对 DN 的预测价 值。结果 516例患者中，合并DN 108例，未合并DN 408例。合并DN患者的年龄, 病程, 合并高血压比例均高于未 合并 DN 患者；24 h SBPCV, 24 h DBPCV, nSBPCV, nDBPCV 以及简易糖尿病肾病风险评分均高于未合并 DN 患者 （P<0. 05或<0. 01). 多因素Logistic回归分析显示，较高的nSBPCV, nDBPCV, 24 h SBPCV及简易糖尿病肾病风险评 分是2型糖尿病患者并发DN的独立危险因素（P<0. 05或<0. 01). 最终得到各变量与2型糖尿病并发DN关系的回 归方程：Logit（P) =-6. 522 + 0. 170 × nSBPCV + 0. 076 × nDBPCV + 0. 082 × 24 h SBPCV + 0. 159 × 简易糖尿病肾病 风险评分，并拟合成新的联合预测因子 PRE_1。ROC曲线结果显示，简易糖尿病肾病风险评分具有一定预测价值 （AUC=0. 710), 各指标拟合的联合预测因子PRE_1对DN的预测效能优于各指标单独预测（P均<0. 05). 结论 2型 糖尿病患者nSBPCV, nDBPCV, 24 h SBPCV及简易糖尿病肾病风险评分均与DN发生密切相关，各指标联合检测对 DN早期筛查具有一定的临床价值。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的　观察椎动脉颅内近远段粥样硬化狭窄患者的后循环缺血梗死区域、临床症状及伴发脑动脉狭窄 是否有不同。方法　单侧椎动脉颅内段粥样硬化性狭窄≥５０％的后循环缺血患者１３４例，根据椎动脉颅内段狭窄 部位不同分为近段组和远段组，对比分析两组的后循环缺血梗死区域、临床症状及伴发脑动脉狭窄情况。结果　 近段组７４例、远段组６０例。近段组、远段组多发梗死者分别占６３．０％、３３．３％，两组相比，Ｐ＜０．０５。近段组、远段 组临床表现为头痛者分别占１６．２％、３．３％，临床表现为偏瘫者分别占２１．６％、４０．０％，两组相比，Ｐ均＜０．０５。近 段组、远段组伴发椎基底动脉狭窄者分别占２．７％、２６．７％，两组相比，Ｐ＜０．０１。结果　椎动脉颅内近远段粥样硬 化狭窄患者的后循环缺血区域、临床症状及伴发脑动脉狭窄有不同，椎动脉颅内段近段狭窄患者多发梗死及头痛 较远段狭窄患者多见，而远段狭窄患者伴发基底动脉狭窄及偏瘫较近段狭窄患者多见。 [ABSTRACT FROM AUTHOR]

目的 观察经皮冠状动脉介入术（ＰＣＩ）治疗不稳定型心绞痛（ＵＡ）患者的左心室收缩功能及同步性变化。方法 左前降支梗阻的 ＵＡ 患者３５例（观察组），采用 ＰＣＩ 治疗；另选同期健康体检者２５例作为对照（对照 组）。两组均进行实时三维超声心动图检查，比较两组左心室整体功能参数、节段功能参数及同步性参数。结果 与对照组比较，观察组术前整体收缩末期容积（ｇＥＳＶ）、Ｒ-Ｒ间期校正的左心室１６节段达到最小容积时间的标准差 （Ｔｍｓｖ１６-ＳＤ％）增加，整体射血分数（ｇＥＦ）、峰值射血率（ＰＥＲ）／左心室整体舒张末期容积（ｇＥＤＶ）减小；与术前比 较，观察组术后ｇＥＳＶ、Ｔｍｓｖ１６-ＳＤ％减小，ｇＥＦ、ＰＥＲ／ｇＥＤＶ增加。与对照组比较，观察组术前前壁心尖段节段舒张 末期容积（ｒＥＤＶ）增加；与对照组比较，观察组术后前壁心尖段ｒＥＤＶ减小。与对照组比较，观察组术前左前降支供血节段（除前间隔基底段外）的节段收缩末期容积（ｒＥＳＶ）增加；与术前比较，观察组术后左前降支供血节段（除前间隔基底段外）ｒＥＳＶ减小。与对照组比较，观察组术前左前降支供血节段（除前间隔基底段外）节段射血分数 （ｒＥＦ）减小；与术前比较，观察组术后左前降支供血节段（除前间隔基底段外）ｒＥＦ增加。Ｐ均＜０．０５。结论 ＵＡ 患者 ＰＣＩ术前左心室收缩功能及同步性均降低，术后左心室整体收缩功能及节段收缩功能增强，左心室收缩同步性得到改善。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的：分析颅内段与颅外段双侧椎动脉狭窄患者危险因素、后循环缺血表现、梗死区域及预后的差异。方法收集双侧椎动脉狭窄≥50％或闭塞的住院患者129例，根据椎动脉病变部位分为颅内组44例、颅外组85例，依据后循环缺血表现分为无症状、TIA、TIA 后卒中、卒中，梗死部位分为近端、中部、远端、多发性梗死，采用出院改良 Rankin（mRS）评分评价预后，比较颅内组和颅外组脑血管病危险因素、缺血表现、梗死区域、mRS 评分的差异。结果颅内组年龄低于颅外组，高血压患者比例高于颅外组（P 均＜0．05），两组缺血临床表现构成比、梗死区域构成比差异有统计学意义（P 均＜0．05），两组 mRS 评分比较差异无统计学意义（P ＞0．05）。结论颅内段双侧椎动脉狭窄患者年龄低于颅外段，且易并发高血压，颅内段与颅外段双侧推动脉狭窄的后循环缺血表现和梗死区不同，二者预后无显著差别。 [ABSTRACT FROM AUTHOR]