Objective To analyze the potential targets of self-designed Zhongfeng 1 prescription in treatment of cere⁃ bral hemorrhage，and to analyze their biological functions. Methods Firstly，the chemical components and targets of the self-designed Zhongfeng 1 prescription were collected from TCMSP，TCMID and Chemistry Database. The targets of in⁃ tracerebral hemorrhage were obtained from OMIM，DisgenET and GeneCards database. Using R software，the self-de⁃ signed Zhongfeng 1 was interacted with cerebral hemorrhage-related targets to obtain the common targets（potential thera⁃ peutic target). The obtained common targets were screened by protein-protein interaction（PPI）on the STRING platform to identify the key targets for the treatment of cerebral hemorrhage. Metascape database and R software were used to ana⁃ lyze the biological functions（GO and KEGG enrichment analysis）of the key targets of the prescription in the treatment of cerebral hemorrhage. Finally，PyMoL and Autodock Vina were used to verify the core chemical components of the prescription with the key targets for molecular docking. Results A total of 53 effective TCM chemical components, and 124 targets for drug action and 1 896 intracerebral hemorrhage-related targets were collected, and 71 potential therapeutic targets of the self-designed Zhongfeng 1 prescription were finally obtained. The key targets screened by PPI included JUN, TP53, AKT1, VEGFA, etc. A total of 1 715 GO items were enriched，and they were mainly involved in the oxidative stress, apoptotic signaling pathway, etc. Totally 130 items were enriched from KEGG pathway，mainly including PI3K-Akt signal⁃ ing pathway，P53 signaling pathway, cAMP signaling pathway，NF-κB signaling pathway，etc. The molecular docking re⁃ sults showed that the core chemical components had strong binding ability to the target. Conclusion The core targets of self-designed Zhongfeng 1 prescription in the treatment of cerebral hemorrhage include Jun, TP53, Akt1, and VEGFA, etc，they inhibit the inflammatory response and apoptosis，reduce oxidative stress；the related signal pathways mainly include PI3K-AKT，P53, cAMP, NF-κB，and other signal pathways. [ABSTRACT FROM AUTHOR]