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Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

心律失常是乌头碱中毒最常见的临床表现之一，重症患者甚至出现恶性心律失常，若不能及时给予有效 的治疗，可导致患者死亡。急性乌头碱中毒致心律失常最常见的治疗方法为药物疗法，阿托品是多种心律失常的基 础性用药，室性心律失常时可用利多卡因、胺碘酮，发生心室电风暴时需应用 β 受体阻滞剂，镁离子制剂、中药制剂 联合上述药物可提高治疗效果，上述药物治疗无效者可以尝试静脉推注脂肪乳。在药物常规治疗的基础上联合血 液净化疗法治疗，可加速乌头碱中毒致心律失常的转归。近年随着技术的不断发展，临时起搏器、体外膜肺氧合技 术越来越多的应用于乌头碱中毒致心律失常患者的治疗，取得较为显著的效果。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the value of detecting serum soluble CD40 ligand (sCD40L) and soluble intracellular adhesion molecule-1 (sICAM-1) in diagnosis of type 2 diabetic nephropathy (DN). Methods Eighty patients with DN (observation group) and 80 patients with simple type 2 diabetes mellitus (control group) were selected. Fasting blood glucose, 2 h postprandial blood glucose, serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), sCD40L, sICAM-1, urinary microalhumin excretion rate (UACR), and glomerular filtration rate (eGFR) were measured. Multivariate logistic regression was used to analyze the risk factors of DN. The diagnostic value of serum sCD40L and sICAM-1 levels for DN was analyzed by ROC. Results The levels of TC, TG, LDL-C, sCD40L, sICAM-1, and UACR in the observation group were higher than those in the control group, and eGFR was lower than that in the control group (all P <0.05). Multivariate logistic regression analysis showed that the duration of diabetes, TC, sCD40L, sICAM-1 and UACR were independent risk factors for DN (all P < 0.05). ROC analysis showed that the sensitivity and specificity of serum sCD40L and sICAM-1 for the diagnosis of DN were above 0.75.The sensitivity and specificity of combined detection of sCD40L and sICAM-1 levels for the diagnosis of DN were 0.860 and 0.848, respectively, which were higher than those of the single detection (all P < 0.05). Conclusion Serum levels of sCD40L and sICAM-1 in DN patients increase significantly, and the combined detection of serum sCD40L and sl-CAM-1 levels in patients with type 2 diabetes mellitus can prompdy detect and diagnose DN. [ABSTRACT FROM AUTHOR]

目的分析慢性肾脏病(CKD)患者血清Klotho、微炎症状态、氧化应激指标与肾功能的关系。方法选取CKD患者97例(2~3期51例、4~5期46例,CKD组)及年龄、性别相匹配的健康体检者40例(对照组),检测两组血清Klotho、微炎症状态[白细胞介素18(IL-18)、超敏C反应蛋白(hs-CRP)、IL-6]、氧化应激指标[丙二醛(MDA)、晚期氧化蛋白产物(AOPP)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)]及肾小球滤过率(e GFR),并分析CKD组血清Klotho、微炎症状态、氧化应激指标与肾功能的关系。结果 CKD组2~3期、4~5期患者血清Klotho、SOD、GSH-Px及e GFR水平均低于对照组(P均<0.05),血清IL-18、hs-CRP、IL-6、MDA、AOPP水平均高于对照组(P均<0.05);CKD组4~5期患者血清Klotho、SOD、GSH-Px及e GFR水平低于2~3期(P均<0.05),血清IL-18、hs-CRP、IL-6、MDA、AOPP水平均高于2~3期(P均<0.05)。CKD组血清Klotho、SOD、GSH-Px与患者e GFR呈正相关(r分别为0.621、0.622、0.553,P均<0.05),血清MDA、AOPP、IL-18、hs-CRP、IL-6与e GFR呈负相关(r分别为-0.416、-0.639、-0.517、-0.556、-0.485,P均<0.05)。结论 CKD患者随着病情分级增加,其血清Klotho、抗氧化指标及肾功能降低,微炎症状态、过氧化指标升高;CKD患者血清微炎症状态、过氧化指标与肾功能呈负相关,血清Klotho、抗氧化指标与肾功能呈正相关。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的　比较固定义齿和活动义齿修复老年牙列缺损患者的临床疗效。方法　选择老年牙列缺损患者 90例，分为观察组、对照组各45例。对照组采用活动义齿修复，观察组采用固定义齿修复。比较治疗2年后两组 义齿修复效果及牙体健康状况。比较两组治疗前及治疗后2年基牙出血指数。结果　对照组、观察组义齿修复的 总有效率分别为77.59％、94.64，观察组总有效率高于对照组(Ｐ<0.05)。对照组、观察组牙体健康有效率分别为 77.78％、93.33％，观察组牙体健康有效率高于对照组(Ｐ<0.05)。治疗前对照组、观察组基牙出血指数分别为 3.52±0.81、3.45±0.87，治疗后分别为1.64±0.88、1.02±0.76，治疗后观察组基牙出血指数低于对照组(Ｐ< 0.05)。结论　与活动义齿相比，固定义齿修复老年牙列缺损患者的远期疗效较好，患者基牙出血少。 [ABSTRACT FROM AUTHOR]