Search

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 探讨 2 型糖尿病 (T2DM) 住院人群与甲状腺功能异常共患发生的危险因素。方法 回顾性分析 285 例 T2DM 患者的临床资料, 根据是否合并甲状腺功能异常发生分为共患组 67 例与非共患组 218 例。比较两组性别、年龄、体质量指数 (BMI)、病程、二甲双胍使用情况及糖尿病并发症等情况, 以及实验室检测指标糖化血红蛋白 (Hb A1c)、空腹血糖 (FPG)、空腹胰岛素 (INS)、尿酸 (UA)、空腹 C 肽 (FCP)、促甲状腺激素释放激素 (TSH)、甲状腺自身抗体、血脂 (TC、TG、LDL-C、HDL-C) 水平, 采用非条件多因素 Logistic 回归分析 T2DM 甲状腺功能异常共患发生的危险因素。结果 与非共患组比较, 共患组女性、年龄≥65 岁、长病程> 5年、BMI≥25 kg/m²、有高胰岛素血症、甲状腺自身抗体阳性、并发症个数多患者比例较高, 二甲双胍使用比例较低, 两组比较差异有统计学意义 (P均<0. 05)。两组 FPG、TC、LDL-C、FCP、INS、TSH 水平比较差异有统计学意义 (P均<0. 05)。多因素 Logistic 回归分析显示, 性别、年龄、病程、BMI、TC、甲状腺自身抗体是糖尿病合并甲状腺功能异常发生的独立危险因素 (P均<0. 05), 二甲双胍是糖尿病合并甲状腺功能异常发生的保护性因素 (P <0. 05)。结论 糖尿病与甲状腺功能异常共患发生率较高; T2DM 患者性别、年龄、糖尿病病程、BMI、并发症及血糖、C-肽、血脂水平均与甲状腺功能异常共患相关; 糖尿病患者给予二甲双胍治疗可减少甲状腺疾病发生。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)