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心力衰竭作为各种心脏疾病的终末阶段,严重威胁公众健康。炎性作用在心血管疾病中发挥重要作用,尤其是炎性生物学标志物在心力衰竭患者中被广泛研究,主要参与心力衰竭的炎症反应及心肌纤维化、细胞凋亡,不仅可评估患者心力衰竭的严重程度,还能预测心力衰竭患者长期心血管事件的发生率及病死率,为心力衰竭的预后风险评估提供依据。近年研究提示,生物学标志物如穿透素3、中性粒细胞与淋巴细胞比值、小分子核糖核酸、脂联素、P2X7嘌呤受体、生长分化因子-15、可溶性ST2、半乳糖凝集素3等均与心力衰竭的发生发展、预后密切相关,对心力衰竭的早期诊断、治疗及预后评估有重要意义。 [ABSTRACT FROM AUTHOR]

目的　观察羟考酮静脉自控镇痛的宫颈癌切除术患者术后镇痛情况及免疫功能。方法　６0 例择期行 腹腔镜下宫颈癌根治术的宫颈癌患者，随机分为观察组和对照组各３0 例。两组均行腹腔镜下宫颈癌根治术。术 后观察组采用羟考酮静脉自控镇痛，对照组采用芬太尼静脉自控镇痛，共治疗２ ｄ。分别于术后１２、２４、４８ ｈ 时采用 视觉模拟疼痛评分（ＶＡＳ）评价两组术后疼痛情况。分别于术前３0 ｍｉｎ、术后２４ ｈ、术后４８ ｈ、术后７２ ｈ 采集两组外 周静脉血４ ｍＬ，采用流式细胞法检测两组外周血ＣＤ３ + 、ＣＤ４ + 、ＣＤ８ + Ｔ 细胞和ＮＫ 细胞百分比；采用ＥＬＩＳＡ 法检测 两组血清干扰素γ（ＩＦＮ-γ）、白细胞介素１0（ＩＬ-１0）。结果　术后１２、２４、４８ ｈ 时观察组ＶＡＳ 评分分别为（３. ５0 ± 0. ５１）、（３. 0７ ±0. ６７）、（２. ９６ ±0. ６２）分，对照组分别为（３. １７ ± 0. ３８）、（２. ９３ ± 0. ５８）、（２. ８0 ± 0. ４８）分，术后１２ ｈ 观察组ＶＡＳ 评分高于对照组，Ｐ ＜0. 0５。术后４８、７２ ｈ 观察组外周血ＣＤ４ + 、ＣＤ８ + Ｔ 细胞百分比高于对照组（Ｐ 均 ＜0. 0５），术后２４、４８、７２ ｈ 观察组外周血ＮＫ 细胞百分比高于对照组（Ｐ 均＜ 0. 0５）。术后４８、７２ ｈ 观察组血清 ＩＦＮ-γ水平低于对照组（Ｐ 均＜0. 0５）。术后２４、４８、７２ ｈ 观察组血清ＩＬ-１0 水平高于对照组（Ｐ 均＜ 0. 0５）。结论　 宫颈癌切除术患者术后羟考酮静脉自控镇痛效果较好。羟考酮静脉自控镇痛可改善患者术后免疫功能，减轻炎症 反应。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)