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21 results on '"Law, Matthew"'

9. Funding antiretroviral treatment for HIV-positive temporary residents in Australia prevents transmission and is inexpensive

Author

Gray, Richard T., primary, Watson, Jo, additional, Cogle, Aaron J., additional, Smith, Don E., additional, Hoy, Jennifer F., additional, Bastian, Lisa A., additional, Finlayson, Robert, additional, Drummond, Fraser M., additional, Whittaker, Bill, additional, Law, Matthew G., additional, and Petoumenos, Kathy, additional

Published
2018
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15. Testing for HIV among men who have sex with men needs a paradigm shift in Australia, given the minimal increase between 2003 and 2013 in Melbourne, Australia

Author

Lin, An-Chieh, primary, Fairley, Christopher K., additional, Dutt, Krishneel, additional, Klassen, Karen M., additional, Chen, Marcus Y., additional, Fehler, Glenda, additional, Law, Matthew, additional, Bradshaw, Catriona S., additional, Denham, Ian, additional, Read, Tim R. H., additional, and Chow, Eric P. F., additional

Published
2015
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17. High rates of sexually transmissible infections in HIV-positive patients in the Australian HIV Observational Database: a prospective cohort study

Author

Mulhall, Brian P., primary, Wright, Stephen, additional, Allen, Debbie, additional, Brown, Katherine, additional, Dickson, Bridget, additional, Grotowski, Miriam, additional, Jackson, Eva, additional, Petoumenos, Kathy, additional, Read, Phillip, additional, Read, Timothy, additional, Russell, Darren, additional, Smith, David J., additional, Templeton, David J., additional, Fairley, Christopher K., additional, and Law, Matthew G., additional

Published
2014
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20. Risk factors and causes of death in the Australian HIV Observational Database

Author

Petoumenos, Kathy, Law, Matthew G., and Database, on behalf of the Australian HIV Observational

Abstract

Introduction: Mortality rates in HIV-infected people remain high in the era of highly active antiretroviral treatment (HAART). The objective of this paper was to examine causes of deaths in the Australian HIV Observational Database (AHOD) and compare risk factors for HIV-related and HIV-unrelated deaths. Methods: Data from AHOD, an observational study of people with HIV attending medical sites between 1999 and 2004, were analysed. Primary and underlying causes of death were ascertained by sites completing a standardised cause of death form. Causes of death were then coded as HIV-related or HIV-unrelated. Risk factors for HIV-related and unrelated deaths were assessed using survival analysis among patients who had a baseline and at least one follow-up CD4 and RNA measure. Results: The AHOD had enrolled 2329 patients between 1999 and 2004. During this time, a total of 105 patients died, with a crude mortality rate of 1.58 per 100 person years. Forty-two (40%) deaths were HIV-related (directly attributable to an AIDS event), 55 (52%) HIV-unrelated (all other causes), and eight had unknown cause of death. Independent risk factors for HIV-related deaths were low CD4 count and receipt of a larger number of antiretroviral treatment combinations. Among HIV-unrelated deaths, low CD4 count and older age were independent risk factors. Conclusions: In AHOD in the HAART era, mortality in people with HIV remains around 10-fold higher than in the general population. In our analyses, HIV-unrelated deaths were associated with more advanced HIV disease in a similar way to HIV-related deaths.

Published
2006
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21. Physical function limitation among gay and bisexual men aged ≥55years with and without HIV: findings from the Australian Positive and Peers Longevity Evaluation Study (APPLES).

Author

Boettiger DC, Huque MH, Bloch M, Woolley I, Templeton DJ, Law MG, Fraser N, Hoy J, and Petoumenos K

Subjects
Humans, Middle Aged, Cross-Sectional Studies, Australia epidemiology, Malus, HIV Infections epidemiology
Abstract

Background: As people living with HIV now have a life expectancy approaching that of the general population, clinical care focuses increasingly on the management and prevention of comorbidities and conditions associated with aging. We aimed to assess the prevalence of physical function (PF) limitation among gay and bisexual men (GBM) and determine whether HIV is associated with severe PF limitation in this population., Methods: We analysed cross-sectional data from GBM aged ≥55years in the Australian Positive and Peers Longevity Evaluation Study who completed a self-administered survey on health and lifestyle factors. PF was measured using the Medical Outcomes Study-Physical Functioning scale. Factors associated with severe PF limitation were assessed using logistic regression., Results: The survey was completed by 381 men: 186 without HIV and 195 with HIV. Median age was 64.3years for GBM without HIV and 62.1years for GBM with HIV. Compared with men without HIV, those with HIV had higher proportions of severe (13.3% vs 8.1%) and moderate-to-severe (26.7% vs 24.2%) PF limitation. Severe PF limitation commonly involved difficulty with vigorous activity (95% with severe PF limitation described being limited a lot), climbing several flights of stairs (68.4% limited a lot), bending, kneeling or stooping (60.5% limited a lot), and walking 1km (55.0% limited a lot). In a model adjusted for age, body mass index, typical duration of physical activity, psychological distress, and number of comorbidities, we found a significant association between HIV and severe PF limitation (adjusted odds ratio 3.3 vs not having HIV, 95% confidence interval 1.3-8.7)., Conclusions: The biological mechanisms underlying this association require further investigation, particularly given the growing age of the HIV population and inevitable increase in the burden of PF limitation.

Published
2022
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