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The psychological research literature on children born with disorders of sex development (DSDs) has largely focused on their psychosexual development, with less attention given to other aspects of their psychosocial well-being, including the presence of clinical range behaviour problems. Children with DSDs may be at risk for behaviour problems for several reasons: (1) the chronic nature of their medical condition; (2) co-morbid medical problems; (3) the need for repeated in-patient hospitalizations and medical evaluations; (4) stigmatization for pervasive cross-gender behaviour (when this is an aspect at the DSD) and (5) family stress related to caring for a child with a chronic medical condition. The present paper will examine behaviour problems of children with DSD and discuss the complex ethical and psychological problems with which medical staff and parents involved in the care of these patients have to cop.