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Amnestic mild cognitive impairment (aMCI) is a transitional stage between normal aging and Alzheimer's disease, making early screening imperative for potential intervention and prevention of progression to Alzheimer's disease (AD). Therefore, there is a demand for research to identify effective and easy-to-use tools for aMCI screening. While behavioral tests in virtual reality environments have successfully captured behavioral features related to instrumental activities of daily living for aMCI screening, further investigations are necessary to establish connections between cognitive decline and neurological changes. Utilizing electroencephalography with steady-state visual evoked potentials, this study delved into the correlation between behavioral features recorded during virtual reality tests and neurological features obtained by measuring neural activity in the dorsal stream. As a result, this multimodal approach achieved an impressive screening accuracy of 98.38%. [ABSTRACT FROM AUTHOR]

Gait disturbance is a common sequela of stroke. Conventional gait analysis has limitations in simultaneously assessing multiple joints. Therefore, we investigated the gait characteristics in stroke patients using hip-knee cyclograms, which have the advantage of simultaneously visualizing the gait kinematics of multiple joints. Stroke patients (n = 47) were categorized into two groups according to stroke severity, and healthy controls (n = 32) were recruited. An inertial measurement unit sensor-based gait analysis system, which requires placing seven sensors on the dorsum of both feet, the shafts of both tibias, the middle of both femurs, and the lower abdomen, was used for the gait analysis. Then, the hip-knee cyclogram parameters (range of motion, perimeter, and area) were obtained from the collected data. The coefficient of variance of the cyclogram parameters was obtained to evaluate gait variability. The cyclogram parameters differed between the stroke patients and healthy controls, and differences according to stroke severity were also observed. The gait variability parameters mainly differed in patients with more severe stroke, and specific visualized gait patterns of stroke patients were obtained through cyclograms. In conclusion, the hip-knee cyclograms, which show inter-joint coordination and visualized gait cycle in stroke patients, are clinically significant. [ABSTRACT FROM AUTHOR]

With the ubiquity of wearable devices, various behavioural biometrics have been exploited for continuous user authentication during daily activities. However, biometric authentication using complex hand behaviours have not been sufficiently investigated. This paper presents an implicit and continuous user authentication model based on hand-object manipulation behaviour, using a finger-and hand-mounted inertial measurement unit (IMU)-based system and state-of-the-art deep learning models. We employed three convolutional neural network (CNN)-based deep residual networks (ResNets) with multiple depths (i.e., 50, 101, and 152 layers) and two recurrent neural network (RNN)-based long short-term memory (LSTMs): simple and bidirectional. To increase ecological validity, data collection of hand-object manipulation behaviours was based on three different age groups and simple and complex daily object manipulation scenarios. As a result, both the ResNets and LSTMs models acceptably identified users' hand behaviour patterns, with the best average accuracy of 96.31% and F1-score of 88.08%. Specifically, in the simple hand behaviour authentication scenarios, more layers in residual networks tended to show better performance without showing conventional degradation problems (the ResNet-152 > ResNet-101 > ResNet-50). In a complex hand behaviour scenario, the ResNet models outperformed user authentication compared to the LSTMs. The 152-layered ResNet and bidirectional LSTM showed an average false rejection rate of 8.34% and 16.67% and an equal error rate of 1.62% and 9.95%, respectively. [ABSTRACT FROM AUTHOR]

Hand functions affect the instrumental activities of daily living. While functional outcome measures, such as a targeted box and block test, have been widely used in clinical settings and provide a useful measure of overall performance, the advent of a wearable Inertial Measurement Unit(IMU)-based system enables the examination of the specific performance and kinematic parameters of hand movements. This study proposed a novel clip-on IMU system to facilitate the clinically fitted measurements of fine-motor finger and wrist joint movements. Clinical validation was conducted with the aim of characterising age-related changes in hand functions, namely grasping, transporting, and releasing blocks. Eighteen young (age 20–31) and sixteen healthy older adults (age 75–89) were evaluated during the box and block test. The results demonstrated that an older age was characterized by slower movements and higher variations and kinematic alterations in the hand functions, such as a larger range of motions at the fingers as well as kinematic trajectories. The proposed IMU system and subsequent validations highlight the value of the performance and kinematics parameters for a more comprehensive understanding of fine-motor finger and wrist movements that could shed light on further implementations in clinical and practical settings. [ABSTRACT FROM AUTHOR]