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Soil organic carbon (SOC), as the largest carbon pool on the land surface, plays an important role in soil quality, ecological security and the global carbon cycle. Multisource remote sensing data-driven modeling strategies are not well understood for accurately mapping soil organic carbon. Here, we hypothesized that the Sentinel-2 Multispectral Sensor Instrument (MSI) data-driven modeling strategy produced superior outcomes compared to modeling based on Landsat 8 Operational Land Imager (OLI) data due to the finer spatial and spectral resolutions of the Sentinel-2A MSI data. To test this hypothesis, the Ebinur Lake wetland in Xinjiang was selected as the study area. In this study, SOC estimation was carried out using Sentinel-2A and Landsat 8 data, combining climatic variables, topographic factors, index variables and Sentinel-1A data to construct a common variable model for Sentinel-2A data and Landsat 8 data, and a full variable model for Sentinel-2A data, respectively. We utilized ensemble learning algorithms to assess the prediction performance of modeling strategies, including random forest (RF), gradient boosted decision tree (GBDT) and extreme gradient boosting (XGBoost) algorithms. The results show that: (1) The Sentinel-2A model outperformed the Landsat 8 model in the prediction of SOC contents, and the Sentinel-2A full variable model under the XGBoost algorithm achieved the best results R2 = 0.804, RMSE = 1.771, RPIQ = 2.687). (2) The full variable model of Sentinel-2A with the addition of the red-edge band and red-edge index improved R2 by 6% and 3.2% over the common variable Landsat 8 and Sentinel-2A models, respectively. (3) In the SOC mapping of the Ebinur Lake wetland, the areas with higher SOC content were mainly concentrated in the oasis, while the mountainous and lakeside areas had lower SOC contents. Our results provide a program to monitor the sustainability of terrestrial ecosystems through a satellite perspective. [ABSTRACT FROM AUTHOR]