1. Sentinel lymph node mapping opens a new perspective in the surgical management of early-stage breast cancer: a combined approach with vital blue dye lymphatic mapping and radioguided surgery
- Author
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Giuseppe Canavese, Giuseppe Villa, Franca Carli, Luciano Moresco, Ferdinando Cafiero, Guido Nicolò, Marco Gipponi, A. Catturich, Carlo Vecchio, Carmine Di Somma, Daniela Tomei, Francesco Rosato, Fausto Badellino, and Ferdinando Buffoni
- Subjects
medicine.medical_specialty ,Pathology ,Sentinel lymph node ,H&E stain ,Breast Neoplasms ,Sensitivity and Specificity ,Intraoperative Period ,Breast cancer ,pathology/radionuclide imaging ,Predictive Value of Tests ,Aged, Axilla, Breast Neoplasms ,pathology/radionuclide imaging/surgery, Coloring Agents ,diagnostic use, Female, Humans, Immunohistochemistry, Intraoperative Period, Lymph Node Excision, Lymph Nodes ,pathology/radionuclide imaging, Lymphatic Metastasis, Middle Aged, Neoplasm Staging, Predictive Value of Tests, Radioimmunodetection, Sensitivity and Specificity, Technetium Tc 99m Aggregated Albumin ,diagnostic use, Technetium Tc 99m Sulfur Colloid ,diagnostic use ,Medicine ,Humans ,Stage (cooking) ,Coloring Agents ,Lymph node ,Technetium Tc 99m Aggregated Albumin ,Aged ,Neoplasm Staging ,business.industry ,Melanoma ,Middle Aged ,medicine.disease ,Immunohistochemistry ,Axilla ,pathology/radionuclide imaging/surgery ,medicine.anatomical_structure ,Oncology ,Radioimmunodetection ,Lymphatic Metastasis ,Technetium Tc 99m Sulfur Colloid ,Lymph Node Excision ,Surgery ,Female ,Radiology ,Lymph Nodes ,business - Abstract
Recent studies have demonstrated the possibility of identifying the sentinel lymph node (sN) as a reliable predictor of axillary lymph node status in both cutaneous melanoma and breast cancer. However, some important issues need further definition: (1) optimization of the technique for intraoperative detection of the sN; (2) predictive value of the sN as regards axillary lymph node status, and (3) reliability of intraoperative histology of the sN. We report our experience in sN mapping in patients with Stage I-II breast cancer, with the aim of assessing: (1) the feasibility of lymphatic mapping with a combined approach (vital blue dye lymphatic mapping and radioguided surgery); (2) the agreement of the intraoperative histologic examination of the sN, by means of hematoxylin and eosin staining with final histology, and (3) the accuracy of sN histology as a predictor of axillary lymph node status.
- Published
- 1998