1. Clinicopathologic factors influencing the long-term prognosis following hepatic resection for large hepatocellular carcinoma more than 10 cm in diameter.
- Author
-
Noguchi T, Kawarada Y, Kitagawa M, Ito F, Sakurai H, Machishi H, Yamagiwa K, Yokoi H, and Mizumoto R
- Subjects
- Adult, Aged, Carcinoma, Hepatocellular genetics, Carcinoma, Hepatocellular mortality, Carcinoma, Hepatocellular pathology, DNA, Neoplasm genetics, Humans, Liver Neoplasms genetics, Liver Neoplasms mortality, Liver Neoplasms pathology, Male, Middle Aged, Neoplasm Invasiveness, Palliative Care, Ploidies, Portal Vein pathology, Prognosis, Survival Rate, Carcinoma, Hepatocellular surgery, Liver Neoplasms surgery
- Abstract
We resected 158 cases of hepatocellular carcinoma (HCC), including 20 (12.6%) cases of large HCC. These 20 cases were divided into group 1 (curative resection, n = 9) and group 2 (noncurative resection, n = 11). The clinicopathologic features and long-term survival of the cases were evaluated. In groups 1 and 2, portal vein invasion (Vp+) was noted in 44.4% and 63.3%, intrahepatic metastasis (IM+) in 77.8% and 100%, absence of a fibrous capsule (Fc-) in 55.6% and 63.6%, and stage III or IV in 77.8% and 100%, respectively. The DNA ploidy pattern was aneuploid in 44.4% of group 1 and 100% of group 2. In group 1, the 1-, 3-, and 5-year cumulative survival rates were 75%, 62.5%, and 62.5%, respectively (the longest survivor is alive after 11 years 1 month). Five cases survived more than 3 years in group 1, and all were Vp(-) and nonaneuploid. On the other hand, in group 2, the 1-year survival rate was only 33.3%; none survived more than 2 years. These results suggest that even patients with large HCC have a favorable long-term prognosis if their clinicopathologic factors are Vp(-) and nonaneuploid, and if curative resection can be performed.
- Published
- 1997