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2 results on '"E. Bernardoni"'

1. Efficacy and safety of topiramate in infants according to epilepsy syndromes

Author

Rosa Mostardini, Salvatore Grosso, Daniela Galimberti, R. Vivarelli, Maddalena Cioni, R.M. Di Bartolo, E. Bernardoni, M. A. Farnetani, Rosario Berardi, Paolo Balestri, and Guido Morgese

Subjects
Topiramate, Male, Pediatrics, medicine.medical_specialty, Spasm, Fever, Population, Antiepileptic drugs, Clinical Neurology, Fructose, Irritability, Epilepsy, Drug resistant epilepsy, Epilepsy syndrome, Infantile spasms, Medicine, Humans, Generalized epilepsy, education, Retrospective Studies, education.field_of_study, business.industry, Infant, Newborn, Infant, Retrospective cohort study, General Medicine, Drug Resistant Epilepsy, medicine.disease, Anorexia, Treatment Outcome, Neurology, Anesthesia, Epilepsy syndromes, Anticonvulsants, Female, Neurology (clinical), Sleep Stages, medicine.symptom, business, medicine.drug, Follow-Up Studies
Abstract

SummaryStudies of the efficacy of topiramate (TPM) in infants and young children are few. Here we report an open, prospective, and pragmatic study of effectiveness of TPM in terms of epilepsy syndromes, in children aged less than 2 years. The median follow-up period was 11 months. We enrolled 59 children in the study: 22 affected by localization-related epilepsy (LRE), 23 by generalized epilepsy, six by Dravet's syndrome, and eight with unclassifiable epilepsy. TPM was effective (responders showed a decrease of more than 50% in seizure frequency) in 47% of patients, including 13% who were seizure-free at the last visit. TPM was more effective in localization-related epilepsy (48% of responders) than in generalized epilepsy (32% of responders). In the latter group, 19 patients suffered from infantile spasms. Four of six patients with cryptogenic infantile spasms became seizure-free. Of the 13 patients with symptomatic infantile spasms, only one was seizure-free. Results were poor for patients with Dravet's syndrome. In general, TPM was well tolerated. The most frequently reported adverse effects were drowsiness, irritability, hyperthermia, and anorexia.The present study concludes that TPM is effective for a broad range of seizures in infants and young children and represents a valid therapeutic option in this population.

Published
2005

2. Efficacy and safety of topiramate in infants according to epilepsy syndromes.

Author

Grosso S, Galimberti D, Farnetani MA, Cioni M, Mostardini R, Vivarelli R, Di Bartolo RM, Bernardoni E, Berardi R, Morgese G, and Balestri P

Subjects
Anorexia chemically induced, Anticonvulsants adverse effects, Epilepsy complications, Female, Fever chemically induced, Follow-Up Studies, Fructose adverse effects, Humans, Infant, Infant, Newborn, Male, Retrospective Studies, Sleep Stages drug effects, Spasm drug therapy, Spasm etiology, Topiramate, Anticonvulsants therapeutic use, Epilepsy diagnosis, Epilepsy drug therapy, Fructose analogs & derivatives, Fructose therapeutic use, Treatment Outcome
Abstract

Studies of the efficacy of topiramate (TPM) in infants and young children are few. Here we report an open, prospective, and pragmatic study of effectiveness of TPM in terms of epilepsy syndromes, in children aged less than 2 years. The median follow-up period was 11 months. We enrolled 59 children in the study: 22 affected by localization-related epilepsy (LRE), 23 by generalized epilepsy, six by Dravet's syndrome, and eight with unclassifiable epilepsy. TPM was effective (responders showed a decrease of more than 50% in seizure frequency) in 47% of patients, including 13% who were seizure-free at the last visit. TPM was more effective in localization-related epilepsy (48% of responders) than in generalized epilepsy (32% of responders). In the latter group, 19 patients suffered from infantile spasms. Four of six patients with cryptogenic infantile spasms became seizure-free. Of the 13 patients with symptomatic infantile spasms, only one was seizure-free. Results were poor for patients with Dravet's syndrome. In general, TPM was well tolerated. The most frequently reported adverse effects were drowsiness, irritability, hyperthermia, and anorexia. The present study concludes that TPM is effective for a broad range of seizures in infants and young children and represents a valid therapeutic option in this population.

Published
2005
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