1. Switching of Higher-Order Structure of DNA and Gene Expression
- Author
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Kanta Tsumoto, Kenichi Yoshikawa, and Yuko Yoshikawa
- Subjects
Transcriptional activity ,chemistry.chemical_compound ,chemistry ,Discrete transition ,Gene expression ,Morphological variation ,Structural transition ,Biology ,Higher Order Structure ,Molecular biology ,DNA ,Cell biology ,Chromatin - Abstract
Long DNA molecules above the size of several tens kbp undergo marked discrete transition on their higher-order structure. Recent study on single molecular chain observation indicates that the structural transition of DNA induces discrete ON/OFF switching on transcriptional activity. Changes of environmental parameters induce the morphological variation in folded DNA. We propose a hypothesis that appearance of partially unfolded part on chromatin may concern with the promotion of gene expression.
- Published
- 2002
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