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28 results on '"Zhu, Jin"'

9. Role and mechanism of AT1-AA in the pathogenesis of HELLP syndrome

Author

Yuxian Wang, Jianming Zhi, Zhu Jin, Shuqing Sun, Yanqian Zheng, and Shurui Bu

Subjects
0301 basic medicine, lcsh:Medicine, Pathogenesis, 0302 clinical medicine, Pregnancy, Medicine, lcsh:Science, Membrane Potential, Mitochondrial, 030219 obstetrics & reproductive medicine, Multidisciplinary, Endothelin-1, Middle Aged, Hemolysis, Titer, Losartan, Liver, cardiovascular system, Female, hormones, hormone substitutes, and hormone antagonists, medicine.drug, circulatory and respiratory physiology, Adult, medicine.medical_specialty, HELLP Syndrome, HELLP syndrome, Enzyme-Linked Immunosorbent Assay, Article, Receptor, Angiotensin, Type 1, 03 medical and health sciences, Young Adult, Internal medicine, Renin–angiotensin system, Animals, Humans, Autoantibodies, 030102 biochemistry & molecular biology, business.industry, Tumor Necrosis Factor-alpha, lcsh:R, Case-control study, medicine.disease, Rats, Disease Models, Animal, Endocrinology, Case-Control Studies, Hepatocytes, lcsh:Q, business, Biomarkers
Abstract

HELLP syndrome remains a leading cause of maternal and neonatal mortality and morbidity worldwide, which symptoms include hemolysis, elevated liver enzymes and low platelet count. The objective of this study was to determine whether HELLP is associated with AT1-AA. The positive rate and titer of AT1-AA in plasma from pregnant women were determined, and the correlation of AT1-AA titer with the grade of HELLP was analyzed. A HELLP rat model established by intravenous injection of AT1-AA. Our experimental results show the AT1-AA titer and positive rate were significantly higher in HELLP group, and AT1-AA titer were positively correlated with the level of TNF-α and ET-1 in plasma and the grade of HELLP syndrome. The results of animal experiments showed that the typical features of HELLP in the pregnant rats after AT1-AA injection. The levels of TNF-α and ET-1 in plasma and liver tissue were significantly increased in AT1-AA-treated rats compared with control rats. The HELLP syndrome induced by AT1-AA was attenuated markedly after administration of losartan. These data support the hypothesis that one the potential pathway that AT1-AA induce damage to capillary endothelial cells and liver during pregnancy is through activation of TNF-α and ET-1.

Published
2018

10. Therapeutic effects of hepatocyte growth factor-overexpressing dental pulp stem cells on liver cirrhosis in a rat model

Author

Liang Sun, Feng Lin, Ying Li, Xiaofang Cao, Bin Zhang, Yuanbo Zhan, Ying-lian Zhou, Shi-zhu Jin, Li Gao, and Xiumei Wang

Subjects
0301 basic medicine, Liver Cirrhosis, medicine.medical_specialty, Cirrhosis, medicine.medical_treatment, Intraperitoneal injection, lcsh:Medicine, CCL4, Gastroenterology, Article, Rats, Sprague-Dawley, 03 medical and health sciences, stomatognathic system, Internal medicine, Dental pulp stem cells, medicine, Animals, lcsh:Science, Dental Pulp, Multidisciplinary, business.industry, Hepatocyte Growth Factor, Growth factor, Stem Cells, lcsh:R, Cell Differentiation, Recovery of Function, medicine.disease, Transplantation, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Hepatocyte, Cancer research, lcsh:Q, Hepatocyte growth factor, Female, business, medicine.drug
Abstract

Cirrhosis is the terminal stage of hepatic diseases and is prone to develop into hepatocyte carcinoma. Increasing evidence suggests that the transplantation of dental pulp stem cells (DPSCs) may promote recovery from cirrhosis, but the key regulatory mechanisms involved remain to be determined. In this study, we overexpressed human hepatocyte growth factor (hHGF) in primary rat DPSCs and evaluated the effects of HGF overexpression on the biological behaviors and therapeutic efficacy of grafted DPSCs in cirrhosis. Liver cirrhosis was induced via the intraperitoneal injection of CCl4 twice weekly for 12 weeks and was verified through histopathological and serological assays. HGF was overexpressed in DPSCs via transduction with a hHGF-lentiviral vector and confirmed based on the elevated expression and secretion of HGF. The HGF-overexpressing DPSCs were transplanted into rats intravenously. The HGF-overexpressing DPSCs showed increased survival and hepatogenic differentiation in host liver tissue at 6 weeks after grafting. They also exhibited a significantly greater repair potential in relation to cirrhosis pathology and impaired liver function than did DPSCs expressing HGF at physiological levels. Our study may provide an experimental basis for the development of novel methods for the treatment of liver cirrhosis in clinical practice.

Published
2017

11. Core-shell nanocarriers with high paclitaxel loading for passive and active targeting

Author

Hui Cao, Jianping Zhou, Wei He, Jing Yao, Yaqi Lv, Zhu Jin, and Lifang Yin

Subjects
Paclitaxel, Cell Survival, Antineoplastic Agents, Apoptosis, 02 engineering and technology, Pharmacology, Ligands, 010402 general chemistry, Endocytosis, behavioral disciplines and activities, 01 natural sciences, Article, Nanocapsules, chemistry.chemical_compound, Membrane Microdomains, In vivo, Cell Line, Tumor, mental disorders, Animals, Humans, Particle Size, Cytotoxicity, Drug Carriers, Multidisciplinary, Dose-Response Relationship, Drug, 021001 nanoscience & nanotechnology, Lipids, Rats, 0104 chemical sciences, Nanomedicine, Solubility, chemistry, A549 Cells, Drug delivery, Biophysics, Nanocarriers, 0210 nano-technology, Drug carrier, Oligopeptides, Neoplasm Transplantation
Abstract

Rapid blood clearance and premature burst release are inherent drawbacks of conventional nanoparticles, resulting in poor tumor selectivity. iRGD peptide is widely recognized as an efficient cell membrane penetration peptide homing to αVβ3 integrins. Herein, core-shell nanocapsules (NCs) and iRGD-modified NCs (iRGD-NCs) with high drug payload for paclitaxel (PTX) were prepared to enhance the antitumor activities of chemotherapy agents with poor water solubility. Improved in vitro and in vivo tumor targeting and penetration were observed with NCs and iRGD-NCs; the latter exhibited better antitumor activity because iRGD enhanced the accumulation and penetration of NCs in tumors. The NCs were cytocompatible, histocompatible, and non-toxic to other healthy tissues. The endocytosis of NCs was mediated by lipid rafts in an energy-dependent manner, leading to better cytotoxicity of PTX against cancer cells. In contrast with commercial product, PTX-loaded NCs (PTX-NCs) increased area under concentration-time curve (AUC) by about 4-fold, prolonged mean resident time (MRT) by more than 8-fold and reduced the elimination rate constant by greater than 68-fold. In conclusion, the present nanocarriers with high drug-loading capacity represent an efficient tumor-targeting drug delivery system with promising potential for cancer therapy.

Published
2016
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12. Virome analysis for identification of novel mammalian viruses in bats from Southeast China

Author

Hu, Dan, primary, Zhu, Changqiang, additional, Wang, Yi, additional, Ai, Lele, additional, Yang, Lu, additional, Ye, Fuqiang, additional, Ding, Chenxi, additional, Chen, Jiafeng, additional, He, Biao, additional, Zhu, Jin, additional, Qian, Hui, additional, Xu, Wenrong, additional, Feng, Youjun, additional, Tan, Weilong, additional, and Wang, Changjun, additional

Published
2017
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18. Prognostic value of decreased expression of RBM4 in human gastric cancer

Author

Yong, Hongmei, primary, Zhu, Huijun, additional, Zhang, Shu, additional, Zhao, Wei, additional, Wang, Wei, additional, Chen, Chen, additional, Ding, Guipeng, additional, Zhu, Lun, additional, Zhu, Ziyuan, additional, Liu, Huaidong, additional, Zhang, Yongjie, additional, Wen, Jinbo, additional, Kang, Xing, additional, Zhu, Jin, additional, Feng, Zhenqing, additional, and Liu, Baorui, additional

Published
2016
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19. Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H

Author

Xiao, Qiang, primary, Dong, Ningning, additional, Yao, Xue, additional, Wu, Dang, additional, Lu, Yanli, additional, Mao, Fei, additional, Zhu, Jin, additional, Li, Jian, additional, Huang, Jin, additional, Chen, Aifang, additional, Huang, Lu, additional, Wang, Xuehai, additional, Yang, Guangxiao, additional, He, Guangyuan, additional, Xu, Yong, additional, and Lu, Weiqiang, additional

Published
2016
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27. The β-galactosidase (BgaC) of the zoonotic pathogen Streptococcus suis is a surface protein without the involvement of bacterial virulence

Author

Hu, Dan, primary, Zhang, Fengyu, additional, Zhang, Huimin, additional, Hao, Lina, additional, Gong, Xiufang, additional, Geng, Meiling, additional, Cao, Min, additional, Zheng, Feng, additional, Zhu, Jin, additional, Pan, Xiuzhen, additional, Tang, Jiaqi, additional, Feng, Youjun, additional, and Wang, Changjun, additional

Published
2014
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