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4 results on '"Zhipeng Yao"'

1. Identifying and exploring the favorable factors that help to slow the progression of disease in patients with mild cervical spondylotic myelopathy

Author

Taotao Lin, Zhipeng Yao, Zhehao Xiao, Rongcan Wu, Yujie Zhao, Dehui Chen, Linquan Zhou, Zhenyu Wang, and Wenge Liu

Subjects
Mild cervical spondylotic myelopathy, Slow disease progression, Cervical vertebra sagittal parameters, Paravertebral muscle degeneration, Compression degree of the cervical spinal cord, Compression degree of the spinal canal, Medicine, Science
Abstract

Abstract To explore the favorable factors that help slow the progression of disease in patients with mild Cervical Spondylotic Myelopathy (CSM). A retrospective analysis was conducted, involving the enrollment of 115 CSM patients. The categorization of patients into two groups was based on the duration of symptoms, assessments using the mJOA scale and Health Transition (HT) scores: mild-slow group and severe-rapid group. We found that the patients in both groups had similar degrees of spinal cord compression, but mild-slow group were older and had smaller C2–C7 cobb angle (Flexion) (CL(F)), C2–C7 cobb angle (Range of motion) (CL(ROM)), Transverse area (TA), Normal-TA, Compressive spinal canal area (CSCA), Normal-Spinal canal area (Normal-SCA) and lower Spinal cord increased signal intensity (ISI) Grade than the severe-rapid group. A binary logistic regression analysis showed that CL(ROM) and Normal-TA are favorable factors to help slow the progression of disease patients with mild CSM. Through ROC curves, we found that when CL(ROM)

Published
2024
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2. Phosphatidylserine-mediated platelet clearance by endothelium decreases platelet aggregates and procoagulant activity in sepsis

Author

Ruishuang Ma, Rui Xie, Chengyuan Yu, Yu Si, Xiaoming Wu, Lu Zhao, Zhipeng Yao, Shaohong Fang, He Chen, Valerie Novakovic, Chunyan Gao, Junjie Kou, Yayan Bi, Hemant S. Thatte, Bo Yu, Shufen Yang, Jin Zhou, and Jialan Shi

Subjects
Medicine, Science
Abstract

Abstract The mechanisms that eliminate activated platelets in inflammation-induced disseminated intravascular coagulation (DIC) in micro-capillary circulation are poorly understood. This study explored an alternate pathway for platelet disposal mediated by endothelial cells (ECs) through phosphatidylserine (PS) and examined the effect of platelet clearance on procoagulant activity (PCA) in sepsis. Platelets in septic patients demonstrated increased levels of surface activation markers and apoptotic vesicle formation, and also formed aggregates with leukocytes. Activated platelets adhered were and ultimately digested by ECs in vivo and in vitro. Blocking PS on platelets or αvβ3 integrin on ECs attenuated platelet clearance resulting in increased platelet count in a mouse model of sepsis. Furthermore, platelet removal by ECs resulted in a corresponding decrease in platelet-leukocyte complex formation and markedly reduced generation of factor Xa and thrombin on platelets. Pretreatment with lactadherin significantly increased phagocytosis of platelets by approximately 2-fold, diminished PCA by 70%, prolonged coagulation time, and attenuated fibrin formation by 50%. Our results suggest that PS-mediated clearance of activated platelets by the endothelium results in an anti-inflammatory, anticoagulant, and antithrombotic effect that contribute to maintaining platelet homeostasis during acute inflammation. These results suggest a new therapeutic target for impeding the development of DIC.

Published
2017
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3. Phosphatidylserine-mediated platelet clearance by endothelium decreases platelet aggregates and procoagulant activity in sepsis

Author

Xiaoming Wu, Hemant S. Thatte, Zhipeng Yao, Bo Yu, Shufen Yang, Jin Zhou, Shaohong Fang, Yu Si, He Chen, Valerie A. Novakovic, Jialan Shi, Junjie Kou, Yayan Bi, Lu Zhao, Chengyuan Yu, Ruishuang Ma, Rui Xie, and Chunyan Gao

Subjects
0301 basic medicine, Science, Inflammation, 030204 cardiovascular system & hematology, Pharmacology, Fibrin, Article, 03 medical and health sciences, 0302 clinical medicine, Thrombin, medicine, Platelet, Platelet activation, Lactadherin, Disseminated intravascular coagulation, Multidisciplinary, biology, business.industry, medicine.disease, 030104 developmental biology, Immunology, biology.protein, Medicine, medicine.symptom, business, Platelet factor 4, medicine.drug
Abstract

The mechanisms that eliminate activated platelets in inflammation-induced disseminated intravascular coagulation (DIC) in micro-capillary circulation are poorly understood. This study explored an alternate pathway for platelet disposal mediated by endothelial cells (ECs) through phosphatidylserine (PS) and examined the effect of platelet clearance on procoagulant activity (PCA) in sepsis. Platelets in septic patients demonstrated increased levels of surface activation markers and apoptotic vesicle formation, and also formed aggregates with leukocytes. Activated platelets adhered were and ultimately digested by ECs in vivo and in vitro. Blocking PS on platelets or αvβ3 integrin on ECs attenuated platelet clearance resulting in increased platelet count in a mouse model of sepsis. Furthermore, platelet removal by ECs resulted in a corresponding decrease in platelet-leukocyte complex formation and markedly reduced generation of factor Xa and thrombin on platelets. Pretreatment with lactadherin significantly increased phagocytosis of platelets by approximately 2-fold, diminished PCA by 70%, prolonged coagulation time, and attenuated fibrin formation by 50%. Our results suggest that PS-mediated clearance of activated platelets by the endothelium results in an anti-inflammatory, anticoagulant, and antithrombotic effect that contribute to maintaining platelet homeostasis during acute inflammation. These results suggest a new therapeutic target for impeding the development of DIC.

Published
2017

4. Publisher Correction: Phosphatidylserine-mediated platelet clearance by endothelium decreases platelet aggregates and procoagulant activity in sepsis

Author

Jin Zhou, Zhipeng Yao, Ruishuang Ma, Jialan Shi, Chunyan Gao, Hemant S. Thatte, Xiaoming Wu, Yayan Bi, Bo Yu, Shaohong Fang, Junjie Kou, Lu Zhao, Chengyuan Yu, Yu Si, Valerie A. Novakovic, Shufen Yang, He Chen, and Rui Xie

Subjects
Adult, Blood Platelets, Male, Endothelium, lcsh:Medicine, Phosphatidylserines, Pharmacology, Sepsis, chemistry.chemical_compound, Cell-Derived Microparticles, Human Umbilical Vein Endothelial Cells, Leukocytes, Medicine, Humans, Platelet, lcsh:Science, Blood Coagulation, Multidisciplinary, business.industry, lcsh:R, Endothelial Cells, Phosphatidylserine, Middle Aged, medicine.disease, Platelet Activation, Publisher Correction, medicine.anatomical_structure, chemistry, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, lcsh:Q, Female, Endothelium, Vascular, business
Abstract

The mechanisms that eliminate activated platelets in inflammation-induced disseminated intravascular coagulation (DIC) in micro-capillary circulation are poorly understood. This study explored an alternate pathway for platelet disposal mediated by endothelial cells (ECs) through phosphatidylserine (PS) and examined the effect of platelet clearance on procoagulant activity (PCA) in sepsis. Platelets in septic patients demonstrated increased levels of surface activation markers and apoptotic vesicle formation, and also formed aggregates with leukocytes. Activated platelets adhered were and ultimately digested by ECs in vivo and in vitro. Blocking PS on platelets or αvβ3 integrin on ECs attenuated platelet clearance resulting in increased platelet count in a mouse model of sepsis. Furthermore, platelet removal by ECs resulted in a corresponding decrease in platelet-leukocyte complex formation and markedly reduced generation of factor Xa and thrombin on platelets. Pretreatment with lactadherin significantly increased phagocytosis of platelets by approximately 2-fold, diminished PCA by 70%, prolonged coagulation time, and attenuated fibrin formation by 50%. Our results suggest that PS-mediated clearance of activated platelets by the endothelium results in an anti-inflammatory, anticoagulant, and antithrombotic effect that contribute to maintaining platelet homeostasis during acute inflammation. These results suggest a new therapeutic target for impeding the development of DIC.

Published
2018

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