Search

Your search keyword '"Yokota, Takashi"' showing total 10 results
Start Over Author "Yokota, Takashi" Journal scientific reports
10 results on '"Yokota, Takashi"'

1. Author Correction: Enhanced mitochondrial oxidative metabolism in peripheral blood mononuclear cells is associated with fatty liver in obese young adults

Author

Shirakawa, Ryosuke, Nakajima, Takayuki, Yoshimura, Aya, Kawahara, Yukako, Orito, Chieko, Yamane, Miwako, Handa, Haruka, Takada, Shingo, Furihata, Takaaki, Fukushima, Arata, Ishimori, Naoki, Nakagawa, Masao, Yokota, Isao, Sabe, Hisataka, Hashino, Satoshi, Kinugawa, Shintaro, and Yokota, Takashi

Published
2024
Full Text
View/download PDF

6. Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary atherosclerosis

Author

Nakajima, Takayuki, Yokota, Takashi, Shingu, Yasushige, Yamada, Akira, Iba, Yutaka, Ujihira, Kosuke, Wakasa, Satoru, Ooka, Tomonori, Takada, Shingo, Shirakawa, Ryosuke, Katayama, Takashi, Furihata, Takaaki, Fukushima, Arata, Matsuoka, Ryosuke, Nishihara, Hiroshi, Dela, Flemming, Nakanishi, Katsuhiko, Matsui, Yoshiro, and Kinugawa, Shintaro

Published
2019
Full Text
View/download PDF

7. Luseogliflozin preserves the pancreatic beta-cell mass and function in db/db mice by improving mitochondrial function

Author

Yamauchi, Yuki, Nakamura, Akinobu, Yokota, Takashi, Takahashi, Kiyohiko, Kawata, Shinichiro, Tsuchida, Kazuhisa, Omori, Kazuno, Nomoto, Hiroshi, Kameda, Hiraku, Cho, Kyu Yong, Anzai, Toshihisa, Tanaka, Shinya, Terauchi, Yasuo, Miyoshi, Hideaki, and Atsumi, Tatsuya

Subjects
Mice, Multidisciplinary, Diabetes Mellitus, Type 2, Insulin-Secreting Cells, Animals, Sorbitol, Mice, Inbred Strains, Reactive Oxygen Species, Sodium-Glucose Transporter 2 Inhibitors, Mitochondria
Abstract

We aimed to determine the mechanism by which the sodium glucose co-transporter 2 inhibitor, luseogliflozin, preserves pancreatic beta-cell mass and function in db/db mice. Six-week-old db/db mice were fed to standard chow or standard chow containing 0.01% luseogliflozin. After 4 weeks, DNA microarray analysis, real-time PCR analysis, and measurement of mitochondrial respiratory capacity and reactive oxygen species (ROS) generation were performed using isolated islets. Immunohistochemistry and electron microscopic analysis were performed using pancreatic tissues. Metabolites extracted from the islets were measured by capillary electrophoresis mass spectrometry. The expression of genes involved in the tricarboxylic acid (TCA) cycle and electron transport chain was upregulated by luseogliflozin. Luseogliflozin improved the mitochondrial complex II-linked oxidative phosphorylation capacity and reduced ROS generation. Mitochondrial morphology was normally maintained by luseogliflozin. Luseogliflozin increased NK6 homeobox 1 (NKX6.1) expression and TCA cycle metabolites. Relief of glucotoxicity by luseogliflozin may involve lower mitochondrial ROS generation and an improvement in complex II-linked mitochondrial respiration. Reducing ROS generation through preventing complex II damage likely increases NKX6.1 expression and ameliorate glucose metabolism in the TCA cycle, contributing to the protection of pancreatic beta-cells. Protection of complex II in pancreatic beta-cells represents a novel therapeutic target for type 2 diabetes.

Published
2021

10. Cortisol overproduction results from DNA methylation of CYP11B1 in hypercortisolemia

Author

Kometani, Mitsuhiro, primary, Yoneda, Takashi, additional, Demura, Masashi, additional, Koide, Hiroshi, additional, Nishimoto, Koshiro, additional, Mukai, Kuniaki, additional, Gomez-Sanchez, Celso E., additional, Akagi, Tadayuki, additional, Yokota, Takashi, additional, Horike, Shin-ichi, additional, Karashima, Shigehiro, additional, Miyamori, Isamu, additional, Yamagishi, Masakazu, additional, and Takeda, Yoshiyu, additional

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results