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Your search keyword '"Yan-Jun Lu"' showing total 2 results
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2 results on '"Yan-Jun Lu"'

1. Meta-analysis Reveals the Prognostic Value of Circulating Tumour Cells Detected in the Peripheral Blood in Patients with Non-Metastatic Colorectal Cancer

Author

Yan-jun Lu, Peng Wang, Jing Peng, Xiong Wang, Yao-wu Zhu, and Na Shen

Subjects
Medicine, Science
Abstract

Abstract Detecting circulating tumour cells (CTCs) is considered as effective and minimally invasive technique to predict the prognosis of patients with metastatic colorectal cancer (CRC), but its clinical validity is still conflicting in patients without metastasis. We performed this meta-analysis to evaluate whether detection of CTCs in the peripheral blood can be used as a prognostic marker for patients with non-metastatic CRC. We performed a comprehensive search of the EMBASE, PubMed, and Web of Science databases (up to September 2016). Meta-analyses were conducted using a random-effects model with the hazard ratio (HR) and 95% confidence interval (95% CI) as the effect measures. Twenty studies including 3,687 patients were eligible for inclusion. Overall analyses demonstrated that the presence of CTCs was significantly associated with aggressive disease progression (HR = 2.57, 95% CI = 1.64–4.02, P heterogeneity

Published
2017
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2. Promotive effects of bone morphogenetic protein 2 on angiogenesis in hepatocarcinoma via multiple signal pathways

Author

Yan-jun Lu, Wei-han Zuo, Peng Zeng, An Li, Xi Chen, and Jian-bin Wu

Subjects
0301 basic medicine, Vascular Endothelial Growth Factor A, animal structures, Carcinoma, Hepatocellular, Angiogenesis, Genetic Vectors, Bone Morphogenetic Protein 2, Bone morphogenetic protein 2, p38 Mitogen-Activated Protein Kinases, Article, Small hairpin RNA, Neovascularization, 03 medical and health sciences, Mice, 0302 clinical medicine, medicine, Human Umbilical Vein Endothelial Cells, Animals, Humans, RNA, Small Interfering, Protein kinase B, Cell Proliferation, Gene knockdown, Multidisciplinary, Mitogen-Activated Protein Kinase 3, Neovascularization, Pathologic, Chemistry, TOR Serine-Threonine Kinases, fungi, Lentivirus, Liver Neoplasms, Hep G2 Cells, Molecular biology, Coculture Techniques, Hep G2, Gene Expression Regulation, Neoplastic, Vascular endothelial growth factor A, 030104 developmental biology, 030220 oncology & carcinogenesis, embryonic structures, Cancer research, cardiovascular system, Female, medicine.symptom, Proto-Oncogene Proteins c-akt, Neoplasm Transplantation, Signal Transduction
Abstract

The effects of Bone morphogenetic protein 2 (BMP-2) on the angiogenesis of hepatocellular carcinoma have not yet been observed and its molecular mechanisms is not clear. We first constructed the recombinant lentivirus vectors expressing small hairpin RNA against BMP-2 gene (LV-SH-BMP2) and the recombinant lentivirus vectors over-expressing BMP-2 (overexpression-LV-BMP2), and then the two recombinant lentivirus vectors were respectively transfected into Hep G2 cells. The Hep G2 cells transfected with LV-SH-BMP2 or overexpression-LV-BMP2 were respectively co-cultured with human umbilical vein endothelial cells (HUVECs) to observe the effects of BMP-2 on HUVECs. The effect of BMP-2 on tumor microvessel density (MVD) was examined. The abilities of proliferation, migration and angiogenesis were significantly inhibited in the HUVECs co-cultured with BMP-2 knockdown Hep G2 (all P P P

Published
2016
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