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5 results on '"Weber, Franz E"'

3. Erratum: Longitudinal in vivo evaluation of bone regeneration by combined measurement of multi-pinhole SPECT and micro-CT for tissue engineering

Author

Lienemann, Philipp S., primary, Metzger, Stéphanie, additional, Kiveliö, Anna-Sofia, additional, Blanc, Alain, additional, Papageorgiou, Panagiota, additional, Astolfo, Alberto, additional, Pinzer, Bernd R., additional, Cinelli, Paolo, additional, Weber, Franz E., additional, Schibli, Roger, additional, Béhé, Martin, additional, and Ehrbar, Martin, additional

Published
2015
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4. Longitudinal in vivo evaluation of bone regeneration by combined measurement of multi-pinhole SPECT and micro-CT for tissue engineering

Author

Lienemann, Philipp S., primary, Metzger, Stéphanie, additional, Kiveliö, Anna-Sofia, additional, Blanc, Alain, additional, Papageorgiou, Panagiota, additional, Astolfo, Alberto, additional, Pinzer, Bernd R., additional, Cinelli, Paolo, additional, Weber, Franz E., additional, Schibli, Roger, additional, Béhé, Martin, additional, and Ehrbar, Martin, additional

Published
2015
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5. N,N Dimethylacetamide a drug excipient that acts as bromodomain ligand for osteoporosis treatment

Author

Amedeo Caflisch, Franz E. Weber, J. Dong, Bebeka Gjoksi, Barbara Siegenthaler, Chafik Ghayor, University of Zurich, and Weber, Franz E

Subjects
0301 basic medicine, Anti-Inflammatory Agents, Excipient, Cell Cycle Proteins, 610 Medicine & health, Pharmacology, Article, Bone resorption, Dimethylacetamide, Cell Line, Excipients, Rats, Sprague-Dawley, Mice, 03 medical and health sciences, chemistry.chemical_compound, Osteogenesis, In vivo, Osteoclast, Acetamides, 10019 Department of Biochemistry, medicine, Animals, Humans, Bone regeneration, 1000 Multidisciplinary, Multidisciplinary, Bone Density Conservation Agents, Chemistry, Nuclear Proteins, Ligand (biochemistry), 3. Good health, Bromodomain, 030104 developmental biology, medicine.anatomical_structure, 570 Life sciences, biology, Female, 10069 Clinic of Cranio-Maxillofacial Surgery, Protein Binding, Transcription Factors, medicine.drug
Abstract

N,N-Dimethylacetamide (DMA) is a water-miscible solvent, FDA approved as excipient and therefore widely used as drug-delivery vehicle. As such, DMA should be devoid of any bioactivity. Here we report that DMA is epigenetically active since it binds bromodomains and inhibits osteoclastogenesis and inflammation. Moreover, DMA enhances bone regeneration in vivo. Therefore, our in vivo and in vitro data reveal DMA’s potential as an anti-osteoporotic agent via the inhibition of osteoclast mediated bone resorption and enhanced bone regeneration. Our results highlight the potential therapeutic benefits of DMA and the need for reconsideration of previous reports where DMA was used as an ‘inactive’ drug-delivery vehicle.

Published
2017
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