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12 results on '"Toto, Lisa"'

3. A deep learning approach to hard exudates detection and disorganization of retinal inner layers identification on OCT images.

Author

Toto, Lisa, Romano, Anna, Pavan, Marco, Degl'Innocenti, Dante, Olivotto, Valentina, Formenti, Federico, Viggiano, Pasquale, Midena, Edoardo, and Mastropasqua, Rodolfo

Subjects
*OPTICAL coherence tomography, *DEEP learning, *EXUDATES & transudates, *DATA scrubbing, *MACULAR edema, *IMAGE analysis
Abstract

The purpose of the study was to detect Hard Exudates (HE) and classify Disorganization of Retinal Inner Layers (DRIL) implementing a Deep Learning (DL) system on optical coherence tomography (OCT) images of eyes with diabetic macular edema (DME). We collected a dataset composed of 442 OCT images on which we annotated 6847 HE and the presence of DRIL. A complex operational pipeline was defined to implement data cleaning and image transformations, and train two DL models. The state-of-the-art neural network architectures (Yolov7, ConvNeXt, RegNetX) and advanced techniques were exploited to aggregate the results (Ensemble learning, Edge detection) and obtain a final model. The DL approach reached good performance in detecting HE and classifying DRIL. Regarding HE detection the model got an AP@0.5 score equal to 34.4% with Precision of 48.7% and Recall of 43.1%; while for DRIL classification an Accuracy of 91.1% with Sensitivity and Specificity both of 91.1% and AUC and AUPR values equal to 91% were obtained. The P-value was lower than 0.05 and the Kappa coefficient was 0.82. The DL models proved to be able to identify HE and DRIL in eyes with DME with a very good accuracy and all the metrics calculated confirmed the system performance. Our DL approach demonstrated to be a good candidate as a supporting tool for ophthalmologists in OCT images analysis. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Transcriptomic analysis revealed increased expression of genes involved in keratinization in the tears of COVID-19 patients

Author

Mastropasqua, Leonardo, Toto, Lisa, Chiricosta, Luigi, Diomede, Francesca, Gugliandolo, Agnese, Silvestro, Serena, Marconi, Guya Diletta, Sinjari, Bruna, Vecchiet, Jacopo, Cipollone, Francesco, D’Ardes, Damiano, Auricchio, Antonio, Lanzini, Manuela, Caputi, Sergio, D’Aloisio, Rossella, Mazzon, Emanuela, and Trubiani, Oriana

Published
2021
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12. Relationship between aqueous humor cytokine level changes and retinal vascular changes after intravitreal aflibercept for diabetic macular edema

Author

Rodolfo Mastropasqua, Rossella D'Aloisio, Giuseppe Di Martino, Daniele Tognetto, Alessia Lamolinara, Lisa Toto, Luca Di Antonio, Marta Di Nicola, Mastropasqua, Rodolfo, D’Aloisio, Rossella, Di Nicola, Marta, Di Martino, Giuseppe, Lamolinara, Alessia, Di Antonio, Luca, Tognetto, Daniele, and Toto, Lisa

Subjects
0301 basic medicine, Eotaxin, Male, genetic structures, Computed Tomography Angiography, medicine.medical_treatment, Visual Acuity, Vascular permeability, Superficial Capillary Plexus (SCP), chemistry.chemical_compound, 0302 clinical medicine, Edema, Receptor, Aflibercept, Multidisciplinary, Middle Aged, Cytokine, Treatment Outcome, Intravitreal Injections, Medicine, Cytokines, Female, Diabetic Macular Edema (DME), medicine.symptom, Tomography, Optical Coherence, medicine.drug, medicine.medical_specialty, Central Macular Thickness (CMT), Science, Recombinant Fusion Proteins, Macular Edema, Article, Proinflammatory cytokine, Aqueous Humor, 03 medical and health sciences, Ophthalmology, medicine, Humans, Aged, Diabetic Retinopathy, business.industry, Retinal, eye diseases, 030104 developmental biology, Receptors, Vascular Endothelial Growth Factor, chemistry, Gene Expression Regulation, Vascular Endothelial Growth Factor (VEGF), 030221 ophthalmology & optometry, sense organs, business
Abstract

The aim of this work was to investigate the changes in aqueous humor cytokine levels after intravitreal injection of aflibercept in diabetic macular edema (DME) and to evaluate the relationship between cytokines modifications and central macular thickness (CMT) and retinal/choroidal vascular changes using structural and functional optical coherence tomography (OCT). Aqueous concentrations of 38 cytokines were measured via multiplex bead assay. In addition, spectral domain OCT and OCT angiography with SSADA software (XR Avanti® AngioVue) were performed at baseline and after intravitreal injections. VEGF, IL-6, IL-5, IL-1β, Eotaxin, GRO, IL-12p40, IL-12p70, IL-1RA, Flt-3L and IP-10 showed a statistically significant decrease through the follow-up (p

Published
2018

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