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30 results on '"Tang, Yan"'

16. White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function

Author

Chung, Youn Wook, primary, Ahmad, Faiyaz, additional, Tang, Yan, additional, Hockman, Steven C., additional, Kee, Hyun Jung, additional, Berger, Karin, additional, Guirguis, Emilia, additional, Choi, Young Hun, additional, Schimel, Dan M., additional, Aponte, Angel M., additional, Park, Sunhee, additional, Degerman, Eva, additional, and Manganiello, Vincent C., additional

Published
2017
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18. Predictive supracolloidal helices from patchy particles

Author

Xu-Ming Xie, Jian Mao, Ruohai Guo, and Li-Tang Yan

Subjects
Circular dichroism, Solid-state chemistry, Multidisciplinary, Computer science, Supramolecular chemistry, Rational design, Nanoparticle, Nanotechnology, Bioinformatics, Article, Colloid, Polymerization, Helix, Patchy particles
Abstract

A priori prediction of supracolloidal architectures from nanoparticle and colloidal assembly is a challenging goal in materials chemistry and physics. Despite intense research in this area, much less has been known about the predictive science of supracolloidal helices from designed building blocks. Therefore, developing conceptually new rules to construct supracolloidal architectures with predictive helicity is becoming an important and urgent task of great scientific interest. Here, inspired by biological helices, we show that the rational design of patchy arrangement and interaction can drive patchy particles to self-assemble into biomolecular mimetic supracolloidal helices. We further derive a facile design rule for encoding the target supracolloidal helices, thus opening the doors to the predictive science of these supracolloidal architectures. It is also found that kinetics and reaction pathway during the formation of supracolloidal helices offer a unique way to study supramolecular polymerization, and that well-controlled supracolloidal helices can exhibit tailorable circular dichroism effects at visible wavelengths.

Published
2014

20. The antinociception of oxytocin on colonic hypersensitivity in rats was mediated by inhibition of mast cell degranulation via Ca2+-NOS pathway

Author

Gong, Liping, primary, Li, Jing, additional, Tang, Yan, additional, Han, Ting, additional, Wei, Chuanfei, additional, Yu, Xiao, additional, Li, Jingxin, additional, Wang, Rong, additional, Ma, Xuelian, additional, Liu, Kejing, additional, Geng, Lingyun, additional, Liu, Shaozhuang, additional, Yan, Bing, additional, and Liu, Chuanyong, additional

Published
2016
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23. Elevated serum complement factors 3 and 4 are strong inflammatory markers of the metabolic syndrome development: a longitudinal cohort study

Author

Liu, Zhenfang, primary, Tang, Qin, additional, Wen, Jing, additional, Tang, Yan, additional, Huang, DaMin, additional, Huang, Yuzhen, additional, Xie, Jinling, additional, Luo, Yawen, additional, Liang, Min, additional, Wu, Chunlei, additional, Lu, Zheng, additional, Tan, Aihua, additional, Gao, Yong, additional, Wang, Qiuyan, additional, Jiang, Yonghua, additional, Yao, Ziting, additional, Lin, Xinggu, additional, Zhang, Haiying, additional, Mo, Zengnan, additional, and Yang, Xiaobo, additional

Published
2016
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25. A Nomogram for Predicting the Benefit of Adjuvant Cytokine-Induced Killer Cell Immunotherapy in Patients with Hepatocellular Carcinoma

Author

Pan, Qiu-Zhong, primary, Wang, Qi-Jing, additional, Dan, Jia-Qiang, additional, Pan, Ke, additional, Li, Yong-Qiang, additional, Zhang, Yao-Jun, additional, Zhao, Jing-Jing, additional, Weng, De-Sheng, additional, Tang, Yan, additional, Huang, Li-Xi, additional, He, Jia, additional, Chen, Shi-Ping, additional, Ke, Miao-La, additional, Chen, Min-Shan, additional, Wicha, Max S., additional, Chang, Alfred E., additional, Zeng, Yi-Xin, additional, Li, Qiao, additional, and Xia, Jian-Chuan, additional

Published
2015
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27. Predictive supracolloidal helices from patchy particles.

Author

Ruohai Guo, Jian Mao, Xu-Ming Xie, and Li-Tang Yan

Subjects
NANOPARTICLES, COLLOIDAL concrete, HELICES (Algebraic topology), POLYMERIZATION, WAVELENGTHS
Abstract

A priori prediction of supracolloidal architectures from nanoparticle and colloidal assembly is a challenging goal in materials chemistry and physics. Despite intense research in this area, much less has been known about the predictive science of supracolloidal helices from designed building blocks. Therefore, developing conceptually new rules to construct supracolloidal architectures with predictive helicity is becoming an important and urgent task of great scientific interest. Here, inspired by biological helices, we show that the rational design of patchy arrangement and interaction can drive patchy particles to self-assemble into biomolecular mimetic supracolloidal helices. We further derive a facile design rule for encoding the target supracolloidal helices, thus opening the doors to the predictive science of these supracolloidal architectures. It is also found that kinetics and reaction pathway during the formation of supracolloidal helices offer a unique way to study supramolecular polymerization, and that well-controlled supracolloidal helices can exhibit tailorable circular dichroism effects at visible wavelengths. [ABSTRACT FROM AUTHOR]

Published
2014
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30. Value of the NF-κB signalling pathway and the DNA repair gene PARP1 in predicting distant metastasis after breast cancer surgery.

Author

Pan K, Li X, He J, Lei Y, Yang Y, Jiang D, and Tang Y

Subjects
Humans, Female, I-kappa B Kinase metabolism, Tumor Necrosis Factor-alpha genetics, Tumor Necrosis Factor-alpha pharmacology, Case-Control Studies, Transcription Factor RelA metabolism, DNA Repair genetics, Poly (ADP-Ribose) Polymerase-1 genetics, Poly (ADP-Ribose) Polymerase-1 metabolism, NF-kappa B genetics, NF-kappa B metabolism, Breast Neoplasms genetics, Breast Neoplasms surgery
Abstract

The DNA repair gene PARP1 and NF-κB signalling pathway affect the metastasis of breast cancer by influencing the drug resistance of cancer cells. Therefore, this study focused on the value of the DNA repair gene PARP1 and NF-κB pathway proteins in predicting the postoperative metastasis of breast cancer. A nested case‒control study was performed. Immunohistochemical methods were used to detect the expression of these genes in patients. ROC curves were used to analyse the predictive effect of these factors on distant metastasis. The COX model was used to evaluate the effects of PARP1 and TNF-α on distant metastasis. The results showed that the expression levels of PARP1, IKKβ, p50, p65 and TNF-α were significantly increased in the metastasis group (P < 0.001). PARP1 was correlated with IKKβ, p50, p65 and TNF-α proteins (P < 0.001). There was a correlation between IKKβ, p50, p65 and TNF-α proteins (P < 0.001). ROC curve analysis showed that immunohistochemical scores for PARP1 of > 6, IKKβ of > 4, p65 of > 4, p50 of > 2, and TNF-α of > 4 had value in predicting distant metastasis (Se PARP1  = 78.35%, Sp PARP1  = 79.38%, AUC PARP1  = 0.843; Se p50  = 64.95%, Sp p50  = 70.10%, AUC p50  = 0.709; Se TNF-α  = 60.82%, Sp TNF-α  = 69.07%, AUC TNF-α  = 0.6884). Cox regression analysis showed that high expression levels of PARP1 and TNF-α were a risk factor for distant metastasis after breast cancer surgery (RR PARP1  = 4.092, 95% CI 2.475-6.766, P < 0.001; RR TNF-α  = 1.825, 95% CI 1.189-2.799, P = 0.006). Taken together, PARP1 > 6, p50 > 2, and TNF-α > 4 have a certain value in predicting breast cancer metastasis, and the predictive value is better when they are combined for diagnosis (Se combine  = 97.94%, Sp combine  = 71.13%)., (© 2024. The Author(s).)

Published
2024
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