1. Glaulactams A-C, daphniphyllum alkaloids from Daphniphyllum glaucescens
- Author
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Kuo-Wei Huang, Ju-Chien Cheng, Yang Chang Wu, Théo P. Gonçalves, Chi Chien Lin, Chih-Hua Chao, Hui-Chi Huang, and Syh Yuan Hwang
- Subjects
Stereochemistry ,Daphniphyllum glaucescens ,Drug Evaluation, Preclinical ,lcsh:Medicine ,010402 general chemistry ,Nitric Oxide ,Virus Replication ,01 natural sciences ,Antiviral Agents ,Article ,Mice ,Alkaloids ,Dogs ,Influenza A Virus, H1N1 Subtype ,Animals ,lcsh:Science ,Daphniphyllum ,Nuclear Magnetic Resonance, Biomolecular ,Multidisciplinary ,biology ,Molecular Structure ,010405 organic chemistry ,Chemistry ,Plant Extracts ,Circular Dichroism ,lcsh:R ,Daphmanidin B ,Dendritic Cells ,Circular dichroism spectra ,biology.organism_classification ,Chromatography, Ion Exchange ,0104 chemical sciences ,Mice, Inbred C57BL ,Plant Leaves ,Cytokines ,lcsh:Q ,Female - Abstract
Glaulactams A–C (1–3), which possess a novel skeleton, as well as the known compound daphmanidin B (4), were isolated from the leaves of Daphniphyllum glaucescens and separated using ion-exchange chromatography aided by NMR fingerprinting. Their structures, including their absolute configurations, were elucidated by spectroscopic analyses and time-dependent density-functional-theory-calculated electronic circular dichroism spectra; the data were subsequently analyzed to gain insight into the respective biogenetic relationships between the isolates, which exhibited anti-H1N1 and immunosuppressive activities.
- Published
- 2018