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6 results on '"Siveke, Jens"'

2. Author Correction: Hyperpolarized 13C pyruvate magnetic resonance spectroscopy for in vivo metabolic phenotyping of rat HCC

Author

Bliemsrieder, Elisabeth, Kaissis, Georgios, Grashei, Martin, Topping, Geoffrey, Altomonte, Jennifer, Hundshammer, Christian, Lohöfer, Fabian, Heid, Irina, Keim, Dominik, Gebrekidan, Selamawit, Trajkovic-Arsic, Marija, Winkelkotte, AM, Steiger, Katja, Nawroth, Roman, Siveke, Jens, Schwaiger, Markus, Makowski, Marcus, Schilling, Franz, and Braren, Rickmer

Published
2021
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3. Hyperpolarized 13C pyruvate magnetic resonance spectroscopy for in vivo metabolic phenotyping of rat HCC

Author

Bliemsrieder, Elisabeth, Kaissis, Georgios, Grashei, Martin, Topping, Geoffrey, Altomonte, Jennifer, Hundshammer, Christian, Lohöfer, Fabian, Heid, Irina, Keim, Dominik, Gebrekidan, Selamawit, Trajkovic-Arsic, Marija, Winkelkotte, AM, Steiger, Katja, Nawroth, Roman, Siveke, Jens, Schwaiger, Markus, Makowski, Marcus, Schilling, Franz, and Braren, Rickmer

Published
2021
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4. N-Myc-induced metabolic rewiring creates novel therapeutic vulnerabilities in neuroblastoma

Author

Tjaden, Britta, Baum, Katharina, Marquardt, Viktoria, Simon, Mareike, Trajkovic-Arsic, Marija, Kouril, Theresa, Siebers, Bettina, Lisec, Jan, Siveke, Jens T., Schulte, Johannes H., Benary, Uwe, Remke, Marc, Wolf, Jana, and Schramm, Alexander

Subjects
Cancer Research, Glucosamine, N-Myc Proto-Oncogene Protein, lcsh:R, Chemie, Medizin, lcsh:Medicine, Cancer metabolism, Article, Gene Expression Regulation, Neoplastic, Neuroblastoma, Glucose, RNAi, Cell Line, Tumor, Humans, lcsh:Q, lcsh:Science, Cell Proliferation
Abstract

N-Myc is a transcription factor that is aberrantly expressed in many tumor types and is often correlated with poor patient prognosis. Recently, several lines of evidence pointed to the fact that oncogenic activation of Myc family proteins is concomitant with reprogramming of tumor cells to cope with an enhanced need for metabolites during cell growth. These adaptions are driven by the ability of Myc proteins to act as transcriptional amplifiers in a tissue-of-origin specific manner. Here, we describe the effects of N-Myc overexpression on metabolic reprogramming in neuroblastoma cells. Ectopic expression of N-Myc induced a glycolytic switch that was concomitant with enhanced sensitivity towards 2-deoxyglucose, an inhibitor of glycolysis. Moreover, global metabolic profiling revealed extensive alterations in the cellular metabolome resulting from overexpression of N-Myc. Limited supply with either of the two main carbon sources, glucose or glutamine, resulted in distinct shifts in steady-state metabolite levels and significant changes in glutathione metabolism. Interestingly, interference with glutamine-glutamate conversion preferentially blocked proliferation of N-Myc overexpressing cells, when glutamine levels were reduced. Thus, our study uncovered N-Myc induction and nutrient levels as important metabolic master switches in neuroblastoma cells and identified critical nodes that restrict tumor cell proliferation. OA Förderung 2020

Published
2020

5. [68Ga]FAPI-PET/CT for radiation therapy planning in biliary tract, pancreatic ductal adeno-, and adenoidcystic carcinomas.

Author

Guberina, Nika, Kessler, Lukas, Pöttgen, Christoph, Guberina, Maja, Metzenmacher, Martin, Herrmann, Ken, Mucha, Maja, Rischpler, Christoph, Indenkämpen, Frank, Siveke, Jens T., Treckmann, Jürgen, Umutlu, Lale, Kasper, Stefan, Fendler, Wolfgang P., and Stuschke, Martin

Abstract

Biliary-tract-carcinomas (BTC), pancreatic-ductal-adenocarcinomas (PDAC) and adenoidcystic-carcinomas (AC) have in common that they are traditionally treated with large clinical-target-volumes (CTV). The aim of this study is to examine the impact of pretreatment-[68Ga]FAPI-PET/CT on target-volume-definition and posttreatment-[68Ga]FAPI-PET/CT-response-assessment for BTC-, PDAC- and AC-patients referred to radiation-therapy. All consecutive BTC-, PDAC-, and AC-patients who received pretreatment-[68Ga]FAPI-PET/CT±[18F]FDG-PET/CT were included from 01.01.2020 to 01.03.2022. MTV and SUVmax were separately generated based on [68Ga]FAPI- and [18F]FDG-PET/CT-images. A [68Ga]FAPI- and [18F]FDG-based-CTV was defined. Treatment-plans were compared. Treatment-response was reassessed by a second [68Ga]FAPI-PET/CT and [18F]FDG-PET/CT after treatment-completion. Intermodality comparison of lesion-to-background-ratios [SUVmax_lesion/SUVmean_background] for individual timepoints t1 and t2 revealed significant higher values for [68Ga]FAPI compared to [18F]FDG (t1, p = 0.008; t2, p = 0.005). Intermodality comparison of radiation-therapy-plans showed that [68Ga]FAPI-based planning resulted in D100% = 97.2% and V95% = 98.8% for the [18F]FDG-MTV. [18F]FDG-based-planning resulted in D100% = 35.9% and V95% = 78.1% for [68Ga]FAPI-MTV. [18F]FDG-based-planning resulted only in 2 patients in V95% > 95% for [68Ga]FAPI-MTV, and in 1 patient in D100% > 97% for [68Ga]FAPI-MTV. GTV-coverage in terms of V95% was 76.4% by [18F]FDG-based-planning and 99.5% by [68Ga]FAPI-based-planning. Pretreatment [68Ga]FAPI-PET/CT enhances radiation-treatment-planning in this particular group of patients. While perilesional and tumoral follow-up [18F]FDG-uptake behaved uniformly, perilesional and tumoral reaction may differ in follow-up [68Ga]FAPI-imaging. Complementary [68Ga]FAPI- and [18F]FDG-imaging enhance treatment-response-assessment. [ABSTRACT FROM AUTHOR]

Published
2022
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6. Mir34a constrains pancreatic carcinogenesis

Author

Hidalgo-Sastre, Ana, primary, Lubeseder-Martellato, Clara, additional, Engleitner, Thomas, additional, Steiger, Katja, additional, Zhong, Suyang, additional, Desztics, Judit, additional, Öllinger, Rupert, additional, Rad, Roland, additional, Schmid, Roland M., additional, Hermeking, Heiko, additional, Siveke, Jens T., additional, and von Figura, Guido, additional

Published
2020
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