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Your search keyword '"Shuqian Lin"' showing total 2 results
Start Over Author "Shuqian Lin" Journal scientific reports
2 results on '"Shuqian Lin"'

1. ILDR1 promotes influenza A virus replication through binding to PLSCR1

Author

Yueyue Liu, Shuqian Lin, Yunhui Xie, Lu Zhao, Haibo Du, Shifa Yang, Bin Yin, Guiming Li, Zengcheng Zhao, Zhongli Huang, Zhigang Xu, and Jiaqiang Wu

Subjects
Medicine, Science
Abstract

Abstract As a natural antiviral regulator, phospholipid scramblase 1 (PLSCR1) has been shown to inhibit influenza virus replication in infected cells through interacting with NP of influenza A virus (IAV). But its antiviral function as well as the underlying regulatory mechanism has not been examined in vivo. In the present work, we show that PLSCR1 expression is decreased in H1N1 SIV-infected mice, and Plscr1 −/− mice are more susceptible to H1N1 SIV infection. By performing yeast two-hybrid screening, we identified immunoglobulin-like domain-containing receptor 1 (ILDR1) as a novel PLSCR1-binding partner. ILDR1 is highly expressed in the lungs, and its expression level is increased after virus infection. Interestingly, ILDR1 could not directly interact with virus NP protein, but could combine with PLSCR1 competitively. Our data indicates that there is a previously unidentified PLSCR1-ILDR1-NP regulatory pathway playing a vital role in limiting IAV infection, which provides novel insights into IAV-host interactions.

Published
2022
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2. Ganoderma lucidum polysaccharide peptide prevents renal ischemia reperfusion injury via counteracting oxidative stress

Author

Hongkai Wang, Dandan Zhong, Shuqian Lin, Xuechen Li, Ming Huang, Ming Liu, Hong Zhou, Zhibin Lin, and Baoxue Yang

Subjects
Male, Reishi, Cell Survival, Apoptosis, Pharmacology, Mitochondrion, Biology, Kidney, medicine.disease_cause, Article, Cell Line, Mice, medicine, Animals, Polysaccharide peptide, Membrane Potential, Mitochondrial, chemistry.chemical_classification, Reactive oxygen species, Multidisciplinary, JNK Mitogen-Activated Protein Kinases, Kidney metabolism, Free Radical Scavengers, Endoplasmic Reticulum Stress, medicine.disease, Mitochondria, Rats, Mice, Inbred C57BL, Oxidative Stress, medicine.anatomical_structure, Biochemistry, chemistry, Creatinine, Reperfusion Injury, Unfolded protein response, Proteoglycans, Lipid Peroxidation, Reactive Oxygen Species, Reperfusion injury, Biomarkers, Oxidative stress
Abstract

Ganoderma lucidum polysaccharide peptide (GLPP) scavenges oxygen free radicals that are a key factor in the pathogenesis of renal ischemia reperfusion injury (RIRI). The aim of this study was to determine whether GLPP could attenuate RIRI by counteracting the oxidative stress. The mechanism involved was assessed by an in vivo mouse RIRI model and an in vitro hypoxia/reoxygenation model, and tunicamycin-stimulated NRK-52E cells were used to explore the GLPP-mediated alleviation of ER stress. Experimental results showed that renal dysfunction and morphological damage were reduced in GLPP-treated group. The imbalance of redox status was reversed and production of ROS was reduced by GLPP. RIRI-induced mitochondrial- and ER stress-dependent apoptosis were dramatically inhibited in GLPP-treated group. Intriguingly, JNK activation in the kidney with RIRI or hypoxia/reoxygenation was inhibited by GLPP. These results suggest that the protective effect of GLPP against RIRI may be due to reducing oxidative stress, alleviating the mitochondrial and ER stress-dependent apoptosis caused by excessive ROS.

Published
2015
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